HAMAP rule MF_03165
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03165 |
| Accession | MF_03165 |
| Dates | 13-FEB-2013 (Created)
19-NOV-2022 (Last updated, Version 12) |
| Name | Top6B_plant |
| Scope(s) |
Eukaryota Viridiplantae |
| Template(s) | O05207 (TOP6B_SACSH); Q9C5V6 (TOP6B_ARATH); B8BDQ4 (TOP6B_ORYSI); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_00322 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TOP6B |
| Protein name | RecName: Full=DNA topoisomerase 6 subunit B; EC=5.6.2.2; |
| Gene name | Name=TOP6B; |
Comments
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| FUNCTION | Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP. |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; |
| SUBUNIT | Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the TOP6B family. |
Keywords
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Gene Ontology
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| GO:0009330; Cellular component:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex |
| GO:0005634; Cellular component:nucleus |
| GO:0005524; Molecular function:ATP binding |
| GO:0003677; Molecular function:DNA binding |
| GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| GO:0006265; Biological process:DNA topological change |
Cross-references
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Features
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| From: TOP6B_SACSH (O05207) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 97 | 98 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[ST]-[KR] | ||||||||
| BINDING | 106 | 113 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-x-G-[LIV]-G-x-[KSA] | ||||||||
| BINDING | 42 | 42 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
| BINDING | 76 | 76 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
| BINDING | 427 | 427 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
Additional information
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| Size range | 475-842 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |