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Annotation rule MF_03216
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General rule information [?]

Accession MF_03216
Dates 7-JUL-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Name PLMT
Scope
Eukaryota
Templates Q9UBM1 (PEMT_HUMAN); P05375 (PLMT_YEAST); Q7S5W9 (PLMT_NEUCR); Q61907 (PEMT_MOUSE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Fungi> or <OC:Viridiplantae>
Identifier
PLMT
Protein name
RecName: Full=Phosphatidyl-N-methylethanolamine N-methyltransferase;
EC 2.1.1.71;
AltName: Full=Phospholipid methyltransferase;
Short=PLMT;
else
Identifier
PEMT
Protein name
RecName: Full=Phosphatidylethanolamine N-methyltransferase;
Short=PEAMT;
Short=PEMT;
EC 2.1.1.17;
EC 2.1.1.71;
AltName: Full=Phospholipid methyltransferase;
Short=PLMT;
end case
case <OC:Vertebrata>
Gene name
PEMT
end case

Comments [?]

case <OC:Fungi> or <OC:Viridiplantae>
Function Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
else
Function Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC).
end case
Catalytic activity RHEA:32735: 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.71
RHEA:32739: 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
case not (<OC:Fungi> or <OC:Viridiplantae>)
Catalytic activity RHEA:11164: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.17
end case
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis.
case <OC:Vertebrata>
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria.
else case <OC:Viridiplantae>
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
else
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.

Keywords [?]

Endoplasmic reticulum
Lipid biosynthesis
Lipid metabolism
Membrane
Methyltransferase
case not <OC:Viridiplantae>
Mitochondrion
end case
Phospholipid biosynthesis
Phospholipid metabolism
S-adenosyl-L-methionine
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
case not <OC:Viridiplantae>
GO:0031966; Cellular component: mitochondrial membrane.
end case
GO:0080101; Molecular function: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity.
GO:0000773; Molecular function: phosphatidyl-N-methylethanolamine N-methyltransferase activity.
case not <OC:Fungi>
GO:0004608; Molecular function: phosphatidylethanolamine N-methyltransferase activity.
end case
GO:0006656; Biological process: phosphatidylcholine biosynthetic process.

Cross-references [?]

PROSITE PS51599; SAM_PEMT_PEM2; 1;
PS50244; S5A_REDUCTASE; 1;
Pfam PF04191; PEMT; 1;
PIRSF PIRSF005444; PEMT; 1;

Features [?]

From: PEMT_HUMAN (Q9UBM1)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     12       Lumenal        
INTRAMEM     13     33       Helical        
TOPO_DOM     34     45       Lumenal        
TRANSMEM     46     66       Helical        
TOPO_DOM     67     93       Cytoplasmic        
TRANSMEM     94     114       Helical        
TOPO_DOM     115     157       Lumenal        
TRANSMEM     158     178       Helical        
TOPO_DOM     179     Cter       Cytoplasmic        
REGION     98     100       S-adenosyl-L-methionine binding     x(2)-G  
REGION     180     181       S-adenosyl-L-methionine binding     E-x  

Additional information [?]

Size range 164-248 amino acids
Related rules None
Fusion None


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