HAMAP rule MF_03201

General rule information [?]

Accession	MF_03201
Dates	16-DEC-2013 (Created) 29-SEP-2022 (Last updated, Version 14)
Name	VLCF_elongase_1
Scope(s)	Eukaryota Vertebrata
Template(s)	Q9BW60 (ELOV1_HUMAN); Q9JLJ5 (ELOV1_MOUSE); [ Recover all ]
Triggered by	HAMAP; MF_03201 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ELOV1
Protein name	RecName: Full=Elongation of very long chain fatty acids protein 1; EC=2.3.1.199; AltName: Full=3-keto acyl-CoA synthase ; AltName: Full=ELOVL fatty acid elongase 1; Short=ELOVL FA elongase 1; AltName: Full=Very long chain 3-ketoacyl-CoA synthase 1; AltName: Full=Very long chain 3-oxoacyl-CoA synthase 1;
Gene name	Name=ELOVL1;

Comments [?]

case <OC:Mammalia>
FUNCTION	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits @gn(RPE65) via production of VLCFAs.
else
FUNCTION	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
end case
CATALYTIC ACTIVITY	Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199;
case <OC:Mammalia>
SUBUNIT	Interacts with @gn(LASS2), @gn(TECR) and @gn(HSD17B12).
end case
PATHWAY	Lipid metabolism; fatty acid biosynthesis.
SUBCELLULAR LOCATION	Endoplasmic reticulum membrane; Multi-pass membrane protein.
case <FTTag:ERmotif>
DOMAIN	The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
end case
SIMILARITY	Belongs to the ELO family. ELOVL1 subfamily.

Keywords [?]

Endoplasmic reticulum

Fatty acid biosynthesis

Fatty acid metabolism

Lipid biosynthesis

Lipid metabolism

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane

GO:0016020; Cellular component:membrane

GO:0009922; Molecular function:fatty acid elongase activity

GO:0006636; Biological process:unsaturated fatty acid biosynthetic process

GO:0019367; Biological process:fatty acid elongation, saturated fatty acid

GO:0034625; Biological process:fatty acid elongation, monounsaturated fatty acid

GO:0035338; Biological process:long-chain fatty-acyl-CoA biosynthetic process

GO:0042761; Biological process:very long-chain fatty acid biosynthetic process

Cross-references [?]

PROSITE	PS01188; ELO; 1;
Pfam	PF01151; ELO; 1;
General	Transmembrane; -; 7;

Features [?]

From: ELOV1_HUMAN (Q9BW60)

Key

From

To

Description

Tag

Condition

FTGroup

MOTIF

Cter-4

Cter

/note="Di-lysine motif"

ERmotif

K-x-K-x(2)>

Additional information [?]

Size range	276-368 amino acids
Related rules	MF_03204 MF_03207
Fusion	Nter: None Cter: None

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