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Annotation rule MF_03190
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General rule information [?]

Accession MF_03190
Dates 11-MAR-2015 (Created)
24-JAN-2020 (Last updated, Version 11)
Name UbiG_COQ3_euk
Scope
Eukaryota
Template P27680 (COQ3_YEAST)
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COQ3
Protein name
RecName: Full=Ubiquinone biosynthesis O-methyltransferase, mitochondrial;
AltName: Full=3-demethylubiquinol 3-O-methyltransferase;
EC 2.1.1.64;
AltName: Full=Polyprenyldihydroxybenzoate methyltransferase;
EC 2.1.1.114;
case <OC:Saccharomycotina>
Protein name
Full=3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase;
Short=DHHB methyltransferase;
Short=DHHB-MT;
Short=DHHB-MTase;
AltName: Full=3-demethylubiquinone-6 3-O-methyltransferase;
AltName: Full=Hexaprenyldihydroxybenzoate methyltransferase;
end case
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
Gene name
COQ3
else case <OC:Drosophilidae>
Gene name
Coq3
else case <OC:Insecta> or <OC:Dictyostelia>
Gene name
coq3
else case <OC:Caenorhabditis>
Gene name
coq-3
end case

Comments [?]

Function O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Catalytic activity RHEA:44452: 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.114
RHEA:44380: a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.64
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
case <OC:Saccharomyces>
Subunit Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with COQ3.
else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces>
Subunit Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9).
else
Subunit Component of a multi-subunit COQ enzyme complex.
end case
Subcellular location Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.

Keywords [?]

Membrane
Methyltransferase
Mitochondrion
Mitochondrion inner membrane
S-adenosyl-L-methionine
Transferase
Ubiquinone biosynthesis

Gene Ontology [?]

GO:0031314; Cellular component: extrinsic component of mitochondrial inner membrane.
case <OC:Saccharomycotina>
GO:0061543; Molecular function: 3-demethylubiquinol-6 3-O-methyltransferase activity.
GO:0004395; Molecular function: hexaprenyldihydroxybenzoate methyltransferase activity.
else case <OC:Hominidae> or <OC:Schizosaccharomycetes>
GO:0044596; Molecular function: 3-demethylubiquinol-10 3-O-methyltransferase activity.
GO:0044595; Molecular function: decaprenyldihydroxybenzoate methyltransferase activity.
else case <OC:Arabidopsis>
GO:0008689; Molecular function: 3-demethylubiquinone-9 3-O-methyltransferase activity.
GO:0010420; Molecular function: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity.
else
GO:0061542; Molecular function: 3-demethylubiquinol-n 3-O-methyltransferase activity.
GO:0010420; Molecular function: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity.
end case
GO:0006744; Biological process: ubiquinone biosynthetic process.

Cross-references [?]

Pfam PF08241; Methyltransf_11; 0-1;
PF13847; Methyltransf_31; 0-1;
TIGRFAMs TIGR01983; UbiG; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

From: COQ3_YEAST (P27680)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     68     68       S-adenosyl-L-methionine     R  
BINDING     130     130       S-adenosyl-L-methionine; via carbonyl oxygen     G  
BINDING     153     153       S-adenosyl-L-methionine     D  
BINDING     196     196       S-adenosyl-L-methionine; via carbonyl oxygen        

Additional information [?]

Size range 232-371 amino acids
Related rules None
Fusion None


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