HAMAP rule MF_03165
General rule information
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| Accession | MF_03165 |
| Dates | 13-FEB-2013 (Created) 19-NOV-2022 (Last updated, Version 12) |
| Name | Top6B_plant |
| Scope | Eukaryota; Viridiplantae |
| Templates | O05207 (TOP6B_SACSH); Q9C5V6 (TOP6B_ARATH); B8BDQ4 (TOP6B_ORYSI): [Recover all] |
case <OC:Eukaryota>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP. |
| Catalytic activity | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
| Subunit | Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits. |
| Subcellular location | Nucleus. |
| Similarity | Belongs to the TOP6B family. |
Keywords
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Gene Ontology
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GO:0009330; Cellular component: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex.
GO:0005634; Cellular component: nucleus.
GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0006265; Biological process: DNA topological change.
GO:0005634; Cellular component: nucleus.
GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0006265; Biological process: DNA topological change.
Cross-references
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Features
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| From: TOP6B_SACSH (O05207) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 97 | 98 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [ST]-[KR] | ||||||||
| BINDING (Optional) | 106 | 113 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-x-x-G-[LIV]-G-x-[KSA] | ||||||||
| BINDING (Optional) | 42 | 42 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | N | ||||||||
| BINDING (Optional) | 76 | 76 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | D | ||||||||
| BINDING (Optional) | 427 | 427 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K | ||||||||
Additional information
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| Size range | 475-842 amino acids |
| Related rules | None |
| Fusion | None |