HAMAP rule MF_03206
General rule information
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Accession | MF_03206 |
Dates | 16-DEC-2013 (Created) 29-SEP-2022 (Last updated, Version 11) |
Name | VLCF_elongase_6 |
Scope | Eukaryota; Vertebrata |
Templates | Q9H5J4 (ELOV6_HUMAN); Q920L5 (ELOV6_MOUSE); Q920L6 (ELOV6_RAT): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
Catalytic activity | RHEA:32727: a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
EC 2.3.1.199 |
Pathway | Lipid metabolism; fatty acid biosynthesis. |
Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
case <FTTag:ERmotif>
Domain | The C-terminal di-lysine motif may confer endoplasmic reticulum localization. |
end case
Ptm | N-Glycosylated. |
Similarity | Belongs to the ELO family. ELOVL6 subfamily. |
Keywords
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Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Glycoprotein
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase
Fatty acid biosynthesis
Fatty acid metabolism
Glycoprotein
Lipid biosynthesis
Lipid metabolism
Membrane
Transferase
Gene Ontology
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GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0019367; Biological process: fatty acid elongation, saturated fatty acid.
GO:0034625; Biological process: fatty acid elongation, monounsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
GO:0016020; Cellular component: membrane.
GO:0009922; Molecular function: fatty acid elongase activity.
GO:0006636; Biological process: unsaturated fatty acid biosynthetic process.
GO:0019367; Biological process: fatty acid elongation, saturated fatty acid.
GO:0034625; Biological process: fatty acid elongation, monounsaturated fatty acid.
GO:0035338; Biological process: long-chain fatty-acyl-CoA biosynthetic process.
Cross-references
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PROSITE | PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=PRU00498; |
PS01188; ELO; 1; | |
Pfam | PF01151; ELO; 1; |
Computed features
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General | N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes; |
Transmembrane; -; 7; trigger=yes; |
Features
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From: ELOV6_HUMAN (Q9H5J4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | Cter-3 | Cter | Di-lysine motif | ERmotif | K-x(2)-K> |
Additional information
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Size range | 262-271 amino acids |
Related rules | MF_03203 (ELOV3) |
Fusion | None |