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Annotation rule MF_03194 |
General rule information
[?]
Accession |
MF_03194 |
Dates |
27-MAR-2015 (Created) 26-MAR-2020 (Last updated, Version 7) |
Name |
DMQ_hydroxylase_COQ7 |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=5-demethoxyubiquinone hydroxylase, mitochondrial;
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Short=DMQ hydroxylase;
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EC 1.14.99.60;
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AltName:
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Full=Ubiquinone biosynthesis monooxygenase COQ7;
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case <OC:Vertebrata>
Protein name |
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Full=Timing protein clk-1 homolog;
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end case
case <OC:Vertebrata> or <OC:Fungi> or <OC:Viridiplantae>
else case <OC:Drosophilidae>
else case <OC:Insecta> or <OC:Dictyostelia>
else case <OC:Caenorhabditis>
end case
case <OC:Saccharomyces>
Function |
Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides. |
else case <OC:Metazoa>
Function |
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. |
else
Function |
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. |
end case
Catalytic activity |
RHEA:50908: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O
EC 1.14.99.60
|
Cofactor |
Fe cation Note: Binds 2 iron ions per subunit. |
Pathway |
Cofactor biosynthesis; ubiquinone biosynthesis. |
case <OC:Vertebrata>
Subunit |
Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). Interacts with @gn(ADCK4) and @gn(COQ6). Interacts with @gn(COQ9). |
else case <OC:Fungi>
Subunit |
Component of a multi-subunit COQ enzyme complex, composed of at least @gn(COQ3), @gn(COQ4), @gn(COQ5), @gn(COQ6), @gn(COQ7) and @gn(COQ9). |
else
Subunit |
Component of a multi-subunit COQ enzyme complex. |
end case
Subcellular location |
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
case not <AnyFeature:TransitM>
Miscellaneous |
This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Similarity |
Belongs to the COQ7 family. |
GO:0031314; Cellular component: extrinsic component of mitochondrial inner membrane.
GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.
GO:0006744; Biological process: ubiquinone biosynthetic process.
General |
TransitM; -; 0-1; trigger=yes; |
From: COQ7_PSEAE (Q9I5R6) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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METAL
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64
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64
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Iron 1
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E
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METAL
|
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94
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94
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Iron 1
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E
|
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METAL
|
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94
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94
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Iron 2
|
|
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E
|
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METAL
|
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97
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97
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Iron 1
|
|
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H
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METAL
|
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146
|
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146
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Iron 2
|
|
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E
|
|
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METAL
|
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178
|
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178
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Iron 1
|
|
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E
|
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METAL
|
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178
|
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178
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Iron 2
|
|
|
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E
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METAL
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181
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181
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Iron 2
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H
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Additional information
[?]
Size range |
181-268 amino acids |
Related rules |
None |
Fusion |
None |