HAMAP rule MF_03199
General rule information
[?]
| Accession | MF_03199 |
| Dates | 29-OCT-2015 (Created)
20-NOV-2019 (Last updated, Version 6) |
| Name | DHHC_PAT_PFA4 |
| Scope(s) |
Eukaryota Fungi |
| Template(s) | Q12006 (PFA4_YEAST); J9VJ99 (PFA4_CRYNH); [ Recover all ] |
| Triggered by |
HAMAP; MF_03199 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | PFA4 |
| Protein name | RecName: Full=Palmitoyltransferase EC=2.3.1.225; AltName: Full=Protein S-acyltransferase; Short=PAT; AltName: Full=Protein fatty acyltransferase 4; |
| Gene name | Name=PFA4; |
Comments
[?]
| FUNCTION | Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. |
| CATALYTIC ACTIVITY | Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| DOMAIN | The DHHC domain is required for palmitoyltransferase activity. |
| SIMILARITY | Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily. |
Keywords
[?]
| Acyltransferase |
| Endoplasmic reticulum |
| Lipoprotein |
| Membrane |
| Palmitate |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
[?]
| GO:0005789; Cellular component:endoplasmic reticulum membrane |
| GO:0016409; Molecular function:palmitoyltransferase activity |
| GO:0019706; Molecular function:protein-cysteine S-palmitoyltransferase activity |
| GO:0018345; Biological process:protein palmitoylation |
Cross-references
[?]
| PROSITE | PS50216; DHHC; 1; |
| Pfam | PF01529; zf-DHHC; 1; |
| General | Transmembrane; -; 4; |
| ADD_TOPO_DOMAIN | Cytoplasmic; -; 3; |
| ADD_TOPO_DOMAIN | Lumenal; -; 2; |
Features
[?]
| From: PFA4_YEAST (Q12006) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 108 | 108 | /note="S-palmitoyl cysteine intermediate" | C | ||||||||
Additional information
[?]
| Size range | 342-486 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |