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HAMAP rule MF_03105

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General rule information [?]

Accession MF_03105
Dates 14-AUG-2009 (Created)
29-SEP-2022 (Last updated, Version 8)
Name Mdm34
Scope(s) Eukaryota
Template(s) P53083 (MDM34_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03105 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MDM34
case <OC:Saccharomyces>
Protein name RecName: Full=Mitochondrial distribution and morphology protein 34;
AltName: Full=Mitochondrial outer membrane protein MMM2;
Protein name RecName: Full=Mitochondrial distribution and morphology protein 34;
end case
case <OC:Saccharomyces>
Gene name Name=MDM34; Synonyms=MMM2;
Gene name Name=MDM34;
end case

Comments [?]

FUNCTIONComponent of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. is required for the interaction of the ER-resident membrane protein @gn(MMM1) and the outer mitochondrial membrane-resident beta- barrel protein @gn(MDM10).
SUBUNITComponent of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), @gn(MDM12) and .
SUBCELLULAR LOCATIONMitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
DOMAINLacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
case <OC:Saccharomyces>
PTMUbiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin- protein ligase complex containing the F-box protein MDM30. Ubiquitination is important for mitochondrial integrity.
end case
SIMILARITYBelongs to the MDM34 family.

Keywords [?]

Gene Ontology [?]

GO:0005741; Cellular component:mitochondrial outer membrane
GO:0032865; Cellular component:ERMES complex
GO:0000002; Biological process:mitochondrial genome maintenance

Cross-references [?]

PROSITE PS51847; SMP; 1;

Features [?]

Additional information [?]

Size range 343-1097 amino acids
Related rules None
Fusion Nter: None Cter: None

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