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Annotation rule MF_03162 |
General rule information
[?]
Accession |
MF_03162 |
Dates |
8-JAN-2013 (Created) 19-NOV-2022 (Last updated, Version 10) |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase;
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EC 2.1.1.205;
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AltName:
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Full=2'-O-ribose RNA methyltransferase TRM7 homolog;
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case <OC:Mammalia>
Protein name |
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Full=Protein ftsJ homolog 1;
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end case
case <OC:Saccharomycetales>
end case
case <OC:Mammalia>
end case
Function |
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. |
Catalytic activity |
RHEA:42396: cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine
EC 2.1.1.205
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Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily. |
GO:0005737; Cellular component: cytoplasm.
GO:0008175; Molecular function: tRNA methyltransferase activity.
GO:0002181; Biological process: cytoplasmic translation.
GO:0002128; Biological process: tRNA nucleoside ribose methylation.
From: TRM7_YEAST (P38238) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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164
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164
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Proton acceptor
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K
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BINDING
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55
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55
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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G
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1
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BINDING
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57
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57
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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[WF]
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1
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BINDING
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83
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83
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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D
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1
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BINDING
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99
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99
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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[DN]
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1
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BINDING
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124
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124
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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D
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1
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Additional information
[?]
Size range |
244-534 amino acids |
Related rules |
MF_01547 (RLME); MF_03163 (SPB1) |
Fusion |
None |