HAMAP rule MF_03166
General rule information
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| Accession | MF_03166 |
| Dates | 20-FEB-2013 (Created)
1-JUN-2023 (Last updated, Version 9) |
| Name | UDG_euk |
| Scope(s) |
Eukaryota |
| Template(s) | P12295 (UNG_ECOLI); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_00148 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | UNG |
| Protein name | RecName: Full=Uracil-DNA glycosylase; Short=UDG; EC=3.2.2.27; |
| case <OC:Vertebrata> | |
| Gene name | Name=UNG; Synonyms=UNG1; |
| else case <OC:Fungi> | |
| Gene name | Name=UNG1; |
| end case | |
Comments
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| FUNCTION | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. |
| CATALYTIC ACTIVITY | Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27; |
| case <OC:Mammalia> | |
| SUBUNIT | Monomer. Interacts with FAM72A. |
| end case | |
| SUBCELLULAR LOCATION | Mitochondrion. Nucleus. |
| SIMILARITY | Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. |
Keywords
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Gene Ontology
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| GO:0004844; Molecular function:uracil DNA N-glycosylase activity |
| GO:0006284; Biological process:base-excision repair |
| GO:0005634; Cellular component:nucleus |
| GO:0005739; Cellular component:mitochondrion |
Cross-references
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Features
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| From: UNG_ECOLI (P12295) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 64 | 64 | /note="Proton acceptor" | D | ||||||||
Additional information
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| Size range | 306-359 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |