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Annotation rule MF_03154
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General rule information [?]

Accession MF_03154
Dates 27-OCT-2011 (Created)
10-DEC-2019 (Last updated, Version 10)
Name Salvage_MtnD_euk
Scope
Eukaryota
Templates Q03677 (MTND_YEAST); Q9BV57 (MTND_HUMAN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTND
case <FTGroup:1>
Protein name
RecName: Full=1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase;
EC 1.13.11.54;
AltName: Full=Acireductone dioxygenase (Fe(2+)-requiring);
Short=ARD;
Short=Fe-ARD;
else
Protein name
RecName: Full=1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase homolog;
EC 1.13.11.-;
AltName: Full=Acireductone dioxygenase homolog;
Short=ARD;
end case
case <OC:Vertebrata>
Protein name
Full=Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1;
Short=MTCBP-1;
end case
case <OC:Vertebrata>
Gene name
ADI1, MTCBP1
else case <OC:Fungi> or <OC:Dictyostelia>
Gene name
ADI1
end case

Comments [?]

case <OC:Vertebrata>
Function Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
else
Function Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
end case
Catalytic activity RHEA:24504: 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
EC 1.13.11.54
case <FTGroup:1>
Cofactor Fe cation
Note: Binds 1 Fe cation per monomer. Can also use other divalent metal cations.
end case
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.
case <OC:Vertebrata>
Subunit Monomer. Interacts with MMP14.
Subcellular location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
else
Subcellular location Cytoplasm. Nucleus.
end case
Similarity Belongs to the acireductone dioxygenase (ARD) family.
case not <FTGroup:1>
Caution This enzyme lacks one or more conserved metal-binding sites. It may be non-functional.
end case

Keywords [?]

Amino-acid biosynthesis
Cytoplasm
Dioxygenase
Methionine biosynthesis
Nucleus
Oxidoreductase
case <FTGroup:1>
Metal-binding
Iron
end case
case <OC:Vertebrata>
Cell membrane
Membrane
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0005634; Cellular component: nucleus.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0010309; Molecular function: acireductone dioxygenase [iron(II)-requiring] activity.
else
GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen.
end case
GO:0019509; Biological process: L-methionine salvage from methylthioadenosine.

Cross-references [?]

Pfam PF03079; ARD; 1;

Features [?]

From: MTND_YEAST (Q03677)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     85     85       Iron or nickel     H   1
METAL     87     87       Iron or nickel     H   1
METAL     91     91       Iron or nickel     E   1
METAL     132     132       Iron or nickel     H   1
case <OC:Mammalia>
From: MTND_HUMAN (Q03677)
INIT_MET     1     1       Removed     M  
end case

Additional information [?]

Size range 146-344 amino acids
Related rules None
Fusion None


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