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HAMAP rule MF_03205

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General rule information [?]

Accession MF_03205
Dates 16-DEC-2013 (Created)
29-SEP-2022 (Last updated, Version 10)
Name VLCF_elongase_5
Eukaryota; Vertebrata
Templates Q2KJD9 (ELOV5_BOVIN); Q920L7 (ELOV5_RAT): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Elongation of very long chain fatty acids protein 5;
AltName: Full=3-keto acyl-CoA synthase ;
AltName: Full=ELOVL fatty acid elongase 5;
Short=ELOVL FA elongase 5;
AltName: Full=Very long chain 3-ketoacyl-CoA synthase 5;
AltName: Full=Very long chain 3-oxoacyl-CoA synthase 5;
Gene name

Comments [?]

Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalytic activity RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
Pathway Lipid metabolism; polyunsaturated fatty acid biosynthesis.
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree.
Similarity Belongs to the ELO family. ELOVL5 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0034625; Biological process: fatty acid elongation, monounsaturated fatty acid.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.

Cross-references [?]

PROSITE PS01188; ELO; 1;
Pfam PF01151; ELO; 1;

Computed features [?]

General Transmembrane; -; 7; trigger=yes;

Additional information [?]

Size range 269-300 amino acids
Related rules MF_03202 (ELOV2)
Fusion None