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Annotation rule MF_03191
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General rule information [?]

Accession MF_03191
Dates 18-MAR-2015 (Created)
10-DEC-2019 (Last updated, Version 7)
Name MenG_UbiE_methyltr_euk
Scope
Eukaryota
Template P49017 (COQ5_YEAST)
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COQ5
Protein name
RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial;
EC 2.1.1.201;
AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5;
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
Gene name
COQ5
else case <OC:Drosophilidae>
Gene name
Coq5
else case <OC:Insecta> or <OC:Dictyostelia>
Gene name
coq5
else case <OC:Caenorhabditis>
Gene name
coq-5
end case

Comments [?]

Function Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Catalytic activity RHEA:28286: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.201
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
case <OC:Saccharomyces>
Subunit Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with COQ3.
else case <OC:Vertebrata> or <OC:Fungi> and not <OC:Saccharomyces>
Subunit Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9).
else
Subunit Component of a multi-subunit COQ enzyme complex.
end case
Subcellular location Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Keywords [?]


Gene Ontology [?]

GO:0031314; Cellular component: extrinsic component of mitochondrial inner membrane.
case <OC:Saccharomycotina>
GO:0043334; Molecular function: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity.
else case <OC:Hominidae> or <OC:Schizosaccharomycetes>
GO:0043430; Molecular function: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity.
else case <OC:Arabidopsis>
GO:0043429; Molecular function: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity.
else
GO:0008425; Molecular function: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity.
end case
GO:0006744; Biological process: ubiquinone biosynthetic process.

Cross-references [?]

PROSITE PS51608; SAM_MT_UBIE; 1;
PS01183; UBIE_1; 1;
PS01184; UBIE_2; 1;
Pfam PF01209; Ubie_methyltran; 1;
TIGRFAMs TIGR01934; MenG_MenH_UbiE; 1;
TIGR02752; MenG_heptapren; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

From: COQ5_YEAST (P49017)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     179     180       S-adenosyl-L-methionine binding     [ND]-x  
BINDING     122     122       S-adenosyl-L-methionine     [ST]  
BINDING     148     148       S-adenosyl-L-methionine     D  
BINDING     197     197       S-adenosyl-L-methionine     S  

Additional information [?]

Size range 218-330 amino acids
Related rules MF_03192 (MENG supersedes the current rule); MF_01982 (MENG supersedes the current rule)
Fusion None