HAMAP rule MF_03172
General rule information
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Accession | MF_03172 |
Dates | 15-MAR-2013 (Created) 1-JUN-2023 (Last updated, Version 17) |
Name | Adenylate_kinase_UMP_CMP_kin |
Scope | Eukaryota |
Templates | P15700 (KCY_YEAST); P20425 (KCY_DICDI); P30085 (KCY_HUMAN): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Vertebrata>
Protein name |
|
else case <OC:Fungi>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
else case <OC:Saccharomycotina>
Gene name |
|
else case <OC:Dictyostelia>
Gene name |
|
end case
Comments
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case <OC:Vertebrata>
Function | Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. |
Catalytic activity | RHEA:11600: ATP + CMP = ADP + CDP
EC 2.7.4.14 |
RHEA:25094: ATP + dCMP = ADP + dCDP
EC 2.7.4.14 |
|
RHEA:44640: a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6 |
|
RHEA:18113: a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6 |
else case <OC:Fungi>
Function | Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. |
else
Function | Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. |
Catalytic activity | RHEA:11600: ATP + CMP = ADP + CDP
EC 2.7.4.14 |
RHEA:25094: ATP + dCMP = ADP + dCDP
EC 2.7.4.14 |
end case
Catalytic activity | RHEA:24400: ATP + UMP = ADP + UDP
EC 2.7.4.14 |
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per monomer. |
Subunit | Monomer. |
case <OC:Fungi>
Subcellular location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. |
else case <OC:Vertebrata>
Subcellular location | Nucleus. Cytoplasm. Note=Predominantly nuclear. |
else
Subcellular location | Cytoplasm. Nucleus. |
end case
Domain | Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. |
Similarity | Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. |
Keywords
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Gene Ontology
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case not <OC:Fungi>
GO:0004127; Molecular function: cytidylate kinase activity.
end case
GO:0009041; Molecular function: UMP/dUMP kinase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
Cross-references
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PROSITE | PS00113; ADENYLATE_KINASE; 1; |
Pfam | PF00406; ADK; 1; |
PRINTS | PR00094; ADENYLTKNASE; 1; |
NCBIfam | TIGR01359; UMP_CMP_kin_fam; 1; |
Features
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From: KCY_YEAST (P15700) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 26 | 31 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-x-G-K-G-T | ||||||||
BINDING | 74 | 76 | /ligand="a ribonucleoside 5'-phosphate" /ligand_id="ChEBI:CHEBI:58043 | x-[IL]-[VL] | ||||||||
BINDING | 104 | 107 | /ligand="a ribonucleoside 5'-phosphate" /ligand_id="ChEBI:CHEBI:58043 | G-[FY]-P-R | ||||||||
REGION | 46 | 76 | NMPbind | |||||||||
REGION | 141 | 151 | LID | |||||||||
BINDING | 52 | 52 | /ligand="a ribonucleoside 5'-phosphate" /ligand_id="ChEBI:CHEBI:58043 | R |
case <OC:Fungi>
end case
case not <OC:Fungi>
From: KCY_DICDI (P20425) | ||||||||||||
BINDING | 98 | 98 | /ligand="CMP" /ligand_id="ChEBI:CHEBI:60377 | N |
end case
Additional information
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Size range | 191-231 amino acids |
Related rules | MF_00235 (KAD); MF_03168 (KAD2); MF_03169 (KAD3); MF_03170 (KAD4); MF_03171 (KAD1) |
Fusion | None |