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HAMAP rule MF_03154

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General rule information [?]

Accession MF_03154
Dates 27-OCT-2011 (Created)
19-NOV-2022 (Last updated, Version 13)
Name Salvage_MtnD_euk
Scope
Eukaryota
Templates Q99JT9 (MTND_MOUSE); Q03677 (MTND_YEAST); Q9BV57 (MTND_HUMAN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTND
case <FTGroup:1>
Protein name
RecName: Full=Acireductone dioxygenase;
AltName: Full=Acireductone dioxygenase (Fe(2+)-requiring);
Short=ARD';
Short=Fe-ARD;
EC 1.13.11.54;
AltName: Full=Acireductone dioxygenase (Ni(2+)-requiring);
Short=ARD;
Short=Ni-ARD;
EC 1.13.11.53;
else
Protein name
RecName: Full=Probable inactive acireductone dioxygenase;
end case
case <OC:Vertebrata>
Protein name
Full=Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1;
Short=MTCBP-1;
end case
case <OC:Vertebrata>
Gene name
ADI1, MTCBP1
else case <OC:Fungi> or <OC:Dictyostelia>
Gene name
ADI1
end case

Comments [?]

case <FTGroup:1> and <OC:Mammalia>
Function Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
else case <FTGroup:1> and not <OC:Mammalia>
Function Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
end case
case <FTGroup:1>
Catalytic activity RHEA:24504: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
EC 1.13.11.54
RHEA:14161: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
EC 1.13.11.53
Cofactor Fe(2+)
Ni(2+)
Note: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.
end case
case <OC:Mammalia>
Subunit Monomer. Interacts with MMP14.
Subcellular location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
else case <OC:Vertebrata> and not <OC:Mammalia>
Subunit Monomer.
Subcellular location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
else
Subcellular location Cytoplasm. Nucleus.
end case
Similarity Belongs to the acireductone dioxygenase (ARD) family.
case not <FTGroup:1>
Function Probable inactive acireductone dioxygenase.
Caution This enzyme lacks one or more conserved metal-binding sites. It may be non-functional.
end case

Keywords [?]

case <FTGroup:1>
Amino-acid biosynthesis
Dioxygenase
Methionine biosynthesis
Oxidoreductase
Metal-binding
Iron
Nickel
end case
case <OC:Vertebrata>
Cell membrane
Membrane
end case
Cytoplasm
Nucleus

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0005634; Cellular component: nucleus.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0016151; Molecular function: nickel cation binding.
GO:0010308; Molecular function: acireductone dioxygenase (Ni2+-requiring) activity.
GO:0010309; Molecular function: acireductone dioxygenase [iron(II)-requiring] activity.
GO:0019509; Biological process: L-methionine salvage from methylthioadenosine.
end case

Cross-references [?]

Pfam PF03079; ARD; 1;

Features [?]

From: MTND_YEAST (Q03677)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     85     85       /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /ligand_note="for iron-dependent acireductone dioxygenase activity     H   1
BINDING     85     85       /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786" /ligand_note="for nickel-dependent acireductone dioxygenase activity     H   1
BINDING     87     87       /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /ligand_note="for iron-dependent acireductone dioxygenase activity     H   1
BINDING     87     87       /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786" /ligand_note="for nickel-dependent acireductone dioxygenase activity     H   1
BINDING     91     91       /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /ligand_note="for iron-dependent acireductone dioxygenase activity     E   1
BINDING     91     91       /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786" /ligand_note="for nickel-dependent acireductone dioxygenase activity     E   1
BINDING     132     132       /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" /ligand_note="for iron-dependent acireductone dioxygenase activity     H   1
BINDING     132     132       /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786" /ligand_note="for nickel-dependent acireductone dioxygenase activity     H   1
case <OC:Mammalia>
From: MTND_HUMAN (Q03677)
INIT_MET     1     1       Removed     M  
end case

Additional information [?]

Size range 146-344 amino acids
Related rules None
Fusion None


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