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Annotation rule MF_03157 |
General rule information
[?]
Accession |
MF_03157 |
Dates |
14-FEB-2012 (Created) 20-NOV-2019 (Last updated, Version 9) |
Name |
NADHX_dehydratase_euk |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Mammalia>
Protein name |
RecName:
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Full=ATP-dependent (S)-NAD(P)H-hydrate dehydratase;
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EC 4.2.1.93;
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AltName:
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Full=ATP-dependent NAD(P)HX dehydratase;
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AltName:
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Full=Carbohydrate kinase domain-containing protein;
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else
Protein name |
RecName:
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Full=ATP-dependent (S)-NAD(P)H-hydrate dehydratase;
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EC 4.2.1.93;
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AltName:
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Full=ATP-dependent NAD(P)HX dehydratase;
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|
end case
Function |
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. |
Catalytic activity |
RHEA:19017: (6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate
EC 4.2.1.93
|
Cofactor |
Mg(2+) |
case <OC:Fungi>
Subcellular location |
Cytoplasm. |
else case <OC:Mammalia>
Subcellular location |
Mitochondrion. |
end case
case <OC:Mammalia> and not <AnyFeature:TransitM>
Miscellaneous |
This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Similarity |
Belongs to the NnrD/CARKD family. |
case <OC:Fungi>
else case <OC:Mammalia>
end case
GO:0047453; Molecular function: ATP-dependent NAD(P)H-hydrate dehydratase activity.
GO:0046496; Biological process: nicotinamide nucleotide metabolic process.
case <OC:Fungi>
else case <OC:Mammalia>
end case
case <OC:Mammalia>
General |
TransitM; -; 0-1; trigger=yes; |
end case
From: NNRD_BACSU (P94368) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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186
|
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190
|
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ATP
|
|
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K-x(4)
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NP_BIND
|
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206
|
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215
|
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ATP
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x(7)-G-x-G
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REGION
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149
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155
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NAD(P)HX
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x(3)-E-x(3)
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BINDING
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104
|
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104
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NAD(P)HX; via amide nitrogen
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BINDING
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216
|
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216
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NAD(P)HX
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D
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Additional information
[?]
Size range |
295-413 amino acids |
Related rules |
None |
Fusion |
None |