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HAMAP rule MF_03202

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General rule information [?]

Accession MF_03202
Dates 16-DEC-2013 (Created)
29-SEP-2022 (Last updated, Version 12)
Name VLCF_elongase_2
Scope
Eukaryota; Vertebrata
Templates Q9NXB9 (ELOV2_HUMAN); Q9JLJ4 (ELOV2_MOUSE); D4A612 (ELOV2_RAT): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ELOV2
Protein name
RecName: Full=Elongation of very long chain fatty acids protein 2;
EC 2.3.1.199;
AltName: Full=3-keto acyl-CoA synthase ;
AltName: Full=ELOVL fatty acid elongase 2;
Short=ELOVL FA elongase 2;
AltName: Full=Very long chain 3-ketoacyl-CoA synthase 2;
AltName: Full=Very long chain 3-oxoacyl-CoA synthase 2;
Gene name
ELOVL2

Comments [?]

Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalytic activity RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
EC 2.3.1.199
Pathway Lipid metabolism; polyunsaturated fatty acid biosynthesis.
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
case <FTTag:ERmotif>
Domain The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
end case
Similarity Belongs to the ELO family. ELOVL2 subfamily.

Keywords [?]

Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.

Cross-references [?]

PROSITE PS01188; ELO; 1;
Pfam PF01151; ELO; 1;

Computed features [?]

General Transmembrane; -; 7; trigger=yes;

Features [?]

From: ELOV2_HUMAN (Q9NXB9)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     Cter-3     Cter       Di-lysine motif   ERmotif   K-K-x(2)>  

Additional information [?]

Size range 257-343 amino acids
Related rules MF_03205 (ELOV5)
Fusion None


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