HAMAP rule MF_03108
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03108 |
| Accession | MF_03108 |
| Dates | 05-OCT-2012 (Created)
31-OCT-2024 (Last updated, Version 16) |
| Name | Catal-peroxid_euk |
| Scope(s) |
Eukaryota Fungi |
| Template(s) | A4QUT2; A4R5S9; Q8X182; Q96VT4; [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01961 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KATG |
| Protein name | RecName: Full=Catalase-peroxidase; Short=CP; EC=1.11.1.21; AltName: Full=Peroxidase/catalase; |
| Gene name | Name=katG; |
Comments
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| case <Feature:Signal==1> | |
| FUNCTION | Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection. |
| else | |
| FUNCTION | Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=H2O2 + AH2 = A + 2 H2O; Xref=Rhea:RHEA:30275, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:17499; EC=1.11.1.21; |
| CATALYTIC ACTIVITY | Reaction=2 H2O2 = O2 + 2 H2O; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.21; |
| COFACTOR | Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.; |
| case <Feature:Signal==1> | |
| SUBUNIT | Homodimer; disulfide-linked. |
| SUBCELLULAR LOCATION | Secreted. |
| else | |
| SUBUNIT | Homodimer or homotetramer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| PTM | Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme. |
| SIMILARITY | Belongs to the peroxidase family. Peroxidase/catalase subfamily. |
Keywords
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| Heme | |
| Hydrogen peroxide | |
| Iron | |
| Metal-binding | |
| Oxidoreductase | |
| Peroxidase | |
| case <Feature:Signal==1> | |
| Disulfide bond | |
| Secreted | |
| else | |
| Cytoplasm | |
| end case | |
Gene Ontology
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| GO:0004096; Molecular function:catalase activity |
| GO:0004601; Molecular function:peroxidase activity |
Cross-references
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| PROSITE | PS00435; PEROXIDASE_1; 1; |
| PROSITE | PS00436; PEROXIDASE_2; 1; |
| PROSITE | PS50873; PEROXIDASE_4; 1; |
| Pfam | PF00141; peroxidase; 2; |
| PRINTS | PR00460; BPEROXIDASE; 1; |
| PRINTS | PR00458; PEROXIDASE; 1; |
| NCBIfam | TIGR00198; cat_per_HPI; 1; |
| General | Signal; -; 0-1; |
Features
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| From: KATG2_PYRO7 (A4QUT2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 141 | 141 | /note="Proton acceptor" | H | ||||||||
| BINDING | 314 | 314 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
H | ||||||||
| SITE | 137 | 137 | /note="Transition state stabilizer" | R | ||||||||
| CROSSLNK | 140 | 273 | /note="Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with #{Met-299})" | W-x*-Y | ||||||||
| CROSSLNK | 273 | 299 | /note="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with #{Trp-140})" | Y-x*-M | ||||||||
| case <Feature:Signal==1> | ||||||||||||
| DISULFID | 55 | 55 | /note="Interchain (with #{Cys-74})" | C | ||||||||
| DISULFID | 74 | 74 | /note="Interchain (with #{Cys-55})" | C | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 730-786 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |