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HAMAP rule MF_03229

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General rule information [?]

Accession MF_03229
Dates 11-NOV-2020 (Created)
11-NOV-2020 (Last updated, Version 2)
Name FITM1
Scope
Eukaryota; Euteleostomi
Template A5D6W6 (FITM1_HUMAN)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FITM1
case <FTGroup:1>
Protein name
RecName: Full=Fat storage-inducing transmembrane protein 1;
AltName: Full=Fat-inducing protein 1;
else
Protein name
RecName: Full=Fat storage-inducing transmembrane protein 1 homolog;
AltName: Full=FITM1-like protein;
AltName: Full=Fat-inducing protein 1;
end case
Gene name
FITM1, FIT1

Comments [?]

case <FTGroup:1> and <OC:Mammalia>
Function Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.
else case <FTGroup:1>
Function Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol.
else
Function May play a role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol.
end case
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Similarity Belongs to the FIT family. FIT1 subfamily.

Keywords [?]

Endoplasmic reticulum
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0140042; Biological process: lipid droplet formation.

Cross-references [?]

Pfam PF10261; Scs3p; 0-1;

Computed features [?]

General Transmembrane; -; 7;

Features [?]

From: FITM1_HUMAN (A5D6W6)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     186     186             H   1
ACT_SITE     244     244             H   1
case <FTGroup:1>
SITE     248     248       Important for catalytic activity     [HQDE]  
end case

Additional information [?]

Size range 253-327 amino acids
Related rules None
Fusion None


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