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Annotation rule MF_03204
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General rule information [?]

Accession MF_03204
Dates 16-DEC-2013 (Created)
20-NOV-2019 (Last updated, Version 11)
Name VLCF_elongase_4
Scope
Eukaryota; Vertebrata
Template Q9GZR5 (ELOV4_HUMAN)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ELOV4
Protein name
RecName: Full=Elongation of very long chain fatty acids protein 4;
EC 2.3.1.199;
AltName: Full=3-keto acyl-CoA synthase ;
AltName: Full=ELOVL fatty acid elongase 4;
Short=ELOVL FA elongase 4;
AltName: Full=Very long chain 3-ketoacyl-CoA synthase 4;
AltName: Full=Very long chain 3-oxoacyl-CoA synthase 4;
Gene name
ELOVL4

Comments [?]

case <OC:Mammalia>
Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
else
Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
end case
Catalytic activity RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
EC 2.3.1.199
Pathway Lipid metabolism; fatty acid biosynthesis.
Subunit Oligomer.
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
case <FTTag:ERmotif>
Domain The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
end case
Similarity Belongs to the ELO family. ELOVL4 subfamily.

Keywords [?]

Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0019367; Biological process: fatty acid elongation, saturated fatty acid.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.

Cross-references [?]

PROSITE PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=PRU00498;
PS01188; ELO; 1;
Pfam PF01151; ELO; 1;

Computed features [?]

General N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes;
Transmembrane; -; 7; trigger=yes;

Features [?]

From: ELOV4_HUMAN (Q9GZR5)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     Cter-4     Cter       Di-lysine motif   ERmotif   K-x-K-x(2)>  

Additional information [?]

Size range 272-320 amino acids
Related rules MF_03201 (ELOV1); MF_03207 (ELOV7)
Fusion None


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