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Annotation rule MF_03163 |
General rule information
[?]
Accession |
MF_03163 |
Dates |
8-JAN-2013 (Created) 20-NOV-2019 (Last updated, Version 8) |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Fungi>
Protein name |
RecName:
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Full=AdoMet-dependent rRNA methyltransferase ;
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EC 2.1.1.-;
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AltName:
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Full=2'-O-ribose RNA methyltransferase;
|
AltName:
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Full=S-adenosyl-L-methionine-dependent methyltransferase;
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|
else case <OC:Vertebrata>
Protein name |
RecName:
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Full=pre-rRNA processing protein FTSJ3;
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EC 2.1.1.-;
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AltName:
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Full=2'-O-ribose RNA methyltransferase SPB1 homolog;
|
AltName:
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Full=Protein ftsJ homolog 3;
|
AltName:
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Full=Putative rRNA methyltransferase 3;
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|
else
Protein name |
RecName:
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Full=Putative rRNA methyltransferase;
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EC 2.1.1.-;
|
AltName:
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Full=2'-O-ribose RNA methyltransferase SPB1 homolog;
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|
end case
case <OC:Fungi>
Function |
Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. |
Catalytic activity |
RHEA:48628: a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine
|
Subunit |
Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle. |
else case <OC:Vertebrata>
Function |
Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. |
Catalytic activity |
RHEA:48628: a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine
|
Subunit |
Interacts with NIP7. |
else
Function |
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. |
Catalytic activity |
RHEA:48628: a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine
|
end case
Subcellular location |
Nucleus, nucleolus. |
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. |
case <OC:Fungi>
GO:0030687; Cellular component: preribosome, large subunit precursor.
GO:0070039; Molecular function: rRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0008650; Molecular function: rRNA (uridine-2'-O-)-methyltransferase activity.
else case <OC:Vertebrata>
GO:0030688; Cellular component: preribosome, small subunit precursor.
GO:0008649; Molecular function: rRNA methyltransferase activity.
else
GO:0008649; Molecular function: rRNA methyltransferase activity.
end case
GO:0000453; Biological process: enzyme-directed rRNA 2'-O-methylation.
General |
Coiled_coil; -; 0-unlimited; |
From: SPB1_YEAST (P25582) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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159
|
|
159
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Proton acceptor
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|
|
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K
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|
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BINDING
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58
|
|
58
|
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S-adenosyl-L-methionine; via amide nitrogen
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|
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G
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1
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BINDING
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60
|
|
60
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S-adenosyl-L-methionine; via amide nitrogen
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|
|
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[WF]
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1
|
BINDING
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78
|
|
78
|
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S-adenosyl-L-methionine
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|
|
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D
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1
|
BINDING
|
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94
|
|
94
|
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S-adenosyl-L-methionine
|
|
|
|
[DN]
|
|
1
|
BINDING
|
|
119
|
|
119
|
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S-adenosyl-L-methionine
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|
|
|
D
|
|
1
|
Additional information
[?]
Size range |
736-1019 amino acids |
Related rules |
MF_01547 (RLME); MF_03162 (TRM7) |
Fusion |
None |