HAMAP rule MF_03188
General rule information
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| Accession | MF_03188 |
| Dates | 17-FEB-2015 (Created)
20-NOV-2019 (Last updated, Version 4) |
| Name | Methyltr_EFM4 |
| Scope(s) |
Eukaryota |
| Template(s) | P40516 (EFM4_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03188 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Vertebrata> | |
| Identifier | EFMT2 |
| Protein name | RecName: Full=EEF1A lysine methyltransferase 2; EC=2.1.1.-; AltName: Full=Methyltransferase-like protein 10; AltName: Full=Protein-lysine N-methyltransferase METTL10; |
| Gene name | Name=EEF1AKMT2; Synonyms=METTL10; |
| else case <OC:Fungi> | |
| Identifier | EFM4 |
| Protein name | RecName: Full=Protein-lysine N-methyltransferase EC=2.1.1.-; AltName: Full=Elongation factor methyltransferase 4; |
| Gene name | Name=EFM4; |
| else | |
| Protein name | RecName: Full=Protein-lysine N-methyltransferase EC=2.1.1.-; |
| end case | |
Comments
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| case <OC:Vertebrata> | |
| FUNCTION | Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. |
| SUBCELLULAR LOCATION | Cytoplasm. Nucleus. |
| else case <OC:Fungi> | |
| FUNCTION | S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| else | |
| FUNCTION | S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. |
Keywords
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| case <OC:Vertebrata> | |
| Nucleus | |
| end case | |
| case <OC:Fungi> | |
| Transport | |
| end case | |
| Cytoplasm | |
| Methyltransferase | |
| S-adenosyl-L-methionine | |
| Transferase | |
Gene Ontology
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| case <OCellular component:Vertebrata> | |
| GO:0005634; Cellular component:nucleus | |
| end case | |
| case <OCellular component:Fungi> | |
| GO:0016192; Biological process:vesicle-mediated transport | |
| end case | |
| GO:0005737; Cellular component:cytoplasm | |
| GO:0016279; Molecular function:protein-lysine N-methyltransferase activity | |
| GO:0018022; Biological process:peptidyl-lysine methylation | |
Cross-references
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| Pfam | PF13847; Methyltransf_31; 1; |
Features
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Additional information
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| Size range | 210-373 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |