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Annotation rule MF_03178 |
General rule information
[?]
Accession |
MF_03178 |
Dates |
24-JUL-2013 (Created) 20-NOV-2019 (Last updated, Version 8) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=NADPH-dependent diflavin oxidoreductase 1;
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EC 1.18.1.-;
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AltName:
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Full=NADPH-dependent FMN and FAD-containing oxidoreductase;
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case <OC:Fungi>
else case <OC:Vertebrata>
end case
case <OC:Fungi>
Function |
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of @gn(DRE2). Positively controls H(2)O(2)-induced cell death. |
Subunit |
Interacts with @gn(DRE2). |
Subcellular location |
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure. |
else case <OC:Vertebrata>
Function |
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of @gn(CIAPIN1). |
Subunit |
Interacts with @gn(CIAPIN1). Interacts with @gn(DCPS). |
Subcellular location |
Cytoplasm, perinuclear region. Note=Concentrated in perinuclear structure. |
else
Function |
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. |
Subcellular location |
Cytoplasm. |
end case
Cofactor |
FAD |
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FMN |
Similarity |
Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. |
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In the N-terminal section; belongs to the flavodoxin family. |
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In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. |
case <OC:Fungi>
end case
case <OC:Fungi>
else case <OC:Vertebrata>
GO:0048471; Cellular component: perinuclear region of cytoplasm.
end case
GO:0005737; Cellular component: cytoplasm.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0010181; Molecular function: FMN binding.
GO:0050661; Molecular function: NADP binding.
GO:0016651; Molecular function: oxidoreductase activity, acting on NAD(P)H.
GO:0016226; Biological process: iron-sulfur cluster assembly.
From: NDOR1_HUMAN (Q9UHB4) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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6
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150
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Flavodoxin-like
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NP_BIND
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12
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17
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FMN
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[ST]-[QE]-[ST]-G-[TN]-[AS]
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NP_BIND
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59
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62
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FMN
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[AS]-T-x-G
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NP_BIND
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97
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106
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FMN
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[LIVC]-G-D-[ST]-[ST]-Y-x-[KR]-[FY]-[NC]
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NP_BIND
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382
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385
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FAD
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R-x-[FY]-S
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NP_BIND
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416
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419
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FAD
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G-[LIV]-[CL]-[ST]
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NP_BIND
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515
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516
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NADP
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S-R
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NP_BIND
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521
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525
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NADP
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x(2)-Y-V-Q
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BINDING
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132
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132
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FMN
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[DE]
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BINDING
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350
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350
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FAD
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R
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BINDING
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460
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460
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NADP
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T
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BINDING (Optional)
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558
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558
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NADP
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D
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BINDING
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596
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596
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FAD
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W
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Additional information
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Size range |
575-688 amino acids |
Related rules |
None |
Fusion |
None |