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Annotation rule MF_03201
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General rule information [?]

Accession MF_03201
Dates 16-DEC-2013 (Created)
20-NOV-2019 (Last updated, Version 13)
Name VLCF_elongase_1
Scope
Eukaryota; Vertebrata
Templates Q9BW60 (ELOV1_HUMAN); Q9JLJ5 (ELOV1_MOUSE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ELOV1
Protein name
RecName: Full=Elongation of very long chain fatty acids protein 1;
EC 2.3.1.199;
AltName: Full=3-keto acyl-CoA synthase ;
AltName: Full=ELOVL fatty acid elongase 1;
Short=ELOVL FA elongase 1;
AltName: Full=Very long chain 3-ketoacyl-CoA synthase 1;
AltName: Full=Very long chain 3-oxoacyl-CoA synthase 1;
Gene name
ELOVL1

Comments [?]

case <OC:Mammalia>
Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits @gn(RPE65) via production of VLCFAs.
else
Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
end case
Catalytic activity RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
EC 2.3.1.199
case <OC:Mammalia>
Subunit Interacts with @gn(LASS2), @gn(TECR) and @gn(HSD17B12).
end case
Pathway Lipid metabolism; fatty acid biosynthesis.
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
case <FTTag:ERmotif>
Domain The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
end case
Similarity Belongs to the ELO family. ELOVL1 subfamily.

Keywords [?]

Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0019367; Biological process: fatty acid elongation, saturated fatty acid.
GO:0034625; Biological process: fatty acid elongation, monounsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.

Cross-references [?]

PROSITE PS01188; ELO; 1;
Pfam PF01151; ELO; 1;

Computed features [?]

General Transmembrane; -; 7; trigger=yes;

Features [?]

From: ELOV1_HUMAN (Q9BW60)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     Cter-4     Cter       Di-lysine motif   ERmotif   K-x-K-x(2)>  

Additional information [?]

Size range 276-368 amino acids
Related rules MF_03204 (ELOV4); MF_03207 (ELOV7)
Fusion None


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