HAMAP rule MF_03205

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_03205
Accession	MF_03205
Dates	16-DEC-2013 (Created) 03-SEP-2024 (Last updated, Version 12)
Name	VLCF_elongase_5
Scope(s)	Eukaryota Vertebrata
Template(s)	Q2KJD9; Q920L7; [ Recover all ]
Triggered by	HAMAP; MF_03205 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ELOV5
Protein name	RecName: Full=Elongation of very long chain fatty acids protein 5; EC=2.3.1.199; AltName: Full=3-keto acyl-CoA synthase ; AltName: Full=ELOVL fatty acid elongase 5; Short=ELOVL FA elongase 5; AltName: Full=Very long chain 3-ketoacyl-CoA synthase 5; AltName: Full=Very long chain 3-oxoacyl-CoA synthase 5;
Gene name	Name=ELOVL5;

Comments [?]

FUNCTION	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
CATALYTIC ACTIVITY	Reaction=a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199;
PATHWAY	Lipid metabolism; polyunsaturated fatty acid biosynthesis.
SUBCELLULAR LOCATION	Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree.
SIMILARITY	Belongs to the ELO family. ELOVL5 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane

GO:0016020; Cellular component:membrane

GO:0009922; Molecular function:fatty acid elongase activity

GO:0034625; Biological process:fatty acid elongation, monounsaturated fatty acid

GO:0034626; Biological process:fatty acid elongation, polyunsaturated fatty acid

GO:0035338; Biological process:long-chain fatty-acyl-CoA biosynthetic process

GO:0006636; Biological process:unsaturated fatty acid biosynthetic process

GO:0042761; Biological process:very long-chain fatty acid biosynthetic process

Cross-references [?]

Features [?]

Additional information [?]