HAMAP rule MF_03208
General rule information
[?]
| Accession | MF_03208 |
| Dates | 6-JAN-2016 (Created) 29-SEP-2022 (Last updated, Version 7) |
| Name | PS_decarb_PSD_B_type1_euk |
| Scope | Eukaryota |
| Templates | B3L2V1 (PSD_PLAKH); P39006 (PSD1_YEAST): [Recover all] |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Plasmodiidae>
| Identifier |
|
| Protein name |
|
||||||||||||||||||||||||||||
else case <OC:Fungi> or <OC:Viridiplantae>
| Identifier |
|
| Protein name |
|
||||||||||||||||||||||||||||
else
| Identifier |
|
| Protein name |
|
||||||||||||||||||||||||||||
end case
case <OC:Vertebrata>
| Gene name |
|
else case <OC:Caenorhabditis>
| Gene name |
|
else case <OC:Fungi>
| Gene name |
|
end case
Comments
[?]
| Function | Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. |
| Catalytic activity | RHEA:20828: a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2
EC 4.1.1.65 |
| Cofactor | pyruvate Note: Binds 1 pyruvoyl group covalently per subunit. |
case not <OC:Vertebrata>
| Pathway | Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. |
end case
| Subunit | Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. |
case <OC:Plasmodiidae>
| Subcellular location | Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Equally found in the membrane-bound as well as in the soluble fraction. |
else case (<OC:Fungi> or <OC:Viridiplantae>)
| Subcellular location | Phosphatidylserine decarboxylase 1 beta chain: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. |
| Phosphatidylserine decarboxylase 1 alpha chain: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain. |
else
| Subcellular location | Phosphatidylserine decarboxylase beta chain: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. |
| Phosphatidylserine decarboxylase alpha chain: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain. |
end case
| Ptm | Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase. |
| Similarity | Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily. |
case not <AnyFeature:TransitM> and not <OC:Apicomplexa>
| Miscellaneous | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Keywords
[?]
case <OC:Plasmodiidae>
else
end case
Gene Ontology
[?]
case <OC:Plasmodiidae>
GO:0005789; Cellular component: endoplasmic reticulum membrane.
else
GO:0005743; Cellular component: mitochondrial inner membrane.
end case
GO:0004609; Molecular function: phosphatidylserine decarboxylase activity.
GO:0006646; Biological process: phosphatidylethanolamine biosynthetic process.
GO:0016540; Biological process: protein autoprocessing.
GO:0006646; Biological process: phosphatidylethanolamine biosynthetic process.
GO:0016540; Biological process: protein autoprocessing.
Cross-references
[?]
Computed features
[?]
case not <OC:Apicomplexa>
| General | TransitM; -; 0-1; trigger=yes; |
end case
Features
[?]
case <OC:Fungi> or <OC:Viridiplantae>
| From: PSD_PLAKH (B3L2V1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| CHAIN | Nter | 307 | Phosphatidylserine decarboxylase 1 beta chain | |||||||||
| CHAIN | 308 | Cter | Phosphatidylserine decarboxylase 1 alpha chain | |||||||||
else
| CHAIN | Nter | 307 | Phosphatidylserine decarboxylase beta chain | |||||||||
| CHAIN | 308 | Cter | Phosphatidylserine decarboxylase alpha chain |
end case
case not <OC:Plasmodiidae>
end case
Additional information
[?]
| Size range | 336-655 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Classification of phosphatidylserine decarboxylase into subfamilies was done according to Daiyasu at al.(2005) (PubMed:16243780) for PSD-A and PSD-B and Voelker D.R.(1997) (PubMed:9370338) for type I and type II. |