HAMAP rule MF_03164
General rule information
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| Accession | MF_03164 |
| Dates | 13-FEB-2013 (Created) 19-NOV-2022 (Last updated, Version 12) |
| Name | Top6A_euk |
| Scope | Eukaryota; Viridiplantae |
| Templates | Q57815 (TOP6A_METJA); Q9LZ03 (TOP6A_ARATH); A2XFC1 (TOP6A_ORYSI): [Recover all] |
case <OC:Eukaryota>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. |
| Catalytic activity | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
| Cofactor | Mg(2+) |
| Subunit | Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits. |
| Subcellular location | Nucleus. |
| Similarity | Belongs to the TOP6A family. |
Keywords
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Gene Ontology
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GO:0009330; Cellular component: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex.
GO:0005634; Cellular component: nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006265; Biological process: DNA topological change.
GO:0005634; Cellular component: nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006265; Biological process: DNA topological change.
Cross-references
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| Pfam | PF04406; TP6A_N; 1; |
| PRINTS | PR01550; TOP6AFAMILY; 1; |
| PR01552; TPISMRASE6A; 1; | |
| PROSITE | PS50324; SER_RICH; 0-unlimited; |
Features
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| From: TOP6A_METJA (Q57815) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 103 | 103 | Nucleophile | Y | ||||||||
| BINDING | 197 | 197 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | ||||||||
| BINDING | 249 | 249 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
Additional information
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| Size range | 340-453 amino acids |
| Related rules | None |
| Fusion | None |