HAMAP rule MF_03163
General rule information
[?]
Accession | MF_03163 |
Dates | 8-JAN-2013 (Created) 7-FEB-2023 (Last updated, Version 11) |
Name | RNA_methyltr_E_SPB1 |
Scope | Eukaryota |
Templates | P25582 (SPB1_YEAST); Q8IY81 (SPB1_HUMAN): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
case <OC:Fungi>
Protein name |
|
Gene name |
|
else case <OC:Vertebrata>
Protein name |
|
Gene name |
|
else
Protein name |
|
end case
Comments
[?]
case <OC:Fungi>
Function | Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. |
Catalytic activity | RHEA:48628: a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine |
Subunit | Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle. |
else case <OC:Vertebrata>
Function | Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. |
Catalytic activity | RHEA:48628: a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine |
Subunit | Interacts with NIP7. |
else
Function | Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. |
Catalytic activity | RHEA:48628: a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine |
end case
Subcellular location | Nucleus, nucleolus. |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0005730; Cellular component: nucleolus.
case <OC:Fungi>
GO:0030687; Cellular component: preribosome, large subunit precursor.
GO:0070039; Molecular function: rRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0008650; Molecular function: rRNA (uridine-2'-O-)-methyltransferase activity.
GO:0070039; Molecular function: rRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0008650; Molecular function: rRNA (uridine-2'-O-)-methyltransferase activity.
else case <OC:Vertebrata>
GO:0030688; Cellular component: preribosome, small subunit precursor.
GO:0008649; Molecular function: rRNA methyltransferase activity.
GO:0008649; Molecular function: rRNA methyltransferase activity.
else
GO:0008649; Molecular function: rRNA methyltransferase activity.
end case
GO:0031167; Biological process: rRNA methylation.
Cross-references
[?]
Pfam | PF11861; DUF3381; 1; |
PF01728; FtsJ; 1; | |
PF07780; Spb1_C; 1; | |
PF02520; DUF148; 1; | |
PROSITE | PS50312; ASP_RICH; 0-unlimited; |
PS50313; GLU_RICH; 0-unlimited; | |
PS50318; LYS_RICH; 0-unlimited; |
Computed features
[?]
General | Coiled_coil; -; 0-unlimited; |
Features
[?]
From: SPB1_YEAST (P25582) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 159 | 159 | Proton acceptor | K | ||||||||
BINDING | 58 | 58 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | 1 | |||||||
BINDING | 60 | 60 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [WF] | 1 | |||||||
BINDING | 78 | 78 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | 1 | |||||||
BINDING | 94 | 94 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [DN] | 1 | |||||||
BINDING | 119 | 119 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | 1 |
Additional information
[?]