HAMAP rule MF_03162

General rule information [?]

Accession	MF_03162
Dates	8-JAN-2013 (Created) 3-SEP-2024 (Last updated, Version 11)
Name	RNA_methyltr_E_TRM7
Scope(s)	Eukaryota
Template(s)	P38238 (TRM7_YEAST); [ Recover all ]
Triggered by	case c? <OC:Eukaryota> HAMAP; MF_03162 (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TRM7
Protein name	RecName: Full=Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; EC=2.1.1.205; AltName: Full=2'-O-ribose RNA methyltransferase TRM7 homolog;
case <OC:Mammalia>
Protein name	+ AltName: Full=Protein ftsJ homolog 1;
end case
case <OC:Saccharomycetales>
Gene name	Name=TRM7;
end case
case <OC:Mammalia>
Gene name	Name=FTSJ1;
end case

Comments [?]

FUNCTION	Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
CATALYTIC ACTIVITY	Reaction=cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S- adenosyl-L-homocysteine + 2 H(+); Xref=Rhea:RHEA:42396, Rhea:RHEA- COMP:10246, Rhea:RHEA-COMP:10247, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.205;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm

GO:0008175; Molecular function:tRNA methyltransferase activity

GO:0002181; Biological process:cytoplasmic translation

GO:0002128; Biological process:tRNA nucleoside ribose methylation

Cross-references [?]

Pfam	PF01728; FtsJ; 1;
PIRSF	PIRSF005461; 23S_rRNA_mtase; 1;

Features [?]

From: TRM7_YEAST (P38238)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

164

/note="Proton acceptor"

BINDING