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Annotation rule MF_03199 |
Accession | MF_03199 |
Dates | 29-OCT-2015 (Created) 20-NOV-2019 (Last updated, Version 6) |
Name | DHHC_PAT_PFA4 |
Scope | Eukaryota; Fungi |
Templates | Q12006 (PFA4_YEAST); J9VJ99 (PFA4_CRYNH): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. |
Catalytic activity | RHEA:36683: hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]
EC 2.3.1.225 |
Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Domain | The DHHC domain is required for palmitoyltransferase activity. |
Similarity | Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily. |
General | Transmembrane; -; 4; trigger=yes; |
ADD_TOPO_DOMAIN | Cytoplasmic; -; 3; trigger=yes; |
Lumenal; -; 2; trigger=yes; |
From: PFA4_YEAST (Q12006) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 108 | 108 | S-palmitoyl cysteine intermediate | C |
Size range | 342-486 amino acids |
Related rules | None |
Fusion | None |