HAMAP rule MF_03229
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03229 |
| Accession | MF_03229 |
| Dates | 11-NOV-2020 (Created)
11-NOV-2020 (Last updated, Version 2) |
| Name | FITM1 |
| Scope(s) |
Eukaryota Euteleostomi |
| Template(s) | A5D6W6 (FITM1_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03229 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FITM1 |
| case <FTGroup:1> | |
| Protein name | RecName: Full=Fat storage-inducing transmembrane protein 1; AltName: Full=Fat-inducing protein 1; |
| else | |
| Protein name | RecName: Full=Fat storage-inducing transmembrane protein 1 homolog; AltName: Full=FITM1-like protein; AltName: Full=Fat-inducing protein 1; |
| end case | |
| Gene name | Name=FITM1; Synonyms=FIT1; |
Comments
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| case <FTGroup:1> and <OC:Mammalia> | |
| FUNCTION | Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol. |
| else case <FTGroup:1> | |
| FUNCTION | Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol. |
| else | |
| FUNCTION | May play a role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol. |
| end case | |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the FIT family. FIT1 subfamily. |
Keywords
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Gene Ontology
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| GO:0005789; Cellular component:endoplasmic reticulum membrane |
| GO:0140042; Biological process:lipid droplet formation |
Cross-references
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| Pfam | PF10261; Scs3p; 0-1; |
| General | Transmembrane; -; 7; |
Features
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| From: FITM1_HUMAN (A5D6W6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 186 | 186 | H | 1 | ||||||||
| ACT_SITE | 244 | 244 | H | 1 | ||||||||
| case <FTGroup:1> | ||||||||||||
| SITE | 248 | 248 | /note="Important for catalytic activity" | [HQDE] | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 253-327 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |