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HAMAP rule MF_03165

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General rule information [?]

Accession MF_03165
Dates 13-FEB-2013 (Created)
19-NOV-2022 (Last updated, Version 12)
Name Top6B_plant
Scope(s) Eukaryota
Template(s) O05207 (TOP6B_SACSH); Q9C5V6 (TOP6B_ARATH); B8BDQ4 (TOP6B_ORYSI); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00322 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TOP6B
Protein name RecName: Full=DNA topoisomerase 6 subunit B;
Gene name Name=TOP6B;

Comments [?]

FUNCTIONComponent of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP.
CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=;
SUBUNITHomodimer. Heterotetramer of two TOP6A and two TOP6B subunits.
SIMILARITYBelongs to the TOP6B family.

Keywords [?]

Gene Ontology [?]

GO:0009330; Cellular component:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0005634; Cellular component:nucleus
GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0006265; Biological process:DNA topological change

Cross-references [?]

Pfam PF02518; HATPase_c; 1;
Pfam PF09239; Topo-VIb_trans; 1;

Features [?]

From: TOP6B_SACSH (O05207)
Key From To Description Tag Condition FTGroup
BINDING 97 98 /ligand="ATP"
BINDING 106 113 /ligand="ATP"
BINDING 42 42 /ligand="ATP"
BINDING 76 76 /ligand="ATP"
BINDING 427 427 /ligand="ATP"

Additional information [?]

Size range 475-842 amino acids
Related rules None
Fusion Nter: None Cter: None

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