 |
|
| Annotation rule MF_03132 |
General rule information
[?]
| Accession | MF_03132 |
| Dates | 22-OCT-2010 (Created) 20-NOV-2019 (Last updated, Version 5) |
| Name | eIF-6_euk |
| Scope | Eukaryota |
| Templates | P56537 (IF6_HUMAN); Q12522 (IF6_YEAST); O55135 (IF6_MOUSE): [Recover all] |
case <OC:Eukaryota>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
| Protein name |
|
||||||||
case <OC:Fungi>
| Gene name |
|
else case <OC:Mammalia>
| Gene name |
|
else case <OC:Caenorhabditis>
| Gene name |
|
else case <OC:Drosophilidae>
| Gene name |
|
else
| Gene name |
|
end case
Comments
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case <OC:Mammalia>
| Function | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth. |
else case <OC:Caenorhabditis>
| Function | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing. |
else case <OC:Saccharomyces>
| Function | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing. |
else case <OC:Fungi> and not <OC:Saccharomyces>
| Function | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. |
else
| Function | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. |
end case
case <OC:Mammalia>
| Subunit | Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC). |
else
| Subunit | Monomer. Associates with the 60S ribosomal subunit. |
end case
| Subcellular location | Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus. |
case (<OC:Mammalia> or <OC:Fungi>) and <FTGroup:1>
| Ptm | Phosphorylation at #{Ser-174} and #{Ser-175} promotes nuclear export. |
end case
| Similarity | Belongs to the eIF-6 family. |
Keywords
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case (<OC:Mammalia> or <OC:Fungi>) and <FTGroup:1> or <FTTag:phospho>
end case
Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0005730; Cellular component: nucleolus.
GO:0043023; Molecular function: ribosomal large subunit binding.
GO:0003743; Molecular function: translation initiation factor activity.
GO:0042256; Biological process: mature ribosome assembly.
GO:0042273; Biological process: ribosomal large subunit biogenesis.
GO:0006413; Biological process: translational initiation.
GO:0005730; Cellular component: nucleolus.
GO:0043023; Molecular function: ribosomal large subunit binding.
GO:0003743; Molecular function: translation initiation factor activity.
GO:0042256; Biological process: mature ribosome assembly.
GO:0042273; Biological process: ribosomal large subunit biogenesis.
GO:0006413; Biological process: translational initiation.
case <OC:Mammalia> or <OC:Fungi>
GO:0000054; Biological process: ribosomal subunit export from nucleus.
end case
Cross-references
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| Pfam | PF01912; eIF-6; 1; |
| TIGRFAMs | TIGR00323; EIF-6; 1; |
| PIRSF | PIRSF006413; IF-6; 1; |
Features
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case <OC:Mammalia> or <OC:Fungi>
| From: IF6_YEAST (Q12522) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES (Optional) | 174 | 174 | Phosphoserine; by CK1 | S | 1 | |||||||
| MOD_RES (Optional) | 175 | 175 | Phosphoserine; by CK1 | S | 1 | |||||||
end case
case <OC:Mammalia>
| From: IF6_HUMAN (P56537) | ||||||||||||
| MOD_RES | 165 | 165 | Phosphothreonine | phospho | T | |||||||
| MOD_RES | 166 | 166 | Phosphoserine | phospho | S | |||||||
end case
Additional information
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| Size range | 226-284 amino acids |
| Related rules | None |
| Fusion | None |