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Annotation rule MF_03204 |
Accession | MF_03204 |
Dates | 16-DEC-2013 (Created) 20-NOV-2019 (Last updated, Version 11) |
Name | VLCF_elongase_4 |
Scope | Eukaryota; Vertebrata |
Template | Q9GZR5 (ELOV4_HUMAN) |
Triggered by |
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Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. |
Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
Catalytic activity | RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
EC 2.3.1.199 |
Pathway | Lipid metabolism; fatty acid biosynthesis. |
Subunit | Oligomer. |
Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Domain | The C-terminal di-lysine motif may confer endoplasmic reticulum localization. |
Similarity | Belongs to the ELO family. ELOVL4 subfamily. |
PROSITE | PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=PRU00498; |
PS01188; ELO; 1; | |
Pfam | PF01151; ELO; 1; |
General | N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes; |
Transmembrane; -; 7; trigger=yes; |
From: ELOV4_HUMAN (Q9GZR5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | Cter-4 | Cter | Di-lysine motif | ERmotif | K-x-K-x(2)> |