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HAMAP rule MF_03177

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General rule information [?]

Accession MF_03177
Dates 31-JUL-2013 (Created)
19-NOV-2022 (Last updated, Version 9)
Name RRM3
Scope(s) Eukaryota
Template(s) P38766 (RRM3_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03177 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RRM3
RecName: Full=ATP-dependent DNA helicase RRM3;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/"></a>;<br /> AltName: Full=rDNA recombination mutation protein 3;
Gene name Name=RRM3;

Comments [?]

FUNCTION5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.
CATALYTIC ACTIVITY Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=;
SUBCELLULAR LOCATIONNucleus. Chromosome, telomere.
SIMILARITYBelongs to the helicase family. PIF1 subfamily.

Keywords [?]

DNA damage
DNA repair
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>

Gene Ontology [?]

GO:0005657; Cellular component:replication fork
GO:0000781; Cellular component:chromosome, telomeric region
GO:0005524; Molecular function:ATP binding
GO:0043139; Molecular function:5'-3' DNA helicase activity
GO:0051880; Molecular function:G-quadruplex DNA binding
GO:0006260; Biological process:DNA replication
GO:0006281; Biological process:DNA repair
GO:0000002; Biological process:mitochondrial genome maintenance

Cross-references [?]

Pfam PF05970; PIF1; 1;

Features [?]

From: RRM3_YEAST (P38766)
Key From To Description Tag Condition FTGroup
BINDING 254 261 /ligand="ATP"
DNA_BIND 682 701 [QH]-x-Y-V-A-[LI]-S-R-[AV]-x(5)-[LIV]-[QERH]-[LIV]-x(2)-F

Additional information [?]

Size range 588-761 amino acids
Related rules MF_03176
Fusion Nter: None Cter: None

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