HAMAP rule MF_03194
General rule information
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| Accession | MF_03194 |
| Dates | 27-MAR-2015 (Created)
19-NOV-2022 (Last updated, Version 9) |
| Name | DMQ_hydroxylase_COQ7 |
| Scope(s) |
Eukaryota |
| Template(s) | P41735 (COQ7_YEAST); Q9I5R6 (COQ7_PSEAE); P97478 (COQ7_MOUSE); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01658 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | COQ7 |
| Protein name | RecName: Full=5-demethoxyubiquinone hydroxylase, mitochondrial; Short=DMQ hydroxylase; EC=1.14.99.60; AltName: Full=Ubiquinone biosynthesis monooxygenase COQ7; |
| case <OC:Vertebrata> | |
| Protein name | + AltName: Full=Timing protein clk-1 homolog; |
| end case | |
| case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae> | |
| Gene name | Name=COQ7; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=Coq7; |
| else case <OC:Insecta> or <OC:Dictyostelia> | |
| Gene name | Name=coq7; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=clk-1; |
| end case | |
Comments
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| case <OC:Saccharomyces> | |
| FUNCTION | Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides. |
| else case <OC:Metazoa> | |
| FUNCTION | Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. |
| else | |
| FUNCTION | Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O; Xref=Rhea:RHEA:50908, Rhea:RHEA-COMP:10859, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:84167, ChEBI:CHEBI:84422; EC=1.14.99.60; |
| COFACTOR | Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.; |
| PATHWAY | Cofactor biosynthesis; ubiquinone biosynthesis. |
| case <OC:Vertebrata> | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with @gn(ADCK4) and @gn(COQ6). Interacts with @gn(COQ9). |
| else case <OC:Fungi> | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). |
| else | |
| SUBUNIT | Component of a multi-subunit COQ enzyme complex. |
| end case | |
| SUBCELLULAR LOCATION | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| case not <AnyFeature:TransitM> | |
| MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
| end case | |
| SIMILARITY | Belongs to the COQ7 family. |
Keywords
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| Iron |
| Membrane |
| Metal-binding |
| Mitochondrion |
| Mitochondrion inner membrane |
| Monooxygenase |
| Oxidoreductase |
| Ubiquinone biosynthesis |
Gene Ontology
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| GO:0031314; Cellular component:extrinsic component of mitochondrial inner membrane |
| GO:0016709; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0006744; Biological process:ubiquinone biosynthetic process |
Cross-references
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Features
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| From: COQ7_PSEAE (Q9I5R6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 64 | 64 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
E | ||||||||
| BINDING | 94 | 94 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
E | ||||||||
| BINDING | 94 | 94 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
E | ||||||||
| BINDING | 97 | 97 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
H | ||||||||
| BINDING | 146 | 146 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
E | ||||||||
| BINDING | 178 | 178 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1" |
E | ||||||||
| BINDING | 178 | 178 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
E | ||||||||
| BINDING | 181 | 181 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2" |
H | ||||||||
Additional information
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| Size range | 181-268 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |