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HAMAP rule MF_03169

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General rule information [?]

Accession MF_03169
Dates 11-MAR-2013 (Created)
1-JUN-2023 (Last updated, Version 13)
Name Adenylate_kinase_AK3
Scope(s) Eukaryota
Template(s) P08760 (KAD3_BOVIN); Q9UIJ7 (KAD3_HUMAN); P26364 (KAD3_YEAST); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_03169 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KAD3
case <OC:Mammalia>
Protein name RecName: Full=GTP:AMP phosphotransferase AK3, mitochondrial;
                 EC=2.7.4.10;
AltName: Full=Adenylate kinase 3;
                 Short=AK 3;
AltName: Full=Adenylate kinase 3 alpha-like 1;
else case <OC:Vertebrata>
Protein name RecName: Full=GTP:AMP phosphotransferase AK3, mitochondrial;
                 EC=2.7.4.10;
AltName: Full=Adenylate kinase 3;
                 Short=AK 3;
else
Protein name RecName: Full=GTP:AMP phosphotransferase, mitochondrial;
                 EC=2.7.4.10;
AltName: Full=Adenylate kinase 3;
                 Short=AK 3;
end case
case <OC:Vertebrata>
Gene name Name=AK3;
end case
case <OC:Insecta>
Gene name Name=Adk3;
end case
case <OC:Fungi>
Gene name Name=ADK2;
end case

Comments [?]

FUNCTIONInvolved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
CATALYTIC ACTIVITY Reaction=a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'- diphosphate + ADP; Xref=Rhea:RHEA:13749, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.10;
SUBUNITMonomer.
SUBCELLULAR LOCATIONMitochondrion matrix.
DOMAINConsists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
SIMILARITYBelongs to the adenylate kinase family. AK3 subfamily.

Keywords [?]

GTP-binding
Kinase
Mitochondrion
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0005759; Cellular component:mitochondrial matrix
GO:0046899; Molecular function:nucleoside triphosphate adenylate kinase activity
GO:0006172; Biological process:ADP biosynthetic process
GO:0046033; Biological process:AMP metabolic process
GO:0046039; Biological process:GTP metabolic process
GO:0046041; Biological process:ITP metabolic process

Cross-references [?]

PROSITE PS00113; ADENYLATE_KINASE; 1;
Pfam PF00406; ADK; 1;
Pfam PF05191; ADK_lid; 1;
PRINTS PR00094; ADENYLTKNASE; 1;
NCBIfam TIGR01351; adk; 1;

Features [?]

From: KAD3_BOVIN (P08760)
Key From To Description Tag Condition FTGroup
BINDING 17 22 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 G-x-G-K-G-T
BINDING 64 66 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"		 x-L-[VMIL]
BINDING 91 94 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"		 G-F-P-R
BINDING 137 138 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 [VI]-Y
REGION 37 66 /note="NMPbind"
REGION 127 164 /note="LID"
BINDING 38 38 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"		 [ST]
BINDING 43 43 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"		 R
BINDING 98 98 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"		 Q
BINDING 128 128 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 R
BINDING 161 161 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"		 R
BINDING 172 172 /ligand="AMP"
/ligand_id="ChEBI:CHEBI:456215"		 R
BINDING 201 201 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 [ST]
case <OC:Mammalia>
INIT_MET 1 1 /note="Removed" M
end case

Additional information [?]

Size range 206-273 amino acids
Related rules MF_00235
MF_03168
MF_03170
MF_03171
MF_03172
Fusion Nter: None Cter: None



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