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HAMAP rule MF_03191

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General rule information [?]

Accession MF_03191
Dates 18-MAR-2015 (Created)
1-JUN-2023 (Last updated, Version 11)
Name MenG_UbiE_methyltr_euk
Scope(s) Eukaryota
Template(s) P49017 (COQ5_YEAST); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_01813 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier COQ5
Protein name RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial;
AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5;
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
Gene name Name=COQ5;
else case <OC:Drosophilidae>
Gene name Name=Coq5;
else case <OC:Insecta> or <OC:Dictyostelia>
Gene name Name=coq5;
else case <OC:Caenorhabditis>
Gene name Name=coq-5;
end case

Comments [?]

FUNCTIONMethyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).
CATALYTIC ACTIVITY Reaction=a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S- adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl- 1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=;
PATHWAYCofactor biosynthesis; ubiquinone biosynthesis.
case <OC:Saccharomyces>
SUBUNITComponent of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with COQ3.
else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces>
SUBUNITComponent of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9).
SUBUNITComponent of a multi-subunit COQ enzyme complex.
end case
SUBCELLULAR LOCATIONMitochondrion inner membrane; Peripheral membrane protein; Matrix side.
case not <AnyFeature:TransitM>
MISCELLANEOUSThis protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Keywords [?]

Gene Ontology [?]

GO:0031314; Cellular component:extrinsic component of mitochondrial inner membrane
case <OCellular component:Saccharomycotina>
GO:0043334; Molecular function:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
else case <OCellular component:Hominidae> or <OC:Schizosaccharomycetes>
GO:0043430; Molecular function:2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
else case <OCellular component:Arabidopsis>
GO:0043429; Molecular function:2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0008425; Molecular function:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
end case
GO:0006744; Biological process:ubiquinone biosynthetic process

Cross-references [?]

PROSITE PS01183; UBIE_1; 1;
PROSITE PS01184; UBIE_2; 1;
Pfam PF01209; Ubie_methyltran; 1;
NCBIfam TIGR01934; MenG_MenH_UbiE; 1;
NCBIfam TIGR02752; MenG_heptapren; 1;
General TransitM; -; 0-1;

Features [?]

From: COQ5_YEAST (P49017)
Key From To Description Tag Condition FTGroup
BINDING 179 180 /ligand="S-adenosyl-L-methionine"
BINDING 122 122 /ligand="S-adenosyl-L-methionine"
BINDING 148 148 /ligand="S-adenosyl-L-methionine"
BINDING 197 197 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 218-330 amino acids
Related rules MF_03192
Fusion Nter: None Cter: None

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