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HAMAP rule MF_03223

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General rule information [?]

Accession MF_03223
Dates 28-MAR-2017 (Created)
19-NOV-2022 (Last updated, Version 6)
Name Methyltr_EFM7
Scope
Eukaryota; Fungi
Template Q05874 (EFM7_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
EFM7
Protein name
RecName: Full=Protein N-terminal and lysine N-methyltransferase EFM7;
EC 2.1.1.-;
AltName: Full=Elongation factor methyltransferase 7;
Gene name
EFM7

Comments [?]

Function S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
Subcellular location Cytoplasm.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.

Keywords [?]

Cytoplasm
Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0071885; Molecular function: N-terminal protein N-methyltransferase activity.
GO:0016279; Molecular function: protein-lysine N-methyltransferase activity.
GO:0018013; Biological process: N-terminal peptidyl-glycine methylation.
GO:0018027; Biological process: peptidyl-lysine dimethylation.

Cross-references [?]

PROSITE PS51560; SAM_MT_NNT1; 1;
Pfam PF10294; Methyltransf_16; 1;

Features [?]

From: EFM7_YEAST (Q05874)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     90     92       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     G-A-[GA]  
BINDING     64     64       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     W  
BINDING     112     112       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     D  
BINDING     144     144       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     W  
BINDING     171     171       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [SA]  

Additional information [?]

Size range 254-299 amino acids
Related rules None
Fusion None


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