HAMAP rule MF_03164
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03164 |
| Accession | MF_03164 |
| Dates | 13-FEB-2013 (Created)
19-NOV-2022 (Last updated, Version 13) |
| Name | Top6A_euk |
| Scope(s) |
Eukaryota Viridiplantae |
| Template(s) | Q57815; Q9LZ03; A2XFC1; [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_00132 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TOP6A |
| Protein name | RecName: Full=DNA topoisomerase 6 subunit A; EC=5.6.2.2; |
| Gene name | Name=TOP6A; |
Comments
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| FUNCTION | Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the TOP6A family. |
Keywords
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Gene Ontology
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| GO:0009330; Cellular component:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex |
| GO:0005634; Cellular component:nucleus |
| GO:0003677; Molecular function:DNA binding |
| GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0006265; Biological process:DNA topological change |
Cross-references
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| Pfam | PF04406; TP6A_N; 1; |
| PRINTS | PR01550; TOP6AFAMILY; 1; |
| PRINTS | PR01552; TPISMRASE6A; 1; |
| PROSITE | PS50324; SER_RICH; 0-unlimited; |
Features
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| From: TOP6A_METJA (Q57815) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 103 | 103 | /note="Nucleophile" | Y | ||||||||
| BINDING | 197 | 197 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 249 | 249 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
Additional information
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| Size range | 340-453 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |