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HAMAP rule MF_03132

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General rule information [?]

Accession MF_03132
Dates 22-OCT-2010 (Created)
1-JUN-2023 (Last updated, Version 7)
Name eIF-6_euk
Scope(s) Eukaryota
Template(s) P56537 (IF6_HUMAN); Q12522 (IF6_YEAST); O55135 (IF6_MOUSE); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00032 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier IF6
Protein name RecName: Full=Eukaryotic translation initiation factor 6;
                 Short=eIF-6;
case <OC:Fungi>
Gene name Name=TIF6;
else case <OC:Mammalia>
Gene name Name=EIF6; Synonyms=ITGB4BP;
else case <OC:Caenorhabditis>
Gene name Name=eif-6;
else case <OC:Drosophilidae>
Gene name Name=eIF6;
else
Gene name Name=EIF6;
end case

Comments [?]

case <OC:Mammalia>
FUNCTIONBinds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS- dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
else case <OC:Caenorhabditis>
FUNCTIONBinds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing.
else case <OC:Saccharomyces>
FUNCTIONBinds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing.
else case <OC:Fungi> and not <OC:Saccharomyces>
FUNCTIONBinds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.
else
FUNCTIONBinds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
end case
case <OC:Mammalia>
SUBUNITMonomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
else
SUBUNITMonomer. Associates with the 60S ribosomal subunit.
end case
SUBCELLULAR LOCATIONCytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
case (<OC:Mammalia> or <OC:Fungi>) and <FTGroup:1>
PTMPhosphorylation at #{Ser-174} and #{Ser-175} promotes nuclear export.
end case
SIMILARITYBelongs to the eIF-6 family.

Keywords [?]

Cytoplasm
Initiation factor
Nucleus
Protein biosynthesis
Ribosome biogenesis
case (<OC:Mammalia> or <OC:Fungi>) and <FTGroup:1> or <FTTag:phospho>
Phosphoprotein
end case

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0005730; Cellular component:nucleolus
GO:0043023; Molecular function:ribosomal large subunit binding
GO:0003743; Molecular function:translation initiation factor activity
GO:0042256; Biological process:cytosolic ribosome assembly
GO:0042273; Biological process:ribosomal large subunit biogenesis
GO:0006413; Biological process:translational initiation
case <OCellular component:Mammalia> or <OC:Fungi>
GO:0000054; Biological process:ribosomal subunit export from nucleus
end case

Cross-references [?]

Pfam PF01912; eIF-6; 1;
NCBIfam TIGR00323; EIF-6; 1;
PIRSF PIRSF006413; IF-6; 1;

Features [?]

From: IF6_YEAST (Q12522)
Key From To Description Tag Condition FTGroup
case <OC:Mammalia> or <OC:Fungi>
MOD_RES 174 174 /note="Phosphoserine; by CK1" S 1
MOD_RES 175 175 /note="Phosphoserine; by CK1" S 1
end case
From: IF6_HUMAN (P56537)
Key From To Description Tag Condition FTGroup
case <OC:Mammalia>
MOD_RES 165 165 /note="Phosphothreonine" phospho T
MOD_RES 166 166 /note="Phosphoserine" phospho S
end case

Additional information [?]

Size range 226-284 amino acids
Related rules None
Fusion Nter: None Cter: None



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