HAMAP rule MF_03194
General rule information
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Accession | MF_03194 |
Dates | 27-MAR-2015 (Created) 19-NOV-2022 (Last updated, Version 9) |
Name | DMQ_hydroxylase_COQ7 |
Scope | Eukaryota |
Templates | P41735 (COQ7_YEAST); Q9I5R6 (COQ7_PSEAE); P97478 (COQ7_MOUSE): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Vertebrata>
Protein name |
|
end case
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
Gene name |
|
else case <OC:Drosophilidae>
Gene name |
|
else case <OC:Insecta> or <OC:Dictyostelia>
Gene name |
|
else case <OC:Caenorhabditis>
Gene name |
|
end case
Comments
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case <OC:Saccharomyces>
Function | Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides. |
else case <OC:Metazoa>
Function | Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. |
else
Function | Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. |
end case
Catalytic activity | RHEA:50908: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O
EC 1.14.99.60 |
Cofactor | Fe cation Note: Binds 2 iron ions per subunit. |
Pathway | Cofactor biosynthesis; ubiquinone biosynthesis. |
case <OC:Vertebrata>
Subunit | Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with @gn(ADCK4) and @gn(COQ6). Interacts with @gn(COQ9). |
else case <OC:Fungi>
Subunit | Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). |
else
Subunit | Component of a multi-subunit COQ enzyme complex. |
end case
Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
case not <AnyFeature:TransitM>
Miscellaneous | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Similarity | Belongs to the COQ7 family. |
Keywords
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Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Monooxygenase
Oxidoreductase
Ubiquinone biosynthesis
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Monooxygenase
Oxidoreductase
Ubiquinone biosynthesis
Gene Ontology
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GO:0031314; Cellular component: extrinsic component of mitochondrial inner membrane.
GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.
GO:0006744; Biological process: ubiquinone biosynthetic process.
GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.
GO:0006744; Biological process: ubiquinone biosynthetic process.
Cross-references
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Pfam | PF03232; COQ7; 1; |
Computed features
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General | TransitM; -; 0-1; trigger=yes; |
Features
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From: COQ7_PSEAE (Q9I5R6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 64 | 64 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | E | ||||||||
BINDING | 94 | 94 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | E | ||||||||
BINDING | 94 | 94 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | E | ||||||||
BINDING | 97 | 97 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | H | ||||||||
BINDING | 146 | 146 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | E | ||||||||
BINDING | 178 | 178 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | E | ||||||||
BINDING | 178 | 178 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | E | ||||||||
BINDING | 181 | 181 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | H |
Additional information
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Size range | 181-268 amino acids |
Related rules | None |
Fusion | None |