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Annotation rule MF_03119
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General rule information [?]

Accession MF_03119
Dates 22-OCT-2010 (Created)
6-MAY-2020 (Last updated, Version 7)
Name Salvage_MtnA_euk
Scope
Eukaryota
Templates Q9BV20 (MTNA_HUMAN); Q06489 (MTNA_YEAST): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTNA
Protein name
RecName: Full=Methylthioribose-1-phosphate isomerase;
Short=M1Pi;
Short=MTR-1-P isomerase;
EC 5.3.1.23;
AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
AltName: Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein;
case <OC:Vertebrata> or <OC:Fungi>
Gene name
MRI1
end case

Comments [?]

Function Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Catalytic activity RHEA:19989: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
EC 5.3.1.23
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.
case <OC:Saccharomyces>
Subunit Homodimer.
end case
Subcellular location Cytoplasm. Nucleus.
Similarity Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0046523; Molecular function: S-methyl-5-thioribose-1-phosphate isomerase activity.
GO:0019284; Biological process: L-methionine salvage from S-adenosylmethionine.
GO:0005737; Cellular component: cytoplasm.
GO:0005634; Cellular component: nucleus.

Cross-references [?]

Pfam PF01008; IF-2B; 1;
TIGRFAMs TIGR00524; EIF-2B_rel; 1;
TIGR00512; Salvage_mtnA; 1;

Features [?]

From: MTNA_HUMAN (Q9BV20)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     248     248       Proton donor     D  
SITE     168     168       Transition state stabilizer     C  

Additional information [?]

Size range 350-445 amino acids
Related rules None
Fusion None