HAMAP rule MF_03199
General rule information
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Accession | MF_03199 |
Dates | 29-OCT-2015 (Created) 20-NOV-2019 (Last updated, Version 6) |
Name | DHHC_PAT_PFA4 |
Scope | Eukaryota; Fungi |
Templates | Q12006 (PFA4_YEAST); J9VJ99 (PFA4_CRYNH): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. |
Catalytic activity | RHEA:36683: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]
EC 2.3.1.225 |
Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Domain | The DHHC domain is required for palmitoyltransferase activity. |
Similarity | Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily. |
Keywords
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Acyltransferase
Endoplasmic reticulum
Lipoprotein
Membrane
Palmitate
Transferase
Transmembrane
Transmembrane helix
Endoplasmic reticulum
Lipoprotein
Membrane
Palmitate
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016409; Molecular function: palmitoyltransferase activity.
GO:0019706; Molecular function: protein-cysteine S-palmitoyltransferase activity.
GO:0018345; Biological process: protein palmitoylation.
GO:0016409; Molecular function: palmitoyltransferase activity.
GO:0019706; Molecular function: protein-cysteine S-palmitoyltransferase activity.
GO:0018345; Biological process: protein palmitoylation.
Cross-references
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Computed features
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General | Transmembrane; -; 4; trigger=yes; |
ADD_TOPO_DOMAIN | Cytoplasmic; -; 3; trigger=yes; |
Lumenal; -; 2; trigger=yes; |
Features
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From: PFA4_YEAST (Q12006) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 108 | 108 | S-palmitoyl cysteine intermediate | C |
Additional information
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Size range | 342-486 amino acids |
Related rules | None |
Fusion | None |