HAMAP rule MF_03111

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_03111
Accession	MF_03111
Dates	26-OCT-2012 (Created) 01-APR-2025 (Last updated, Version 8)
Name	Coq4
Scope(s)	Eukaryota
Template(s)	O13525; Q9Y3A0; [ Recover all ]
Triggered by	HAMAP; MF_03111 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	COQ4
case <OC:Fungi> or <OC:Caenorhabditis>
Protein name	RecName: Full=Ubiquinone biosynthesis protein , mitochondrial; AltName: Full=Coenzyme Q biosynthesis protein 4; AltName: Full=4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; EC=4.1.1.130;
else
Protein name	RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; AltName: Full=Coenzyme Q biosynthesis protein 4 homolog; AltName: Full=4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; EC=4.1.1.130;
end case
case <OC:Vertebrata> or <OC:Fungi> or <OC:Dictyostelium>
Gene name	Name=COQ4;
else case <OC:Caenorhabditis>
Gene name	Name=coq-4;
end case

Comments [?]

case <OC:Mammalia> or <OC:Schizosaccharomyces>
FUNCTION	Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3- methoxy-5-(all-trans-decaprenyl)benzoic acid into 2-methoxy-6-(all- trans-decaprenyl)phenol during ubiquinone biosynthesis.
CATALYTIC ACTIVITY	Reaction=4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoate + H(+) = 2-methoxy-6-(all-trans-decaprenyl)phenol + CO2; Xref=Rhea:RHEA:81275, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:50774, ChEBI:CHEBI:62796; EC=4.1.1.130;
else case <OC:Saccharomyces>
FUNCTION	Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3- methoxy-5-(all-trans-hexaprenyl)benzoic acid into 2-methoxy-6-(all- trans-hexaprenyl)phenol during ubiquinone biosynthesis.
CATALYTIC ACTIVITY	Reaction=4-hydroxy-3-methoxy-5-(all-trans-hexaprenyl)benzoate + H(+) = 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2; Xref=Rhea:RHEA:44768, ChEBI:CHEBI:1109, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57916; EC=4.1.1.130;
else
FUNCTION	Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3- methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all- trans-polyprenyl)phenol during ubiquinone biosynthesis.
CATALYTIC ACTIVITY	Reaction=a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2; Xref=Rhea:RHEA:81179, Rhea:RHEA-COMP:9551, Rhea:RHEA-COMP:10931, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:62731, ChEBI:CHEBI:84443; EC=4.1.1.130;
end case
COFACTOR	Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
PATHWAY	Cofactor biosynthesis; ubiquinone biosynthesis.
case <OC:Saccharomyces>
SUBUNIT	Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with COQ3.
else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces>
SUBUNIT	Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9).
else
SUBUNIT	Component of a multi-subunit COQ enzyme complex.
end case
SUBCELLULAR LOCATION	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
case not <AnyFeature:TransitM>
MISCELLANEOUS	This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITY	Belongs to the COQ4 family.