HAMAP rule MF_03109
General rule information
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| Accession | MF_03109 |
| Dates | 21-AUG-2009 (Created)
19-NOV-2022 (Last updated, Version 9) |
| Name | Sey1 |
| Scope(s) |
Eukaryota |
| Template(s) | Q99287 (SEY1_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03109 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Viridiplantae> | |
| Identifier | RHD3 |
| else | |
| Identifier | SEY1 |
| end case | |
| case <OC:Saccharomyces> | |
| Protein name | RecName: Full=Protein SEY1; EC=3.6.5.-; AltName: Full=Synthetic enhancer of YOP1 protein; |
| else case <OC:Fungi> and not <OC:Saccharomyces> | |
| Protein name | RecName: Full=Protein EC=3.6.5.-; |
| else case <OC:Viridiplantae> | |
| Protein name | RecName: Full=Protein ROOT HAIR DEFECTIVE 3 homolog; EC=3.6.5.-; AltName: Full=Protein SEY1 homolog; |
| else | |
| Protein name | RecName: Full=Protein SEY1 homolog; EC=3.6.5.-; |
| end case | |
| case <OC:Fungi> | |
| Gene name | Name=SEY1; |
| end case | |
Comments
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| case <OC:Saccharomyces> | |
| FUNCTION | Cooperates with the reticulon proteins RTN1 and RTN2 and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization. |
| else case <OC:Fungi> | |
| FUNCTION | Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization. |
| else | |
| FUNCTION | Probable GTP-binding protein that may be involved in cell development. |
| end case | |
| case <OC:Saccharomyces> | |
| SUBUNIT | Interacts with RTN1 and YOP1; GTP binding is not required for these interactions. |
| end case | |
| case <OC:Fungi> | |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules. |
| else | |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily. |
Keywords
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| Endoplasmic reticulum |
| GTP-binding |
| Hydrolase |
| Membrane |
| Nucleotide-binding |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0005789; Cellular component:endoplasmic reticulum membrane | |
| case <OCellular component:Fungi> | |
| GO:0007029; Biological process:endoplasmic reticulum organization | |
| end case | |
| GO:0003924; Molecular function:GTPase activity | |
| GO:0005525; Molecular function:GTP binding | |
Cross-references
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| Pfam | PF05879; RHD3; 1; |
| PROSITE | PS51715; G_GB1_RHD3; 1; |
| General | Coiled_coil; -; 0-unlimited; |
| General | Transmembrane; -; 0-3; |
Features
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| From: SEY1_YEAST (Q99287) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 681 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 682 | 702 | /note="Helical" | |||||||||
| TOPO_DOM | 703 | 705 | /note="Lumenal" | |||||||||
| TRANSMEM | 706 | 726 | /note="Helical" | |||||||||
| TOPO_DOM | 727 | Cter | /note="Cytoplasmic" | |||||||||
| BINDING | 44 | 51 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
G-x(4)-G-K-S | ||||||||
Additional information
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| Size range | 732-1035 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |