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Annotation rule MF_03171
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General rule information [?]

Accession MF_03171
Dates 11-MAR-2013 (Created)
20-NOV-2019 (Last updated, Version 10)
Name Adenylate_kinase_AK1
Scope
Eukaryota; Metazoa
Templates P00568 (KAD1_HUMAN); P00571 (KAD1_PIG): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KAD1
case <OC:Vertebrata>
Protein name
RecName: Full=Adenylate kinase isoenzyme 1;
Short=AK 1;
EC 2.7.4.3;
EC 2.7.4.6;
AltName: Full=ATP-AMP transphosphorylase 1;
AltName: Full=ATP:AMP phosphotransferase;
AltName: Full=Adenylate monophosphate kinase;
AltName: Full=Myokinase;
else
Protein name
RecName: Full=Adenylate kinase isoenzyme 1;
Short=AK 1;
EC 2.7.4.3;
AltName: Full=ATP-AMP transphosphorylase 1;
AltName: Full=ATP:AMP phosphotransferase;
AltName: Full=Adenylate monophosphate kinase;
end case
case <OC:Vertebrata>
Gene name
AK1
end case

Comments [?]

case <OC:Vertebrata>
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Catalytic activity RHEA:44640: a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6
RHEA:18113: a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6
else
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
end case
Catalytic activity RHEA:12973: AMP + ATP = 2 ADP
EC 2.7.4.3
Subunit Monomer.
Subcellular location Cytoplasm.
Domain Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Similarity Belongs to the adenylate kinase family. AK1 subfamily.

Keywords [?]

case <FTTag:acetyl>
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0004017; Molecular function: adenylate kinase activity.
GO:0006172; Biological process: ADP biosynthetic process.
GO:0046033; Biological process: AMP metabolic process.
GO:0046034; Biological process: ATP metabolic process.

Cross-references [?]

PROSITE PS00113; ADENYLATE_KINASE; 1;
Pfam PF00406; ADK; 1;
PRINTS PR00094; ADENYLTKNASE; 1;
TIGRFAMs TIGR01360; aden_kin_iso1; 1;

Features [?]

From: KAD1_HUMAN (P00568)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     18     23       ATP     G-S-G-K-G-T  
NP_BIND     65     67       AMP     x-L-V  
NP_BIND     94     97       AMP     G-Y-P-R  
REGION     38     67       NMPbind        
REGION     131     141       LID        
BINDING     39     39       AMP     [ST]  
BINDING     44     44       AMP     R  
BINDING     101     101       AMP     Q  
BINDING     132     132       ATP     R  
BINDING     138     138       AMP     R  
BINDING     149     149       AMP     R  
BINDING     177     177       ATP; via carbonyl oxygen        
case <OC:Mammalia>
MOD_RES     1     1       N-acetylmethionine   acetyl   M  
end case

Additional information [?]

Size range 193-211 amino acids
Related rules MF_00235 (KAD); MF_03168 (KAD2); MF_03169 (KAD3); MF_03170 (KAD4); MF_03172 (KCY)
Fusion None