||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. is required for the interaction of the ER-resident membrane protein @gn(MMM1) and the outer mitochondrial membrane-resident beta-barrel protein @gn(MDM10).
||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), @gn(MDM12) and .
||Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
||Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.