HAMAP rule MF_03199
General rule information
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| Accession | MF_03199 |
| Dates | 29-OCT-2015 (Created)
3-SEP-2024 (Last updated, Version 7) |
| Name | DHHC_PAT_PFA4 |
| Scope(s) |
Eukaryota Fungi |
| Template(s) | Q12006 (PFA4_YEAST); J9VJ99 (PFA4_CRYNH); [ Recover all ] |
| Triggered by |
HAMAP; MF_03199 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PFA4 |
| Protein name | RecName: Full=Palmitoyltransferase EC=2.3.1.225; AltName: Full=Protein S-acyltransferase; Short=PAT; AltName: Full=Protein fatty acyltransferase 4; |
| Gene name | Name=PFA4; |
Comments
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| FUNCTION | Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. |
| CATALYTIC ACTIVITY | Reaction=L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L- cysteinyl-[protein] + CoA; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=2.3.1.225; |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| DOMAIN | The DHHC domain is required for palmitoyltransferase activity. |
| SIMILARITY | Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily. |
Keywords
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| Acyltransferase |
| Endoplasmic reticulum |
| Lipoprotein |
| Membrane |
| Palmitate |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0005789; Cellular component:endoplasmic reticulum membrane |
| GO:0016409; Molecular function:palmitoyltransferase activity |
| GO:0019706; Molecular function:protein-cysteine S-palmitoyltransferase activity |
| GO:0018345; Biological process:protein palmitoylation |
Cross-references
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| PROSITE | PS50216; DHHC; 1; |
| Pfam | PF01529; zf-DHHC; 1; |
| General | Transmembrane; -; 4; |
| ADD_TOPO_DOMAIN | Cytoplasmic; -; 3; |
| ADD_TOPO_DOMAIN | Lumenal; -; 2; |
Features
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| From: PFA4_YEAST (Q12006) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 108 | 108 | /note="S-palmitoyl cysteine intermediate" | C | ||||||||
Additional information
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| Size range | 342-486 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |