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HAMAP rule MF_03105

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General rule information [?]

Accession MF_03105
Dates 14-AUG-2009 (Created)
29-SEP-2022 (Last updated, Version 8)
Name Mdm34
Scope
Eukaryota; Fungi
Template P53083 (MDM34_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MDM34
case <OC:Saccharomyces>
Protein name
RecName: Full=Mitochondrial distribution and morphology protein 34;
AltName: Full=Mitochondrial outer membrane protein MMM2;
else
Protein name
RecName: Full=Mitochondrial distribution and morphology protein 34;
end case
case <OC:Saccharomyces>
Gene name
MDM34, MMM2
else
Gene name
MDM34
end case

Comments [?]

Function Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. is required for the interaction of the ER-resident membrane protein @gn(MMM1) and the outer mitochondrial membrane-resident beta-barrel protein @gn(MDM10).
Subunit Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), @gn(MDM12) and .
Subcellular location Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
case <OC:Saccharomyces>
Ptm Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex containing the F-box protein MDM30. Ubiquitination is important for mitochondrial integrity.
end case
Similarity Belongs to the MDM34 family.

Keywords [?]

Membrane
Mitochondrion
Mitochondrion outer membrane
Transmembrane
Transmembrane beta strand
case <OC:Saccharomyces>
Ubl conjugation
end case

Gene Ontology [?]

GO:0005741; Cellular component: mitochondrial outer membrane.
GO:0032865; Cellular component: ERMES complex.
GO:0000002; Biological process: mitochondrial genome maintenance.

Cross-references [?]

PROSITE PS51847; SMP; 1; trigger=PRU01194;

Additional information [?]

Size range 343-1097 amino acids
Related rules None
Fusion None


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