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Annotation rule MF_03152 |
General rule information
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Accession |
MF_03152 |
Dates |
17-OCT-2011 (Created) 20-NOV-2019 (Last updated, Version 7) |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Saccharomyces>
Protein name |
RecName:
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Full=tRNA (guanine(37)-N1)-methyltransferase;
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EC 2.1.1.228;
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AltName:
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Full=M1G-methyltransferase;
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AltName:
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Full=tRNA [GM37] methyltransferase;
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AltName:
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Full=tRNA methyltransferase 5;
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Flags:
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Precursor;
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else case <OC:Fungi>
Protein name |
RecName:
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Full=tRNA (guanine(37)-N1)-methyltransferase;
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EC 2.1.1.228;
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AltName:
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Full=M1G-methyltransferase;
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AltName:
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Full=tRNA [GM37] methyltransferase;
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AltName:
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Full=tRNA methyltransferase 5;
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else
Protein name |
RecName:
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Full=tRNA (guanine(37)-N1)-methyltransferase;
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EC 2.1.1.228;
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AltName:
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Full=M1G-methyltransferase;
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AltName:
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Full=tRNA [GM37] methyltransferase;
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AltName:
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Full=tRNA methyltransferase 5 homolog;
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end case
case <OC:Vertebrata>
else case <OC:Fungi>
end case
case <OC:Saccharomyces>
Function |
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Postspliced cytoplasmic tRNAs are imported into the nucleus, where this first step seems to take place, after which they are reexported to the cytoplasm, where the yW sythesis is completed by cytoplasmic enzymes. |
else
Function |
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. |
end case
Catalytic activity |
RHEA:36899: guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine
EC 2.1.1.228
|
Subunit |
Monomer. |
Subcellular location |
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus. |
Similarity |
Belongs to the TRM5 / TYW2 family. |
case <OC:Saccharomyces>
end case
GO:0005759; Cellular component: mitochondrial matrix.
GO:0005634; Cellular component: nucleus.
GO:0005737; Cellular component: cytoplasm.
GO:0030488; Biological process: tRNA methylation.
GO:0009019; Molecular function: tRNA (guanine-N1-)-methyltransferase activity.
case not <OC:Saccharomyces>
General |
TransitM; -; 0-1; trigger=yes; |
end case
case <OC:Saccharomyces>
From: TRM5_YEAST (P38793) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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TRANSIT
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Nter
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44
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Mitochondrion
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CHAIN
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45
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Cter
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end case
REGION
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307
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308
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S-adenosyl-L-methionine binding
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[DE]-[ILM]
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REGION
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335
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336
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S-adenosyl-L-methionine binding
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[DE]-[AGNSV]
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BINDING
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268
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268
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S-adenosyl-L-methionine
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[HKR]
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BINDING
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399
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399
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S-adenosyl-L-methionine
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N
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Additional information
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Size range |
360-781 amino acids |
Related rules |
None |
Fusion |
None |