HAMAP rule MF_03223

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_03223
Accession	MF_03223
Dates	28-MAR-2017 (Created) 19-NOV-2022 (Last updated, Version 7)
Name	Methyltr_EFM7
Scope(s)	Eukaryota Fungi
Template(s)	Q05874; [ Recover all ]
Triggered by	HAMAP; MF_03223 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	EFM7
Protein name	RecName: Full=Protein N-terminal and lysine N-methyltransferase EFM7; EC=2.1.1.-; AltName: Full=Elongation factor methyltransferase 7;
Gene name	Name=EFM7;

Comments [?]

FUNCTION	S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm

GO:0071885; Molecular function:N-terminal protein N-methyltransferase activity

GO:0016279; Molecular function:protein-lysine N-methyltransferase activity

GO:0018013; Biological process:N-terminal peptidyl-glycine methylation

GO:0018027; Biological process:peptidyl-lysine dimethylation

Cross-references [?]

PROSITE	PS51560; SAM_MT_NNT1; 1;
Pfam	PF10294; Methyltransf_16; 1;

Features [?]

From: EFM7_YEAST (Q05874)

Key

From

Description

Tag

Condition

FTGroup

BINDING