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Annotation rule MF_03165
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General rule information [?]

Accession MF_03165
Dates 13-FEB-2013 (Created)
20-NOV-2019 (Last updated, Version 10)
Name Top6B_plant
Scope
Eukaryota; Viridiplantae
Templates O05207 (TOP6B_SACSH); Q9C5V6 (TOP6B_ARATH); B8BDQ4 (TOP6B_ORYSI): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TOP6B
Protein name
RecName: Full=DNA topoisomerase 6 subunit B;
EC 5.6.2.2;
Gene name
TOP6B

Comments [?]

Function Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP.
Catalytic activity Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2;
Subunit Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits.
Subcellular location Nucleus.
Similarity Belongs to the TOP6B family.

Keywords [?]


Gene Ontology [?]

GO:0009330; Cellular component: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex.
GO:0005634; Cellular component: nucleus.
GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0006265; Biological process: DNA topological change.

Cross-references [?]

Pfam PF02518; HATPase_c; 1;
PF09239; Topo-VIb_trans; 1;

Features [?]

From: TOP6B_SACSH (O05207)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     97     98       ATP     [ST]-[KR]  
NP_BIND (Optional)     106     113       ATP     G-x-x-G-[LIV]-G-x-[KSA]  
BINDING (Optional)     42     42       ATP     N  
BINDING (Optional)     76     76       ATP     D  
BINDING (Optional)     427     427       ATP     K  

Additional information [?]

Size range 475-842 amino acids
Related rules None
Fusion None