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HAMAP rule MF_03177

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General rule information [?]

Accession MF_03177
Dates 31-JUL-2013 (Created)
19-NOV-2022 (Last updated, Version 9)
Name RRM3
Eukaryota; Saccharomycetales
Template P38766 (RRM3_YEAST)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=ATP-dependent DNA helicase RRM3;
AltName: Full=rDNA recombination mutation protein 3;
Gene name

Comments [?]

Function 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.
Catalytic activity RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
Subcellular location Nucleus. Chromosome, telomere.
Similarity Belongs to the helicase family. PIF1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005657; Cellular component: replication fork.
GO:0000781; Cellular component: chromosome, telomeric region.
GO:0005524; Molecular function: ATP binding.
GO:0043139; Molecular function: 5'-3' DNA helicase activity.
GO:0051880; Molecular function: G-quadruplex DNA binding.
GO:0006260; Biological process: DNA replication.
GO:0006281; Biological process: DNA repair.
GO:0000002; Biological process: mitochondrial genome maintenance.

Cross-references [?]

Pfam PF05970; PIF1; 1;

Features [?]

From: RRM3_YEAST (P38766)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     254     261       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-x-A-G-T-G-K-S  
DNA_BIND     682     701             [QH]-x-Y-V-A-[LI]-S-R-[AV]-x(5)-[LIV]-[QERH]-[LIV]-x(2)-F  

Additional information [?]

Size range 588-761 amino acids
Related rules MF_03176 (PIF1)
Fusion None