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Annotation rule MF_03132
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General rule information [?]

Accession MF_03132
Dates 22-OCT-2010 (Created)
20-NOV-2019 (Last updated, Version 5)
Name eIF-6_euk
Scope
Eukaryota
Templates P56537 (IF6_HUMAN); Q12522 (IF6_YEAST); O55135 (IF6_MOUSE): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
IF6
Protein name
RecName: Full=Eukaryotic translation initiation factor 6;
Short=eIF-6;
case <OC:Fungi>
Gene name
TIF6
else case <OC:Mammalia>
Gene name
EIF6, ITGB4BP
else case <OC:Caenorhabditis>
Gene name
eif-6
else case <OC:Drosophilidae>
Gene name
eIF6
else
Gene name
EIF6
end case

Comments [?]

case <OC:Mammalia>
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
else case <OC:Caenorhabditis>
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing.
else case <OC:Saccharomyces>
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing.
else case <OC:Fungi> and not <OC:Saccharomyces>
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.
else
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
end case
case <OC:Mammalia>
Subunit Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
else
Subunit Monomer. Associates with the 60S ribosomal subunit.
end case
Subcellular location Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
case (<OC:Mammalia> or <OC:Fungi>) and <FTGroup:1>
Ptm Phosphorylation at #{Ser-174} and #{Ser-175} promotes nuclear export.
end case
Similarity Belongs to the eIF-6 family.

Keywords [?]

case (<OC:Mammalia> or <OC:Fungi>) and <FTGroup:1> or <FTTag:phospho>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0005730; Cellular component: nucleolus.
GO:0043023; Molecular function: ribosomal large subunit binding.
GO:0003743; Molecular function: translation initiation factor activity.
GO:0042256; Biological process: mature ribosome assembly.
GO:0042273; Biological process: ribosomal large subunit biogenesis.
GO:0006413; Biological process: translational initiation.
case <OC:Mammalia> or <OC:Fungi>
GO:0000054; Biological process: ribosomal subunit export from nucleus.
end case

Cross-references [?]

Pfam PF01912; eIF-6; 1;
TIGRFAMs TIGR00323; EIF-6; 1;
PIRSF PIRSF006413; IF-6; 1;

Features [?]

case <OC:Mammalia> or <OC:Fungi>
From: IF6_YEAST (Q12522)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES (Optional)     174     174       Phosphoserine; by CK1     S   1
MOD_RES (Optional)     175     175       Phosphoserine; by CK1     S   1
end case
case <OC:Mammalia>
From: IF6_HUMAN (P56537)
MOD_RES     165     165       Phosphothreonine   phospho   T  
MOD_RES     166     166       Phosphoserine   phospho   S  
end case

Additional information [?]

Size range 226-284 amino acids
Related rules None
Fusion None