HAMAP rule MF_03202
General rule information
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Accession | MF_03202 |
Dates | 16-DEC-2013 (Created) 29-SEP-2022 (Last updated, Version 12) |
Name | VLCF_elongase_2 |
Scope | Eukaryota; Vertebrata |
Templates | Q9NXB9 (ELOV2_HUMAN); Q9JLJ4 (ELOV2_MOUSE); D4A612 (ELOV2_RAT): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
Catalytic activity | RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
EC 2.3.1.199 |
Pathway | Lipid metabolism; polyunsaturated fatty acid biosynthesis. |
Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
case <FTTag:ERmotif>
Domain | The C-terminal di-lysine motif may confer endoplasmic reticulum localization. |
end case
Similarity | Belongs to the ELO family. ELOVL2 subfamily. |
Keywords
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Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase
Gene Ontology
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GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.
Cross-references
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Computed features
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General | Transmembrane; -; 7; trigger=yes; |
Features
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From: ELOV2_HUMAN (Q9NXB9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | Cter-3 | Cter | Di-lysine motif | ERmotif | K-K-x(2)> |
Additional information
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Size range | 257-343 amino acids |
Related rules | MF_03205 (ELOV5) |
Fusion | None |