HAMAP rule MF_03138
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03138 |
| Accession | MF_03138 |
| Dates | 21-AUG-2012 (Created)
03-SEP-2024 (Last updated, Version 13) |
| Name | GUFP |
| Scope(s) |
Eukaryota Viridiplantae Plastid |
| Template(s) | Q9FNM5; [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota> or <OG:Plastid>
HAMAP; MF_03138 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GUFP |
| case <OG:Organellar chromatophore> | |
| Protein name | RecName: Full=Translation factor GUF1 homolog, organellar chromatophore; EC=3.6.5.n1; AltName: Full=Elongation factor 4 homolog; Short=EF-4; AltName: Full=GTPase GUF1 homolog; AltName: Full=Ribosomal back-translocase; |
| else | |
| Protein name | RecName: Full=Translation factor GUF1 homolog, chloroplastic; EC=3.6.5.n1; AltName: Full=Elongation factor 4 homolog; Short=EF-4; AltName: Full=GTPase GUF1 homolog; AltName: Full=Ribosomal back-translocase; |
| end case | |
| case <OG:Organellar chromatophore> | |
| Gene name | Name=lepA; |
| end case | |
Comments
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| case <OG:Organellar chromatophore> | |
| FUNCTION | Promotes protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. |
| else | |
| FUNCTION | Promotes chloroplast protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=GTP + H2O = GDP + phosphate + H(+); Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.n1; |
| case <OG:Organellar chromatophore> | |
| SUBCELLULAR LOCATION | Plastid, organellar chromatophore. |
| else | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| case not <OG:Organellar chromatophore> and not <AnyFeature:TransitC> | |
| MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
| end case | |
| SIMILARITY | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily. |
Keywords
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| case <OG:Organellar chromatophore> | |
| Organellar chromatophore | |
| else | |
| Chloroplast | |
| end case | |
| Plastid | |
| GTP-binding | |
| Hydrolase | |
| Nucleotide-binding | |
| Protein biosynthesis | |
Gene Ontology
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| case <OG:Organellar chromatophore> | |
| GO:0070111; Cellular component:organellar chromatophore | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
| GO:0005525; Molecular function:GTP binding | |
| GO:0003924; Molecular function:GTPase activity | |
| GO:0045727; Biological process:positive regulation of translation | |
Cross-references
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| Pfam | PF00679; EFG_C; 1; |
| Pfam | PF00009; GTP_EFTU; 1; |
| Pfam | PF03144; GTP_EFTU_D2; 1; |
| Pfam | PF06421; LepA_C; 1; |
| PRINTS | PR00315; ELONGATNFCT; 1; |
| NCBIfam | TIGR01393; LepA; 1; |
| NCBIfam | TIGR00231; Small_GTP; 1; |
| PROSITE | PS00301; G_TR_1; 1; |
| PROSITE | PS51722; G_TR_2; 1; |
| General | TransitC; -; 0-1; |
Features
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| From: GUFP_ARATH (Q9FNM5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 93 | 100 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[AS]-H-[IV]-D-[HS]-G-K-[ST] | ||||||||
| BINDING | 158 | 162 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D-T-[CP]-G-H | ||||||||
| BINDING | 212 | 215 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[NT]-K-[IMV]-D | ||||||||
Additional information
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| Size range | 602-735 amino acids |
| Related rules |
MF_03138 |
| Fusion | Nter: None Cter: None |