![]() |
|
Annotation rule MF_03164 |
Accession | MF_03164 |
Dates | 13-FEB-2013 (Created) 20-NOV-2019 (Last updated, Version 10) |
Name | Top6A_euk |
Scope | Eukaryota; Viridiplantae |
Templates | Q57815 (TOP6A_METJA); Q9LZ03 (TOP6A_ARATH); A2XFC1 (TOP6A_ORYSI): [Recover all] |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. |
Catalytic activity | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
Cofactor | Mg(2+) |
Subunit | Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits. |
Subcellular location | Nucleus. |
Similarity | Belongs to the TOP6A family. |
Pfam | PF04406; TP6A_N; 1; |
PRINTS | PR01550; TOP6AFAMILY; 1; |
PR01552; TPISMRASE6A; 1; | |
PROSITE | PS50324; SER_RICH; 0-unlimited; |
From: TOP6A_METJA (Q57815) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 103 | 103 | Nucleophile | Y | ||||||||
METAL | 197 | 197 | Magnesium | E | ||||||||
METAL | 249 | 249 | Magnesium | D |
Size range | 340-453 amino acids |
Related rules | None |
Fusion | None |