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HAMAP rule MF_03119
General rule information
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| Accession | MF_03119 |
| Dates | 22-OCT-2010 (Created)
24-MAY-2024 (Last updated, Version 9) |
| Name | Salvage_MtnA_euk |
| Scope(s) |
Eukaryota |
| Template(s) | Q9BV20 (MTNA_HUMAN); Q06489 (MTNA_YEAST); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01678 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MTNA |
| Protein name | RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi; Short=MTR-1-P isomerase; EC=5.3.1.23; AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase; AltName: Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein; |
| case <OC:Vertebrata> or <OC:Fungi> | |
| Gene name | Name=MRI1; |
| end case | |
Comments
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| FUNCTION | Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). |
| CATALYTIC ACTIVITY | Reaction=S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio- D-ribulose 1-phosphate; Xref=Rhea:RHEA:19989, ChEBI:CHEBI:58533, ChEBI:CHEBI:58548; EC=5.3.1.23; |
| PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. |
| case <OC:Saccharomyces> | |
| SUBUNIT | Homodimer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. Nucleus. |
| SIMILARITY | Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. |
Keywords
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Gene Ontology
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| GO:0046523; Molecular function:S-methyl-5-thioribose-1-phosphate isomerase activity |
| GO:0019509; Biological process:L-methionine salvage from methylthioadenosine |
| GO:0005737; Cellular component:cytoplasm |
| GO:0005634; Cellular component:nucleus |
Cross-references
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Features
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| From: MTNA_HUMAN (Q9BV20) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 248 | 248 | /note="Proton donor" | D | ||||||||
| SITE | 168 | 168 | /note="Transition state stabilizer" | C | ||||||||
Additional information
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| Size range | 350-445 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |