HAMAP rule MF_03191
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03191 |
| Accession | MF_03191 |
| Dates | 18-MAR-2015 (Created)
10-OCT-2024 (Last updated, Version 14) |
| Name | MenG_UbiE_methyltr_euk |
| Scope(s) |
Eukaryota |
| Template(s) | P49017 (COQ5_YEAST); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01813 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | COQ5 |
| Protein name | RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; EC=2.1.1.201; AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5; |
| case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae> | |
| Gene name | Name=COQ5; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=Coq5; |
| else case <OC:Insecta> or <OC:Dictyostelia> | |
| Gene name | Name=coq5; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=coq-5; |
| end case | |
Comments
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| FUNCTION | Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). |
| CATALYTIC ACTIVITY | Reaction=a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S- adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans- polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201; |
| PATHWAY | Cofactor biosynthesis; ubiquinone biosynthesis. |
| case <OC:Saccharomyces> | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with COQ3. |
| else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces> | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). |
| else | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex. |
| end case | |
| SUBCELLULAR LOCATION | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| case not <AnyFeature:TransitM> | |
| MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
| end case | |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family. |
Keywords
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| Membrane |
| Methyltransferase |
| Mitochondrion |
| Mitochondrion inner membrane |
| S-adenosyl-L-methionine |
| Transferase |
| Ubiquinone biosynthesis |
Gene Ontology
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| GO:0031314; Cellular component:extrinsic component of mitochondrial inner membrane |
| GO:0008425; Molecular function:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity |
| GO:0006744; Biological process:ubiquinone biosynthetic process |
Cross-references
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| PROSITE | PS51608; SAM_MT_UBIE; 1; |
| PROSITE | PS01183; UBIE_1; 1; |
| PROSITE | PS01184; UBIE_2; 1; |
| Pfam | PF01209; Ubie_methyltran; 1; |
| NCBIfam | TIGR01934; MenG_MenH_UbiE; 1; |
| NCBIfam | TIGR02752; MenG_heptapren; 1; |
| General | TransitM; -; 0-1; |
Features
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| From: COQ5_YEAST (P49017) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 179 | 180 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ND]-x | ||||||||
| BINDING | 122 | 122 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ST] | ||||||||
| BINDING | 148 | 148 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 197 | 197 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
S | ||||||||
Additional information
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| Size range | 218-330 amino acids |
| Related rules |
MF_03192 MF_01982 |
| Fusion | Nter: None Cter: None |