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Annotation rule MF_03142
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General rule information [?]

Accession MF_03142
Dates 16-FEB-2011 (Created)
20-NOV-2019 (Last updated, Version 7)
Name Formald_GSH_euk
Scope
Eukaryota; Pezizomycotina
Template C8VDQ3 (GFA_EMENI)
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GFA
Protein name
RecName: Full=Putative glutathione-dependent formaldehyde-activating enzyme;
EC 4.4.1.22;
AltName: Full=S-(hydroxymethyl)glutathione synthase;

Comments [?]

Function Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.
Catalytic activity RHEA:22488: S-(hydroxymethyl)glutathione = formaldehyde + glutathione
EC 4.4.1.22
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit.
end case
Pathway One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.
Similarity Belongs to the Gfa family.

Keywords [?]


Gene Ontology [?]

GO:0051907; Molecular function: S-(hydroxymethyl)glutathione synthase activity.
GO:0046294; Biological process: formaldehyde catabolic process.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF04828; GFA; 1;
TIGRFAMs TIGR02820; Formald_GSH; 1;
PIRSF PIRSF033318; Formald_GSH; 1;
PROSITE PS51891; CENP_V_GFA; 1; trigger=PRU01239;

Features [?]

From: GFA_EMENI (C8VDQ3)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     29     29       Zinc 1; structural     C   1
METAL     31     31       Zinc 1; structural     C   1
METAL     50     50       Zinc 2; catalytic     C   1
METAL     52     52       Zinc 2; catalytic     C   1
METAL     55     55       Zinc 2; catalytic     C   1
METAL     97     97       Zinc 1; structural     C   1
METAL     100     100       Zinc 1; structural     C   1

Additional information [?]

Size range 186-197 amino acids
Related rules None
Fusion None