HAMAP rule MF_03169
General rule information
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Accession | MF_03169 |
Dates | 11-MAR-2013 (Created) 19-NOV-2022 (Last updated, Version 12) |
Name | Adenylate_kinase_AK3 |
Scope | Eukaryota |
Templates | P08760 (KAD3_BOVIN); Q9UIJ7 (KAD3_HUMAN); P26364 (KAD3_YEAST): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Mammalia>
Protein name |
|
else case <OC:Vertebrata>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
end case
case <OC:Insecta>
Gene name |
|
end case
case <OC:Fungi>
Gene name |
|
end case
Comments
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Function | Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. |
Catalytic activity | RHEA:13749: a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP
EC 2.7.4.10 |
Subunit | Monomer. |
Subcellular location | Mitochondrion matrix. |
Domain | Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis. |
Similarity | Belongs to the adenylate kinase family. AK3 subfamily. |
Keywords
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Gene Ontology
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GO:0005759; Cellular component: mitochondrial matrix.
GO:0046899; Molecular function: nucleoside triphosphate adenylate kinase activity.
GO:0006172; Biological process: ADP biosynthetic process.
GO:0046033; Biological process: AMP metabolic process.
GO:0046039; Biological process: GTP metabolic process.
GO:0046041; Biological process: ITP metabolic process.
GO:0046899; Molecular function: nucleoside triphosphate adenylate kinase activity.
GO:0006172; Biological process: ADP biosynthetic process.
GO:0046033; Biological process: AMP metabolic process.
GO:0046039; Biological process: GTP metabolic process.
GO:0046041; Biological process: ITP metabolic process.
Cross-references
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PROSITE | PS00113; ADENYLATE_KINASE; 1; |
Pfam | PF00406; ADK; 1; |
PF05191; ADK_lid; 1; | |
PRINTS | PR00094; ADENYLTKNASE; 1; |
TIGRFAMs | TIGR01351; adk; 1; |
Features
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From: KAD3_BOVIN (P08760) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 17 | 22 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | G-x-G-K-G-T | ||||||||
BINDING | 64 | 66 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | x-L-[VMIL] | ||||||||
BINDING | 91 | 94 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | G-F-P-R | ||||||||
BINDING | 137 | 138 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | [VI]-Y | ||||||||
REGION | 37 | 66 | NMPbind | |||||||||
REGION | 127 | 164 | LID | |||||||||
BINDING | 38 | 38 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | [ST] | ||||||||
BINDING | 43 | 43 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | R | ||||||||
BINDING | 98 | 98 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | Q | ||||||||
BINDING | 128 | 128 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | R | ||||||||
BINDING | 161 | 161 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | R | ||||||||
BINDING | 172 | 172 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | R | ||||||||
BINDING | 201 | 201 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | [ST] |
case <OC:Mammalia>
end case
Additional information
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Size range | 206-273 amino acids |
Related rules | MF_00235 (KAD); MF_03168 (KAD2); MF_03170 (KAD4 supersedes the current rule); MF_03171 (KAD1); MF_03172 (KCY) |
Fusion | None |