HAMAP rule MF_03162
General rule information
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Accession | MF_03162 |
Dates | 8-JAN-2013 (Created) 19-NOV-2022 (Last updated, Version 10) |
Name | RNA_methyltr_E_TRM7 |
Scope | Eukaryota |
Template | P38238 (TRM7_YEAST) |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Mammalia>
Protein name |
|
end case
case <OC:Saccharomycetales>
Gene name |
|
end case
case <OC:Mammalia>
Gene name |
|
end case
Comments
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Function | Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. |
Catalytic activity | RHEA:42396: cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine
EC 2.1.1.205 |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily. |
Keywords
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Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0008175; Molecular function: tRNA methyltransferase activity.
GO:0002181; Biological process: cytoplasmic translation.
GO:0002128; Biological process: tRNA nucleoside ribose methylation.
GO:0008175; Molecular function: tRNA methyltransferase activity.
GO:0002181; Biological process: cytoplasmic translation.
GO:0002128; Biological process: tRNA nucleoside ribose methylation.
Cross-references
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Pfam | PF01728; FtsJ; 1; |
PIRSF | PIRSF005461; 23S_rRNA_mtase; 1; |
Features
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From: TRM7_YEAST (P38238) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 164 | 164 | Proton acceptor | K | ||||||||
BINDING | 55 | 55 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | 1 | |||||||
BINDING | 57 | 57 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [WF] | 1 | |||||||
BINDING | 83 | 83 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | 1 | |||||||
BINDING | 99 | 99 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [DN] | 1 | |||||||
BINDING | 124 | 124 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | 1 |
Additional information
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