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Annotation rule MF_03169
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General rule information [?]

Accession MF_03169
Dates 11-MAR-2013 (Created)
20-NOV-2019 (Last updated, Version 10)
Name Adenylate_kinase_AK3
Scope
Eukaryota
Templates P08760 (KAD3_BOVIN); Q9UIJ7 (KAD3_HUMAN); P26364 (KAD3_YEAST): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KAD3
case <OC:Mammalia>
Protein name
RecName: Full=GTP:AMP phosphotransferase AK3, mitochondrial;
EC 2.7.4.10;
AltName: Full=Adenylate kinase 3;
Short=AK 3;
AltName: Full=Adenylate kinase 3 alpha-like 1;
else case <OC:Vertebrata>
Protein name
RecName: Full=GTP:AMP phosphotransferase AK3, mitochondrial;
EC 2.7.4.10;
AltName: Full=Adenylate kinase 3;
Short=AK 3;
else
Protein name
RecName: Full=GTP:AMP phosphotransferase, mitochondrial;
EC 2.7.4.10;
AltName: Full=Adenylate kinase 3;
Short=AK 3;
end case
case <OC:Vertebrata>
Gene name
AK3
end case
case <OC:Insecta>
Gene name
Adk3
end case
case <OC:Fungi>
Gene name
ADK2
end case

Comments [?]

Function Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
Catalytic activity RHEA:13749: a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP
EC 2.7.4.10
Subunit Monomer.
Subcellular location Mitochondrion matrix.
Domain Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
Similarity Belongs to the adenylate kinase family. AK3 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005759; Cellular component: mitochondrial matrix.
GO:0046899; Molecular function: nucleoside triphosphate adenylate kinase activity.
GO:0006172; Biological process: ADP biosynthetic process.
GO:0046033; Biological process: AMP metabolic process.
GO:0046039; Biological process: GTP metabolic process.
GO:0046041; Biological process: ITP metabolic process.

Cross-references [?]

PROSITE PS00113; ADENYLATE_KINASE; 1;
Pfam PF00406; ADK; 1;
PF05191; ADK_lid; 1;
PRINTS PR00094; ADENYLTKNASE; 1;
TIGRFAMs TIGR01351; adk; 1;

Features [?]

From: KAD3_BOVIN (P08760)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     17     22       GTP     G-x-G-K-G-T  
NP_BIND     64     66       AMP     x-L-[VMIL]  
NP_BIND     91     94       AMP     G-F-P-R  
NP_BIND     137     138       GTP     [VI]-Y  
REGION     37     66       NMPbind        
REGION     127     164       LID        
BINDING     38     38       AMP     [ST]  
BINDING     43     43       AMP     R  
BINDING     98     98       AMP     Q  
BINDING     128     128       GTP     R  
BINDING     161     161       AMP     R  
BINDING     172     172       AMP     R  
BINDING     201     201       GTP; via carbonyl oxygen     [ST]  
case <OC:Mammalia>
INIT_MET     1     1       Removed     M  
end case

Additional information [?]

Size range 206-273 amino acids
Related rules MF_00235 (KAD); MF_03168 (KAD2); MF_03170 (KAD4 supersedes the current rule); MF_03171 (KAD1); MF_03172 (KCY)
Fusion None