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HAMAP rule MF_03194

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General rule information [?]

Accession MF_03194
Dates 27-MAR-2015 (Created)
19-NOV-2022 (Last updated, Version 9)
Name DMQ_hydroxylase_COQ7
Scope
Eukaryota
Templates P41735 (COQ7_YEAST); Q9I5R6 (COQ7_PSEAE); P97478 (COQ7_MOUSE): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COQ7
Protein name
RecName: Full=5-demethoxyubiquinone hydroxylase, mitochondrial;
Short=DMQ hydroxylase;
EC 1.14.99.60;
AltName: Full=Ubiquinone biosynthesis monooxygenase COQ7;
case <OC:Vertebrata>
Protein name
Full=Timing protein clk-1 homolog;
end case
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
Gene name
COQ7
else case <OC:Drosophilidae>
Gene name
Coq7
else case <OC:Insecta> or <OC:Dictyostelia>
Gene name
coq7
else case <OC:Caenorhabditis>
Gene name
clk-1
end case

Comments [?]

case <OC:Saccharomyces>
Function Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides.
else case <OC:Metazoa>
Function Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
else
Function Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
end case
Catalytic activity RHEA:50908: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O
EC 1.14.99.60
Cofactor Fe cation
Note: Binds 2 iron ions per subunit.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
case <OC:Vertebrata>
Subunit Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with @gn(ADCK4) and @gn(COQ6). Interacts with @gn(COQ9).
else case <OC:Fungi>
Subunit Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9).
else
Subunit Component of a multi-subunit COQ enzyme complex.
end case
Subcellular location Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the COQ7 family.

Keywords [?]

Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Monooxygenase
Oxidoreductase
Ubiquinone biosynthesis

Gene Ontology [?]

GO:0031314; Cellular component: extrinsic component of mitochondrial inner membrane.
GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.
GO:0006744; Biological process: ubiquinone biosynthetic process.

Cross-references [?]

Pfam PF03232; COQ7; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

From: COQ7_PSEAE (Q9I5R6)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     64     64       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     E  
BINDING     94     94       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     E  
BINDING     94     94       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     E  
BINDING     97     97       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     H  
BINDING     146     146       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     E  
BINDING     178     178       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     E  
BINDING     178     178       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     E  
BINDING     181     181       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     H  

Additional information [?]

Size range 181-268 amino acids
Related rules None
Fusion None


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