 |
|
Annotation rule MF_03190 |
General rule information
[?]
Accession |
MF_03190 |
Dates |
11-MAR-2015 (Created) 24-JAN-2020 (Last updated, Version 11) |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
|
Full=Ubiquinone biosynthesis O-methyltransferase, mitochondrial;
|
AltName:
|
Full=3-demethylubiquinol 3-O-methyltransferase;
|
|
EC 2.1.1.64;
|
AltName:
|
Full=Polyprenyldihydroxybenzoate methyltransferase;
|
|
EC 2.1.1.114;
|
|
case <OC:Saccharomycotina>
Protein name |
|
|
Full=3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase;
|
|
|
Short=DHHB methyltransferase;
|
|
|
Short=DHHB-MT;
|
|
|
Short=DHHB-MTase;
|
|
AltName:
|
Full=3-demethylubiquinone-6 3-O-methyltransferase;
|
|
AltName:
|
Full=Hexaprenyldihydroxybenzoate methyltransferase;
|
|
end case
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
else case <OC:Drosophilidae>
else case <OC:Insecta> or <OC:Dictyostelia>
else case <OC:Caenorhabditis>
end case
Function |
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. |
Catalytic activity |
RHEA:44452: 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.114
|
|
RHEA:44380: a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.64
|
Pathway |
Cofactor biosynthesis; ubiquinone biosynthesis. |
case <OC:Saccharomyces>
Subunit |
Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with COQ3. |
else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces>
Subunit |
Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). |
else
Subunit |
Component of a multi-subunit COQ enzyme complex. |
end case
Subcellular location |
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
case not <AnyFeature:TransitM>
Miscellaneous |
This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. |
GO:0031314; Cellular component: extrinsic component of mitochondrial inner membrane.
case <OC:Saccharomycotina>
GO:0061543; Molecular function: 3-demethylubiquinol-6 3-O-methyltransferase activity.
GO:0004395; Molecular function: hexaprenyldihydroxybenzoate methyltransferase activity.
else case <OC:Hominidae> or <OC:Schizosaccharomycetes>
GO:0044596; Molecular function: 3-demethylubiquinol-10 3-O-methyltransferase activity.
GO:0044595; Molecular function: decaprenyldihydroxybenzoate methyltransferase activity.
else case <OC:Arabidopsis>
GO:0008689; Molecular function: 3-demethylubiquinone-9 3-O-methyltransferase activity.
GO:0010420; Molecular function: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity.
else
GO:0061542; Molecular function: 3-demethylubiquinol-n 3-O-methyltransferase activity.
GO:0010420; Molecular function: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity.
end case
GO:0006744; Biological process: ubiquinone biosynthetic process.
General |
TransitM; -; 0-1; trigger=yes; |
From: COQ3_YEAST (P27680) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
BINDING
|
|
68
|
|
68
|
|
S-adenosyl-L-methionine
|
|
|
|
R
|
|
|
BINDING
|
|
130
|
|
130
|
|
S-adenosyl-L-methionine; via carbonyl oxygen
|
|
|
|
G
|
|
|
BINDING
|
|
153
|
|
153
|
|
S-adenosyl-L-methionine
|
|
|
|
D
|
|
|
BINDING
|
|
196
|
|
196
|
|
S-adenosyl-L-methionine; via carbonyl oxygen
|
|
|
|
|
|
|
Additional information
[?]
Size range |
232-371 amino acids |
Related rules |
None |
Fusion |
None |