HAMAP rule MF_03190
General rule information
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| Accession | MF_03190 |
| Dates | 11-MAR-2015 (Created)
1-JUN-2023 (Last updated, Version 14) |
| Name | UbiG_COQ3_euk |
| Scope(s) |
Eukaryota |
| Template(s) | P27680 (COQ3_YEAST); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_00472 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | COQ3 |
| Protein name | RecName: Full=Ubiquinone biosynthesis O-methyltransferase, mitochondrial; AltName: Full=3-demethylubiquinol 3-O-methyltransferase; EC=2.1.1.64; AltName: Full=Polyprenyldihydroxybenzoate methyltransferase; EC=2.1.1.114; |
| case <OC:Saccharomycotina> | |
| Protein name | + AltName: Full=3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; Short=DHHB methyltransferase; Short=DHHB-MT; Short=DHHB-MTase; AltName: Full=3-demethylubiquinone-6 3-O-methyltransferase; AltName: Full=Hexaprenyldihydroxybenzoate methyltransferase; |
| end case | |
| case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae> | |
| Gene name | Name=COQ3; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=Coq3; |
| else case <OC:Insecta> or <OC:Dictyostelia> | |
| Gene name | Name=coq3; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=coq-3; |
| end case | |
Comments
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| FUNCTION | O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. |
| CATALYTIC ACTIVITY | Reaction=3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L- methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44452, Rhea:RHEA- COMP:10930, Rhea:RHEA-COMP:10931, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64694, ChEBI:CHEBI:84443; EC=2.1.1.114; |
| CATALYTIC ACTIVITY | Reaction=a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44380, Rhea:RHEA- COMP:9566, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:15378, ChEBI:CHEBI:17976, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84422; EC=2.1.1.64; |
| PATHWAY | Cofactor biosynthesis; ubiquinone biosynthesis. |
| case <OC:Saccharomyces> | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with COQ3. |
| else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces> | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). |
| else | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex. |
| end case | |
| SUBCELLULAR LOCATION | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| case not <AnyFeature:TransitM> | |
| MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
| end case | |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. |
Keywords
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| Membrane |
| Methyltransferase |
| Mitochondrion |
| Mitochondrion inner membrane |
| S-adenosyl-L-methionine |
| Transferase |
| Ubiquinone biosynthesis |
Gene Ontology
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| GO:0031314; Cellular component:extrinsic component of mitochondrial inner membrane | |
| case <OCellular component:Saccharomycotina> | |
| GO:0061543; Molecular function:3-demethylubiquinol-6 3-O-methyltransferase activity | |
| GO:0004395; Molecular function:hexaprenyldihydroxybenzoate methyltransferase activity | |
| else case <OCellular component:Hominidae> or <OC:Schizosaccharomycetes> | |
| GO:0044596; Molecular function:3-demethylubiquinol-10 3-O-methyltransferase activity | |
| GO:0044595; Molecular function:decaprenyldihydroxybenzoate methyltransferase activity | |
| else case <OCellular component:Arabidopsis> | |
| GO:0008689; Molecular function:3-demethylubiquinone-9 3-O-methyltransferase activity | |
| GO:0010420; Molecular function:3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0061542; Molecular function:3-demethylubiquinol-n 3-O-methyltransferase activity | |
| GO:0010420; Molecular function:3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity | |
| end case | |
| GO:0006744; Biological process:ubiquinone biosynthetic process | |
Cross-references
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| Pfam | PF08241; Methyltransf_11; 0-1; |
| Pfam | PF13847; Methyltransf_31; 0-1; |
| NCBIfam | TIGR01983; UbiG; 1; |
| General | TransitM; -; 0-1; |
Features
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| From: COQ3_YEAST (P27680) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 68 | 68 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
R | ||||||||
| BINDING | 130 | 130 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
| BINDING | 153 | 153 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 196 | 196 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
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Additional information
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| Size range | 232-371 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |