HAMAP rule MF_03142
General rule information
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| Accession | MF_03142 |
| Dates | 16-FEB-2011 (Created)
1-JUN-2023 (Last updated, Version 10) |
| Name | Formald_GSH_euk |
| Scope(s) |
Eukaryota Pezizomycotina |
| Template(s) | C8VDQ3 (GFA_EMENI); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_00723 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GFA |
| Protein name | RecName: Full=Putative glutathione-dependent formaldehyde-activating enzyme; EC=4.4.1.22; AltName: Full=S-(hydroxymethyl)glutathione synthase; |
Comments
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| FUNCTION | Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione. |
| CATALYTIC ACTIVITY | Reaction=S-(hydroxymethyl)glutathione = formaldehyde + glutathione; Xref=Rhea:RHEA:22488, ChEBI:CHEBI:16842, ChEBI:CHEBI:57925, ChEBI:CHEBI:58758; EC=4.4.1.22; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; |
| end case | |
| PATHWAY | One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3. |
| SIMILARITY | Belongs to the Gfa family. |
Keywords
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Gene Ontology
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| GO:0051907; Molecular function:S-(hydroxymethyl)glutathione synthase activity | |
| GO:0046294; Biological process:formaldehyde catabolic process | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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| Pfam | PF04828; GFA; 1; |
| NCBIfam | TIGR02820; Formald_GSH; 1; |
| PIRSF | PIRSF033318; Formald_GSH; 1; |
| PROSITE | PS51891; CENP_V_GFA; 1; |
Features
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| From: GFA_EMENI (C8VDQ3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 29 | 29 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="structural" |
C | 1 | |||||||
| BINDING | 31 | 31 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="structural" |
C | 1 | |||||||
| BINDING | 50 | 50 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic" |
C | 1 | |||||||
| BINDING | 52 | 52 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic" |
C | 1 | |||||||
| BINDING | 55 | 55 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic" |
C | 1 | |||||||
| BINDING | 97 | 97 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="structural" |
C | 1 | |||||||
| BINDING | 100 | 100 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="structural" |
C | 1 | |||||||
Additional information
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| Size range | 186-197 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |