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HAMAP rule MF_03206

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General rule information [?]

Accession MF_03206
Dates 16-DEC-2013 (Created)
29-SEP-2022 (Last updated, Version 11)
Name VLCF_elongase_6
Scope(s) Eukaryota
Template(s) Q9H5J4 (ELOV6_HUMAN); Q920L5 (ELOV6_MOUSE); Q920L6 (ELOV6_RAT); [ Recover all ]
Triggered by HAMAP; MF_03206 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ELOV6
Protein name RecName: Full=Elongation of very long chain fatty acids protein 6;
AltName: Full=3-keto acyl-CoA synthase ;
AltName: Full=ELOVL fatty acid elongase 6;
                 Short=ELOVL FA elongase 6;
AltName: Full=Very long chain 3-ketoacyl-CoA synthase 6;
AltName: Full=Very long chain 3-oxoacyl-CoA synthase 6;
Gene name Name=ELOVL6;

Comments [?]

FUNCTIONCatalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
CATALYTIC ACTIVITY Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long- chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=;
PATHWAYLipid metabolism; fatty acid biosynthesis.
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein.
case <FTTag:ERmotif>
DOMAINThe C-terminal di-lysine motif may confer endoplasmic reticulum localization.
end case
SIMILARITYBelongs to the ELO family. ELOVL6 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0016020; Cellular component:membrane
GO:0009922; Molecular function:fatty acid elongase activity
GO:0006636; Biological process:unsaturated fatty acid biosynthetic process
GO:0019367; Biological process:fatty acid elongation, saturated fatty acid
GO:0034625; Biological process:fatty acid elongation, monounsaturated fatty acid
GO:0035338; Biological process:long-chain fatty-acyl-CoA biosynthetic process

Cross-references [?]

PROSITE PS01188; ELO; 1;
Pfam PF01151; ELO; 1;
General N_glycosylation; NetNGlyc; 0-unlimited;
General Transmembrane; -; 7;

Features [?]

From: ELOV6_HUMAN (Q9H5J4)
Key From To Description Tag Condition FTGroup
MOTIF Cter-3 Cter /note="Di-lysine motif" ERmotif K-x(2)-K>

Additional information [?]

Size range 262-271 amino acids
Related rules MF_03203
Fusion Nter: None Cter: None

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