HAMAP rule MF_03199

Accession	MF_03199
Dates	29-OCT-2015 (Created) 20-NOV-2019 (Last updated, Version 6)

Name	DHHC_PAT_PFA4

Scope

Eukaryota; Fungi

Templates

Q12006 (PFA4_YEAST); J9VJ99 (PFA4_CRYNH): [Recover all]

Triggered by

HAMAP; MF_03199 (Get profile general information and statistics)

Identifier

PFA4

Protein name

RecName: Full=Palmitoyltransferase ; EC 2.3.1.225; AltName: Full=Protein S-acyltransferase; Short=PAT; AltName: Full=Protein fatty acyltransferase 4;

Gene name

PFA4

Function	Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
Catalytic activity	RHEA:36683: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] EC 2.3.1.225
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain	The DHHC domain is required for palmitoyltransferase activity.
Similarity	Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.

Acyltransferase
Endoplasmic reticulum
Lipoprotein
Membrane
Palmitate
Transferase
Transmembrane
Transmembrane helix

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016409; Molecular function: palmitoyltransferase activity.
GO:0019706; Molecular function: protein-cysteine S-palmitoyltransferase activity.
GO:0018345; Biological process: protein palmitoylation.

PROSITE	PS50216; DHHC; 1; trigger=PRU00067;
Pfam	PF01529; zf-DHHC; 1;

General	Transmembrane; -; 4; trigger=yes;
ADD_TOPO_DOMAIN	Cytoplasmic; -; 3; trigger=yes;
	Lumenal; -; 2; trigger=yes;

From: PFA4_YEAST (Q12006)

Key

From

To

Description

Tag

Condition

FTGroup

ACT_SITE

108

108

S-palmitoyl cysteine intermediate

C

Size range	342-486 amino acids
Related rules	None
Fusion	None

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