 |
|
Annotation rule MF_03216 |
General rule information
[?]
Accession |
MF_03216 |
Dates |
7-JUL-2016 (Created) 20-NOV-2019 (Last updated, Version 4) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Fungi> or <OC:Viridiplantae>
Protein name |
RecName:
|
Full=Phosphatidyl-N-methylethanolamine N-methyltransferase;
|
|
EC 2.1.1.71;
|
AltName:
|
Full=Phospholipid methyltransferase;
|
|
Short=PLMT;
|
|
else
Protein name |
RecName:
|
Full=Phosphatidylethanolamine N-methyltransferase;
|
|
Short=PEAMT;
|
|
Short=PEMT;
|
|
EC 2.1.1.17;
|
|
EC 2.1.1.71;
|
AltName:
|
Full=Phospholipid methyltransferase;
|
|
Short=PLMT;
|
|
end case
case <OC:Vertebrata>
end case
case <OC:Fungi> or <OC:Viridiplantae>
Function |
Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC). |
else
Function |
Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC). |
end case
Catalytic activity |
RHEA:32735: 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.71
|
|
RHEA:32739: 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
|
case not (<OC:Fungi> or <OC:Viridiplantae>)
Catalytic activity |
RHEA:11164: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.17
|
end case
Pathway |
Phospholipid metabolism; phosphatidylcholine biosynthesis. |
case <OC:Vertebrata>
Subcellular location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. |
else case <OC:Viridiplantae>
Subcellular location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. |
else
Subcellular location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. |
end case
Similarity |
Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. |
case not <OC:Viridiplantae>
end case
GO:0005789; Cellular component: endoplasmic reticulum membrane.
case not <OC:Viridiplantae>
GO:0031966; Cellular component: mitochondrial membrane.
end case
GO:0080101; Molecular function: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity.
GO:0000773; Molecular function: phosphatidyl-N-methylethanolamine N-methyltransferase activity.
case not <OC:Fungi>
GO:0004608; Molecular function: phosphatidylethanolamine N-methyltransferase activity.
end case
GO:0006656; Biological process: phosphatidylcholine biosynthetic process.
From: PEMT_HUMAN (Q9UBM1) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
TOPO_DOM
|
|
Nter
|
|
12
|
|
Lumenal
|
|
|
|
|
|
|
INTRAMEM
|
|
13
|
|
33
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
34
|
|
45
|
|
Lumenal
|
|
|
|
|
|
|
TRANSMEM
|
|
46
|
|
66
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
67
|
|
93
|
|
Cytoplasmic
|
|
|
|
|
|
|
TRANSMEM
|
|
94
|
|
114
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
115
|
|
157
|
|
Lumenal
|
|
|
|
|
|
|
TRANSMEM
|
|
158
|
|
178
|
|
Helical
|
|
|
|
|
|
|
TOPO_DOM
|
|
179
|
|
Cter
|
|
Cytoplasmic
|
|
|
|
|
|
|
REGION
|
|
98
|
|
100
|
|
S-adenosyl-L-methionine binding
|
|
|
|
x(2)-G
|
|
|
REGION
|
|
180
|
|
181
|
|
S-adenosyl-L-methionine binding
|
|
|
|
E-x
|
|
|
Additional information
[?]
Size range |
164-248 amino acids |
Related rules |
None |
Fusion |
None |