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HAMAP rule MF_03199

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General rule information [?]

Accession MF_03199
Dates 29-OCT-2015 (Created)
20-NOV-2019 (Last updated, Version 6)
Scope(s) Eukaryota
Template(s) Q12006 (PFA4_YEAST); J9VJ99 (PFA4_CRYNH); [ Recover all ]
Triggered by HAMAP; MF_03199 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PFA4
Protein name RecName: Full=Palmitoyltransferase ;
AltName: Full=Protein S-acyltransferase;
AltName: Full=Protein fatty acyltransferase 4;
Gene name Name=PFA4;

Comments [?]

FUNCTIONMediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
CATALYTIC ACTIVITY Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S- hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA- COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151; EC=;
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein.
DOMAINThe DHHC domain is required for palmitoyltransferase activity.
SIMILARITYBelongs to the DHHC palmitoyltransferase family. PFA4 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0016409; Molecular function:palmitoyltransferase activity
GO:0019706; Molecular function:protein-cysteine S-palmitoyltransferase activity
GO:0018345; Biological process:protein palmitoylation

Cross-references [?]

Pfam PF01529; zf-DHHC; 1;
General Transmembrane; -; 4;
ADD_TOPO_DOMAIN Cytoplasmic; -; 3;
ADD_TOPO_DOMAIN Lumenal; -; 2;

Features [?]

From: PFA4_YEAST (Q12006)
Key From To Description Tag Condition FTGroup
ACT_SITE 108 108 /note="S-palmitoyl cysteine intermediate" C

Additional information [?]

Size range 342-486 amino acids
Related rules None
Fusion Nter: None Cter: None

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