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Annotation rule MF_03108
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General rule information [?]

Accession MF_03108
Dates 14-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 8)
Name Catal-peroxid_euk
Scope
Eukaryota; Fungi
Templates A4QUT2 (KATG2_MAGO7); A4R5S9 (KATG1_MAGO7); Q8X182 (KATG_NEUCR); Q96VT4 (KATG_EMENI): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KATG
Protein name
RecName: Full=Catalase-peroxidase;
Short=CP;
EC 1.11.1.21;
AltName: Full=Peroxidase/catalase;
Gene name
katG

Comments [?]

case <Feature:Signal==1>
Function Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection.
else
Function Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
end case
Catalytic activity RHEA:30275: AH2 + H2O2 = A + 2 H2O
EC 1.11.1.21
RHEA:20309: 2 H2O2 = 2 H2O + O2
EC 1.11.1.21
Cofactor heme b
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.
case <Feature:Signal==1>
Subunit Homodimer; disulfide-linked.
Subcellular location Secreted.
else
Subunit Homodimer or homotetramer.
Subcellular location Cytoplasm.
end case
Ptm Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
Similarity Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Keywords [?]

case <Feature:Signal==1>
else
end case

Gene Ontology [?]

GO:0004096; Molecular function: catalase activity.
GO:0004601; Molecular function: peroxidase activity.

Cross-references [?]

PROSITE PS00435; PEROXIDASE_1; 1;
PS00436; PEROXIDASE_2; 1;
PS50873; PEROXIDASE_4; 1;
Pfam PF00141; peroxidase; 2;
PRINTS PR00460; BPEROXIDASE; 1;
PR00458; PEROXIDASE; 1;
TIGRFAMs TIGR00198; cat_per_HPI; 1;

Computed features [?]

General Signal; -; 0-1; trigger=yes;

Features [?]

From: KATG2_MAGO7 (A4QUT2)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     141     141       Proton acceptor     H  
METAL     314     314       Iron (heme axial ligand)     H  
SITE     137     137       Transition state stabilizer     R  
CROSSLNK     140     273       Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with #{Met-299})     W-x*-Y  
CROSSLNK     273     299       Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with #{Trp-140})     Y-x*-M  
case <Feature:Signal==1>
DISULFID     55     55       Interchain (with #{Cys-74})     C  
DISULFID     74     74       Interchain (with #{Cys-55})     C  
end case

Additional information [?]

Size range 730-786 amino acids
Related rules None
Fusion None