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HAMAP rule MF_03188

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General rule information [?]

Accession MF_03188
Dates 17-FEB-2015 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Methyltr_EFM4
Scope(s) Eukaryota
Template(s) P40516 (EFM4_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03188 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Vertebrata>
Identifier EFMT2
Protein name RecName: Full=EEF1A lysine methyltransferase 2;
                 EC=2.1.1.-;
AltName: Full=Methyltransferase-like protein 10;
AltName: Full=Protein-lysine N-methyltransferase METTL10;
Gene name Name=EEF1AKMT2; Synonyms=METTL10;
else case <OC:Fungi>
Identifier EFM4
Protein name RecName: Full=Protein-lysine N-methyltransferase ;
                 EC=2.1.1.-;
AltName: Full=Elongation factor methyltransferase 4;
Gene name Name=EFM4;
else
Protein name RecName: Full=Protein-lysine N-methyltransferase ;
                 EC=2.1.1.-;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONProtein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.
SUBCELLULAR LOCATIONCytoplasm. Nucleus.
else case <OC:Fungi>
FUNCTIONS-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.
SUBCELLULAR LOCATIONCytoplasm.
else
FUNCTIONS-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha.
SUBCELLULAR LOCATIONCytoplasm.
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.

Keywords [?]

case <OC:Vertebrata>
Nucleus
end case
case <OC:Fungi>
Transport
end case
Cytoplasm
Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

case <OCellular component:Vertebrata>
GO:0005634; Cellular component:nucleus
end case
case <OCellular component:Fungi>
GO:0016192; Biological process:vesicle-mediated transport
end case
GO:0005737; Cellular component:cytoplasm
GO:0016279; Molecular function:protein-lysine N-methyltransferase activity
GO:0018022; Biological process:peptidyl-lysine methylation

Cross-references [?]

Pfam PF13847; Methyltransf_31; 1;

Features [?]


Additional information [?]

Size range 210-373 amino acids
Related rules None
Fusion Nter: None Cter: None



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