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Annotation rule MF_03199
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General rule information [?]

Accession MF_03199
Dates 29-OCT-2015 (Created)
20-NOV-2019 (Last updated, Version 6)
Name DHHC_PAT_PFA4
Scope
Eukaryota; Fungi
Templates Q12006 (PFA4_YEAST); J9VJ99 (PFA4_CRYNH): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PFA4
Protein name
RecName: Full=Palmitoyltransferase ;
EC 2.3.1.225;
AltName: Full=Protein S-acyltransferase;
Short=PAT;
AltName: Full=Protein fatty acyltransferase 4;
Gene name
PFA4

Comments [?]

Function Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
Catalytic activity RHEA:36683: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]
EC 2.3.1.225
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain The DHHC domain is required for palmitoyltransferase activity.
Similarity Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.

Keywords [?]

Acyltransferase
Endoplasmic reticulum
Lipoprotein
Membrane
Palmitate
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016409; Molecular function: palmitoyltransferase activity.
GO:0019706; Molecular function: protein-cysteine S-palmitoyltransferase activity.
GO:0018345; Biological process: protein palmitoylation.

Cross-references [?]

PROSITE PS50216; DHHC; 1; trigger=PRU00067;
Pfam PF01529; zf-DHHC; 1;

Computed features [?]

General Transmembrane; -; 4; trigger=yes;
ADD_TOPO_DOMAIN Cytoplasmic; -; 3; trigger=yes;
Lumenal; -; 2; trigger=yes;

Features [?]

From: PFA4_YEAST (Q12006)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     108     108       S-palmitoyl cysteine intermediate     C  

Additional information [?]

Size range 342-486 amino acids
Related rules None
Fusion None


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