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HAMAP rule MF_03202

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General rule information [?]

Accession MF_03202
Dates 16-DEC-2013 (Created)
29-SEP-2022 (Last updated, Version 12)
Name VLCF_elongase_2
Scope(s) Eukaryota
Template(s) Q9NXB9 (ELOV2_HUMAN); Q9JLJ4 (ELOV2_MOUSE); D4A612 (ELOV2_RAT); [ Recover all ]
Triggered by HAMAP; MF_03202 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ELOV2
Protein name RecName: Full=Elongation of very long chain fatty acids protein 2;
AltName: Full=3-keto acyl-CoA synthase ;
AltName: Full=ELOVL fatty acid elongase 2;
                 Short=ELOVL FA elongase 2;
AltName: Full=Very long chain 3-ketoacyl-CoA synthase 2;
AltName: Full=Very long chain 3-oxoacyl-CoA synthase 2;
Gene name Name=ELOVL2;

Comments [?]

FUNCTIONCatalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
CATALYTIC ACTIVITY Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=;
PATHWAYLipid metabolism; polyunsaturated fatty acid biosynthesis.
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein.
case <FTTag:ERmotif>
DOMAINThe C-terminal di-lysine motif may confer endoplasmic reticulum localization.
end case
SIMILARITYBelongs to the ELO family. ELOVL2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0016020; Cellular component:membrane
GO:0009922; Molecular function:fatty acid elongase activity
GO:0034626; Biological process:fatty acid elongation, polyunsaturated fatty acid
GO:0042761; Biological process:very long-chain fatty acid biosynthetic process

Cross-references [?]

PROSITE PS01188; ELO; 1;
Pfam PF01151; ELO; 1;
General Transmembrane; -; 7;

Features [?]

Key From To Description Tag Condition FTGroup
MOTIF Cter-3 Cter /note="Di-lysine motif" ERmotif K-K-x(2)>

Additional information [?]

Size range 257-343 amino acids
Related rules MF_03205
Fusion Nter: None Cter: None

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