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Annotation rule MF_03188
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General rule information [?]

Accession MF_03188
Dates 17-FEB-2015 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Methyltr_EFM4
Scope
Eukaryota
Template P40516 (EFM4_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Vertebrata>
Identifier
EFMT2
Protein name
RecName: Full=EEF1A lysine methyltransferase 2;
EC 2.1.1.-;
AltName: Full=Methyltransferase-like protein 10;
AltName: Full=Protein-lysine N-methyltransferase METTL10;
Gene name
EEF1AKMT2, METTL10
else case <OC:Fungi>
Identifier
EFM4
Protein name
RecName: Full=Protein-lysine N-methyltransferase ;
EC 2.1.1.-;
AltName: Full=Elongation factor methyltransferase 4;
Gene name
EFM4
else
Protein name
RecName: Full=Protein-lysine N-methyltransferase ;
EC 2.1.1.-;
end case

Comments [?]

case <OC:Vertebrata>
Function Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.
Subcellular location Cytoplasm. Nucleus.
else case <OC:Fungi>
Function S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.
Subcellular location Cytoplasm.
else
Function S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
Subcellular location Cytoplasm.
end case
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.

Keywords [?]

case <OC:Vertebrata>
Nucleus
end case
case <OC:Fungi>
Transport
end case
Cytoplasm
Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

case <OC:Vertebrata>
GO:0005634; Cellular component: nucleus.
end case
case <OC:Fungi>
GO:0016192; Biological process: vesicle-mediated transport.
end case
GO:0005737; Cellular component: cytoplasm.
GO:0016279; Molecular function: protein-lysine N-methyltransferase activity.
GO:0018022; Biological process: peptidyl-lysine methylation.

Cross-references [?]

Pfam PF13847; Methyltransf_31; 1;

Additional information [?]

Size range 210-373 amino acids
Related rules None
Fusion None


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