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Annotation rule MF_03154 |
General rule information
[?]
Accession |
MF_03154 |
Dates |
27-OCT-2011 (Created) 10-DEC-2019 (Last updated, Version 10) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <FTGroup:1>
Protein name |
RecName:
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Full=1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase;
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EC 1.13.11.54;
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AltName:
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Full=Acireductone dioxygenase (Fe(2+)-requiring);
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Short=ARD;
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Short=Fe-ARD;
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else
Protein name |
RecName:
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Full=1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase homolog;
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EC 1.13.11.-;
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AltName:
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Full=Acireductone dioxygenase homolog;
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Short=ARD;
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end case
case <OC:Vertebrata>
Protein name |
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Full=Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1;
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Short=MTCBP-1;
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|
end case
case <OC:Vertebrata>
else case <OC:Fungi> or <OC:Dictyostelia>
end case
case <OC:Vertebrata>
Function |
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. |
else
Function |
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). |
end case
Catalytic activity |
RHEA:24504: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
EC 1.13.11.54
|
case <FTGroup:1>
Cofactor |
Fe cation Note: Binds 1 Fe cation per monomer. Can also use other divalent metal cations. |
end case
Pathway |
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. |
case <OC:Vertebrata>
Subunit |
Monomer. Interacts with MMP14. |
Subcellular location |
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14. |
else
Subcellular location |
Cytoplasm. Nucleus. |
end case
Similarity |
Belongs to the acireductone dioxygenase (ARD) family. |
case not <FTGroup:1>
Caution |
This enzyme lacks one or more conserved metal-binding sites. It may be non-functional. |
end case
case <FTGroup:1>
end case
case <OC:Vertebrata>
end case
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0010309; Molecular function: acireductone dioxygenase [iron(II)-requiring] activity.
else
GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen.
end case
GO:0019509; Biological process: L-methionine salvage from methylthioadenosine.
From: MTND_YEAST (Q03677) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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METAL
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85
|
|
85
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Iron or nickel
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|
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H
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1
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METAL
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87
|
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87
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Iron or nickel
|
|
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H
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1
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METAL
|
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91
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91
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Iron or nickel
|
|
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E
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1
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METAL
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132
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132
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Iron or nickel
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H
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1
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case <OC:Mammalia>
From: MTND_HUMAN (Q03677) |
INIT_MET
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1
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1
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Removed
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M
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end case
Additional information
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Size range |
146-344 amino acids |
Related rules |
None |
Fusion |
None |