HAMAP rule MF_03177
General rule information
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| Accession | MF_03177 |
| Dates | 31-JUL-2013 (Created) 19-NOV-2022 (Last updated, Version 9) |
| Name | RRM3 |
| Scope | Eukaryota; Saccharomycetales |
| Template | P38766 (RRM3_YEAST) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low. |
| Catalytic activity | RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.12 |
| Subcellular location | Nucleus. Chromosome, telomere. |
| Similarity | Belongs to the helicase family. PIF1 subfamily. |
Keywords
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ATP-binding
Chromosome
DNA damage
DNA repair
DNA-binding
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Telomere
Chromosome
DNA damage
DNA repair
DNA-binding
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Telomere
Gene Ontology
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GO:0005657; Cellular component: replication fork.
GO:0000781; Cellular component: chromosome, telomeric region.
GO:0005524; Molecular function: ATP binding.
GO:0043139; Molecular function: 5'-3' DNA helicase activity.
GO:0051880; Molecular function: G-quadruplex DNA binding.
GO:0006260; Biological process: DNA replication.
GO:0006281; Biological process: DNA repair.
GO:0000002; Biological process: mitochondrial genome maintenance.
GO:0000781; Cellular component: chromosome, telomeric region.
GO:0005524; Molecular function: ATP binding.
GO:0043139; Molecular function: 5'-3' DNA helicase activity.
GO:0051880; Molecular function: G-quadruplex DNA binding.
GO:0006260; Biological process: DNA replication.
GO:0006281; Biological process: DNA repair.
GO:0000002; Biological process: mitochondrial genome maintenance.
Cross-references
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| Pfam | PF05970; PIF1; 1; |
Features
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| From: RRM3_YEAST (P38766) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 254 | 261 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-x-A-G-T-G-K-S | ||||||||
| DNA_BIND | 682 | 701 | [QH]-x-Y-V-A-[LI]-S-R-[AV]-x(5)-[LIV]-[QERH]-[LIV]-x(2)-F | |||||||||
Additional information
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| Size range | 588-761 amino acids |
| Related rules | MF_03176 (PIF1) |
| Fusion | None |