HAMAP rule MF_03171
General rule information
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Accession | MF_03171 |
Dates | 11-MAR-2013 (Created) 1-JUN-2023 (Last updated, Version 13) |
Name | Adenylate_kinase_AK1 |
Scope | Eukaryota; Metazoa |
Templates | P00568 (KAD1_HUMAN); P00571 (KAD1_PIG): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Vertebrata>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
end case
Comments
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case <OC:Vertebrata>
Function | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. |
Catalytic activity | RHEA:44640: a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6 |
RHEA:18113: a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6 |
else
Function | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. |
end case
Catalytic activity | RHEA:12973: AMP + ATP = 2 ADP
EC 2.7.4.3 |
Subunit | Monomer. |
Subcellular location | Cytoplasm. |
Domain | Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. |
Similarity | Belongs to the adenylate kinase family. AK1 subfamily. |
Keywords
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case <FTTag:acetyl>
end case
Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0004017; Molecular function: adenylate kinase activity.
GO:0006172; Biological process: ADP biosynthetic process.
GO:0046033; Biological process: AMP metabolic process.
GO:0046034; Biological process: ATP metabolic process.
GO:0004017; Molecular function: adenylate kinase activity.
GO:0006172; Biological process: ADP biosynthetic process.
GO:0046033; Biological process: AMP metabolic process.
GO:0046034; Biological process: ATP metabolic process.
Cross-references
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PROSITE | PS00113; ADENYLATE_KINASE; 1; |
Pfam | PF00406; ADK; 1; |
PRINTS | PR00094; ADENYLTKNASE; 1; |
NCBIfam | TIGR01360; aden_kin_iso1; 1; |
Features
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From: KAD1_HUMAN (P00568) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 18 | 23 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-S-G-K-G-T | ||||||||
BINDING | 65 | 67 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | x-L-V | ||||||||
BINDING | 94 | 97 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | G-Y-P-R | ||||||||
REGION | 38 | 67 | NMPbind | |||||||||
REGION | 131 | 141 | LID | |||||||||
BINDING | 39 | 39 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | [ST] | ||||||||
BINDING | 44 | 44 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | R | ||||||||
BINDING | 101 | 101 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | Q | ||||||||
BINDING | 132 | 132 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R | ||||||||
BINDING | 138 | 138 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | R | ||||||||
BINDING | 149 | 149 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | R | ||||||||
BINDING | 177 | 177 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 |
case <OC:Mammalia>
end case
Additional information
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Size range | 193-211 amino acids |
Related rules | MF_00235 (KAD); MF_03168 (KAD2); MF_03169 (KAD3); MF_03170 (KAD4); MF_03172 (KCY) |
Fusion | None |