HAMAP rule MF_03223
General rule information
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Accession | MF_03223 |
Dates | 28-MAR-2017 (Created)
19-NOV-2022 (Last updated, Version 6) |
Name | Methyltr_EFM7 |
Scope(s) |
Eukaryota Fungi |
Template(s) | Q05874 (EFM7_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03223 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | EFM7 |
Protein name | RecName: Full=Protein N-terminal and lysine N-methyltransferase EFM7; EC=2.1.1.-; AltName: Full=Elongation factor methyltransferase 7; |
Gene name | Name=EFM7; |
Comments
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FUNCTION | S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family. |
Keywords
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Gene Ontology
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GO:0005737; Cellular component:cytoplasm |
GO:0071885; Molecular function:N-terminal protein N-methyltransferase activity |
GO:0016279; Molecular function:protein-lysine N-methyltransferase activity |
GO:0018013; Biological process:N-terminal peptidyl-glycine methylation |
GO:0018027; Biological process:peptidyl-lysine dimethylation |
Cross-references
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Features
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From: EFM7_YEAST (Q05874) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 90 | 92 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G-A-[GA] | ||||||||
BINDING | 64 | 64 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
W | ||||||||
BINDING | 112 | 112 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
BINDING | 144 | 144 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
W | ||||||||
BINDING | 171 | 171 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[SA] |
Additional information
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Size range | 254-299 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |