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HAMAP rule MF_03166

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General rule information [?]

Accession MF_03166
Dates 20-FEB-2013 (Created)
1-JUN-2023 (Last updated, Version 9)
Name UDG_euk
Scope(s) Eukaryota
Template(s) P12295 (UNG_ECOLI); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00148 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier UNG
Protein name RecName: Full=Uracil-DNA glycosylase;
case <OC:Vertebrata>
Gene name Name=UNG; Synonyms=UNG1;
else case <OC:Fungi>
Gene name Name=UNG1;
end case

Comments [?]

FUNCTIONExcises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
CATALYTIC ACTIVITY Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=;
case <OC:Mammalia>
SUBUNITMonomer. Interacts with FAM72A.
end case
SUBCELLULAR LOCATIONMitochondrion. Nucleus.
SIMILARITYBelongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.

Keywords [?]

Gene Ontology [?]

GO:0004844; Molecular function:uracil DNA N-glycosylase activity
GO:0006284; Biological process:base-excision repair
GO:0005634; Cellular component:nucleus
GO:0005739; Cellular component:mitochondrion

Cross-references [?]

Pfam PF03167; UDG; 1;
NCBIfam TIGR00628; Ung; 1;

Features [?]

From: UNG_ECOLI (P12295)
Key From To Description Tag Condition FTGroup
ACT_SITE 64 64 /note="Proton acceptor" D

Additional information [?]

Size range 306-359 amino acids
Related rules None
Fusion Nter: None Cter: None

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