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HAMAP rule MF_03164

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General rule information [?]

Accession MF_03164
Dates 13-FEB-2013 (Created)
19-NOV-2022 (Last updated, Version 12)
Name Top6A_euk
Eukaryota; Viridiplantae
Templates Q57815 (TOP6A_METJA); Q9LZ03 (TOP6A_ARATH); A2XFC1 (TOP6A_ORYSI): [Recover all]
case <OC:Eukaryota>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA topoisomerase 6 subunit A;
Gene name

Comments [?]

Function Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Catalytic activity Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=;
Cofactor Mg(2+)
Subunit Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits.
Subcellular location Nucleus.
Similarity Belongs to the TOP6A family.

Keywords [?]

Gene Ontology [?]

GO:0009330; Cellular component: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex.
GO:0005634; Cellular component: nucleus.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006265; Biological process: DNA topological change.

Cross-references [?]

Pfam PF04406; TP6A_N; 1;
PR01552; TPISMRASE6A; 1;
PROSITE PS50324; SER_RICH; 0-unlimited;

Features [?]

From: TOP6A_METJA (Q57815)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     103     103       Nucleophile     Y  
BINDING     197     197       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E  
BINDING     249     249       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D  

Additional information [?]

Size range 340-453 amino acids
Related rules None
Fusion None