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HAMAP rule MF_03190

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General rule information [?]

Accession MF_03190
Dates 11-MAR-2015 (Created)
1-JUN-2023 (Last updated, Version 14)
Name UbiG_COQ3_euk
Scope(s) Eukaryota
Template(s) P27680 (COQ3_YEAST); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00472 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier COQ3
Protein name RecName: Full=Ubiquinone biosynthesis O-methyltransferase, mitochondrial;
AltName: Full=3-demethylubiquinol 3-O-methyltransferase;
AltName: Full=Polyprenyldihydroxybenzoate methyltransferase;
case <OC:Saccharomycotina>
Protein name + AltName: Full=3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase;
                 Short=DHHB methyltransferase;
AltName: Full=3-demethylubiquinone-6 3-O-methyltransferase;
AltName: Full=Hexaprenyldihydroxybenzoate methyltransferase;
end case
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
Gene name Name=COQ3;
else case <OC:Drosophilidae>
Gene name Name=Coq3;
else case <OC:Insecta> or <OC:Dictyostelia>
Gene name Name=coq3;
else case <OC:Caenorhabditis>
Gene name Name=coq-3;
end case

Comments [?]

FUNCTIONO-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
CATALYTIC ACTIVITY Reaction=3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L- methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44452, Rhea:RHEA- COMP:10930, Rhea:RHEA-COMP:10931, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64694, ChEBI:CHEBI:84443; EC=;
CATALYTIC ACTIVITY Reaction=a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44380, Rhea:RHEA- COMP:9566, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:15378, ChEBI:CHEBI:17976, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84422; EC=;
PATHWAYCofactor biosynthesis; ubiquinone biosynthesis.
case <OC:Saccharomyces>
SUBUNITComponent of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with COQ3.
else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces>
SUBUNITComponent of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9).
SUBUNITComponent of a multi-subunit COQ enzyme complex.
end case
SUBCELLULAR LOCATIONMitochondrion inner membrane; Peripheral membrane protein; Matrix side.
case not <AnyFeature:TransitM>
MISCELLANEOUSThis protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.

Keywords [?]

Gene Ontology [?]

GO:0031314; Cellular component:extrinsic component of mitochondrial inner membrane
case <OCellular component:Saccharomycotina>
GO:0061543; Molecular function:3-demethylubiquinol-6 3-O-methyltransferase activity
GO:0004395; Molecular function:hexaprenyldihydroxybenzoate methyltransferase activity
else case <OCellular component:Hominidae> or <OC:Schizosaccharomycetes>
GO:0044596; Molecular function:3-demethylubiquinol-10 3-O-methyltransferase activity
GO:0044595; Molecular function:decaprenyldihydroxybenzoate methyltransferase activity
else case <OCellular component:Arabidopsis>
GO:0008689; Molecular function:3-demethylubiquinone-9 3-O-methyltransferase activity
GO:0010420; Molecular function:3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0061542; Molecular function:3-demethylubiquinol-n 3-O-methyltransferase activity
GO:0010420; Molecular function:3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
end case
GO:0006744; Biological process:ubiquinone biosynthetic process

Cross-references [?]

Pfam PF08241; Methyltransf_11; 0-1;
Pfam PF13847; Methyltransf_31; 0-1;
NCBIfam TIGR01983; UbiG; 1;
General TransitM; -; 0-1;

Features [?]

From: COQ3_YEAST (P27680)
Key From To Description Tag Condition FTGroup
BINDING 68 68 /ligand="S-adenosyl-L-methionine"
BINDING 130 130 /ligand="S-adenosyl-L-methionine"
BINDING 153 153 /ligand="S-adenosyl-L-methionine"
BINDING 196 196 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 232-371 amino acids
Related rules None
Fusion Nter: None Cter: None

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