HAMAP rule MF_03205
General rule information
[?]
Accession | MF_03205 |
Dates | 16-DEC-2013 (Created) 29-SEP-2022 (Last updated, Version 10) |
Name | VLCF_elongase_5 |
Scope | Eukaryota; Vertebrata |
Templates | Q2KJD9 (ELOV5_BOVIN); Q920L7 (ELOV5_RAT): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
Catalytic activity | RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
EC 2.3.1.199 |
Pathway | Lipid metabolism; polyunsaturated fatty acid biosynthesis. |
Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. |
Similarity | Belongs to the ELO family. ELOVL5 subfamily. |
Keywords
[?]
Cell projection
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase
Gene Ontology
[?]
GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0034625; Biological process: fatty acid elongation, monounsaturated fatty acid.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0034625; Biological process: fatty acid elongation, monounsaturated fatty acid.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.
Cross-references
[?]
Computed features
[?]
General | Transmembrane; -; 7; trigger=yes; |
Additional information
[?]
Size range | 269-300 amino acids |
Related rules | MF_03202 (ELOV2) |
Fusion | None |