HAMAP rule MF_03205

Accession	MF_03205
Dates	16-DEC-2013 (Created) 29-SEP-2022 (Last updated, Version 10)

Name	VLCF_elongase_5

Scope

Eukaryota; Vertebrata

Templates

Q2KJD9 (ELOV5_BOVIN); Q920L7 (ELOV5_RAT): [Recover all]

Triggered by

HAMAP; MF_03205 (Get profile general information and statistics)

Identifier

ELOV5

Protein name

RecName: Full=Elongation of very long chain fatty acids protein 5; EC 2.3.1.199; AltName: Full=3-keto acyl-CoA synthase ; AltName: Full=ELOVL fatty acid elongase 5; Short=ELOVL FA elongase 5; AltName: Full=Very long chain 3-ketoacyl-CoA synthase 5; AltName: Full=Very long chain 3-oxoacyl-CoA synthase 5;

Gene name

ELOVL5

Function	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalytic activity	RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA EC 2.3.1.199
Pathway	Lipid metabolism; polyunsaturated fatty acid biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree.
Similarity	Belongs to the ELO family. ELOVL5 subfamily.

Cell projection
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0034625; Biological process: fatty acid elongation, monounsaturated fatty acid.
GO:0034626; Biological process: fatty acid elongation, polyunsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0042761; Biological process: very long-chain fatty acid biosynthetic process.

PROSITE	PS01188; ELO; 1;
Pfam	PF01151; ELO; 1;

General

Transmembrane; -; 7; trigger=yes;

Size range	269-300 amino acids
Related rules	MF_03202 (ELOV2)
Fusion	None

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