HAMAP rule MF_03105
General rule information
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Accession | MF_03105 |
Dates | 14-AUG-2009 (Created) 29-SEP-2022 (Last updated, Version 8) |
Name | Mdm34 |
Scope | Eukaryota; Fungi |
Template | P53083 (MDM34_YEAST) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Saccharomyces>
Protein name |
|
else
Protein name |
|
end case
case <OC:Saccharomyces>
Gene name |
|
else
Gene name |
|
end case
Comments
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Function | Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. |
Subunit | Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), @gn(MDM12) and |
Subcellular location | Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids. |
Domain | Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin. |
case <OC:Saccharomyces>
Ptm | Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex containing the F-box protein MDM30. Ubiquitination is important for mitochondrial integrity. |
end case
Similarity | Belongs to the MDM34 family. |
Keywords
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case <OC:Saccharomyces>
end case
Gene Ontology
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GO:0005741; Cellular component: mitochondrial outer membrane.
GO:0032865; Cellular component: ERMES complex.
GO:0000002; Biological process: mitochondrial genome maintenance.
GO:0032865; Cellular component: ERMES complex.
GO:0000002; Biological process: mitochondrial genome maintenance.
Cross-references
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Additional information
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Size range | 343-1097 amino acids |
Related rules | None |
Fusion | None |