HAMAP rule MF_03230
General rule information
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Accession | MF_03230 |
Dates | 11-NOV-2020 (Created) 20-MAY-2021 (Last updated, Version 3) |
Name | FITM2 |
Scope | Eukaryota; Bilateria |
Template | Q8N6M3 (FITM2_HUMAN) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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case <FTGroup:1>
Protein name |
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else
Protein name |
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end case
Gene name |
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Comments
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case <FTGroup:1> and <OC:Mammalia>
Function | Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. Plays a role in the regulation of cell morphology and cytoskeletal organization. |
Catalytic activity | RHEA:50044: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
PhysiologicalDirection=left-to-right (RHEA:50045) |
RHEA:65564: (9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:65565) |
|
RHEA:65568: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:65569) |
|
RHEA:50032: H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:50033) |
else case <FTGroup:1>
Function | Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology, ER morphology and cytoskeletal organization. |
Catalytic activity | RHEA:50044: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
PhysiologicalDirection=left-to-right (RHEA:50045) |
else
Function | May hydrolyze fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. |
end case
Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Similarity | Belongs to the FIT family. FIT2 subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.
end case
GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0140042; Biological process: lipid droplet formation.
GO:0140042; Biological process: lipid droplet formation.
Cross-references
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Pfam | PF10261; Scs3p; 1-2; |
Computed features
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General | Transmembrane; -; 0-6; |
Features
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From: FITM2_HUMAN (Q8N6M3) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 155 | 155 | H | 1 | ||||||||
ACT_SITE | 214 | 214 | H | 1 |
Additional information
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Size range | 252-448 amino acids |
Related rules | None |
Fusion | None |