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HAMAP rule MF_03119

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General rule information [?]

Accession MF_03119
Dates 22-OCT-2010 (Created)
1-JUN-2023 (Last updated, Version 8)
Name Salvage_MtnA_euk
Scope(s) Eukaryota
Template(s) Q9BV20 (MTNA_HUMAN); Q06489 (MTNA_YEAST); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_01678 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTNA
Protein name RecName: Full=Methylthioribose-1-phosphate isomerase;
                 Short=MTR-1-P isomerase;
AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
AltName: Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein;
case <OC:Vertebrata> or <OC:Fungi>
Gene name Name=MRI1;
end case

Comments [?]

FUNCTIONCatalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
CATALYTIC ACTIVITY Reaction=S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio- D-ribulose 1-phosphate; Xref=Rhea:RHEA:19989, ChEBI:CHEBI:58533, ChEBI:CHEBI:58548; EC=;
PATHWAYAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.
case <OC:Saccharomyces>
end case
SIMILARITYBelongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0046523; Molecular function:S-methyl-5-thioribose-1-phosphate isomerase activity
GO:0019284; Biological process:L-methionine salvage from S-adenosylmethionine
GO:0005737; Cellular component:cytoplasm
GO:0005634; Cellular component:nucleus

Cross-references [?]

Pfam PF01008; IF-2B; 1;
NCBIfam TIGR00524; EIF-2B_rel; 1;
NCBIfam TIGR00512; Salvage_mtnA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 248 248 /note="Proton donor" D
SITE 168 168 /note="Transition state stabilizer" C

Additional information [?]

Size range 350-445 amino acids
Related rules None
Fusion Nter: None Cter: None

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