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Annotation rule MF_03166
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General rule information [?]

Accession MF_03166
Dates 20-FEB-2013 (Created)
20-NOV-2019 (Last updated, Version 8)
Name UDG_euk
Scope
Eukaryota
Template P12295 (UNG_ECOLI)
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
UNG
Protein name
RecName: Full=Uracil-DNA glycosylase;
Short=UDG;
EC 3.2.2.27;
case <OC:Vertebrata>
Gene name
UNG, UNG1
else case <OC:Fungi>
Gene name
UNG1
end case

Comments [?]

Function Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Catalytic activity Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27;
case <OC:Mammalia>
Subunit Monomer. Interacts with FAM72A.
end case
Subcellular location Mitochondrion. Nucleus.
Similarity Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.

Keywords [?]


Gene Ontology [?]

GO:0004844; Molecular function: uracil DNA N-glycosylase activity.
GO:0006284; Biological process: base-excision repair.
GO:0005634; Cellular component: nucleus.
GO:0005739; Cellular component: mitochondrion.

Cross-references [?]

Pfam PF03167; UDG; 1;
TIGRFAMs TIGR00628; Ung; 1;
PROSITE PS00130; U_DNA_GLYCOSYLASE; 1;

Features [?]

From: UNG_ECOLI (P12295)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     64     64       Proton acceptor     D  

Additional information [?]

Size range 306-359 amino acids
Related rules None
Fusion None