HAMAP rule MF_03230
General rule information
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| Accession | MF_03230 |
| Dates | 11-NOV-2020 (Created)
3-SEP-2024 (Last updated, Version 4) |
| Name | FITM2 |
| Scope(s) |
Eukaryota Bilateria |
| Template(s) | Q8N6M3 (FITM2_HUMAN); [ Recover all ] |
| Triggered by |
HAMAP; MF_03230 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FITM2 |
| case <FTGroup:1> | |
| Protein name | RecName: Full=Acyl-coenzyme A diphosphatase FITM2; EC=3.6.1.-; AltName: Full=Fat storage-inducing transmembrane protein 2; AltName: Full=Fat-inducing protein 2; |
| else | |
| Protein name | RecName: Full=Acyl-coenzyme A diphosphatase FITM2 homolog; AltName: Full=Fat storage-inducing transmembrane protein 2 homolog; AltName: Full=FITM2-like protein; |
| end case | |
| Gene name | Name=FITM2; Synonyms=FIT2; |
Comments
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| case <FTGroup:1> and <OC:Mammalia> | |
| FUNCTION | Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl- CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. Plays a role in the regulation of cell morphology and cytoskeletal organization. |
| CATALYTIC ACTIVITY | Reaction=an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045; |
| CATALYTIC ACTIVITY | Reaction=(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'- phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+); Xref=Rhea:RHEA:65564, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57387, ChEBI:CHEBI:58343, ChEBI:CHEBI:156553; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65565; |
| CATALYTIC ACTIVITY | Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'- bisphosphate + 2 H(+); Xref=Rhea:RHEA:65568, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57368, ChEBI:CHEBI:58343, ChEBI:CHEBI:156554; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65569; |
| CATALYTIC ACTIVITY | Reaction=hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+); Xref=Rhea:RHEA:50032, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:58343, ChEBI:CHEBI:132018; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50033; |
| else case <FTGroup:1> | |
| FUNCTION | Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology, ER morphology and cytoskeletal organization. |
| CATALYTIC ACTIVITY | Reaction=an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045; |
| else | |
| FUNCTION | May hydrolyze fatty acyl-CoA to yield acyl-4'- phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. |
| end case | |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the FIT family. FIT2 subfamily. |
Keywords
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| case <FTGroup:1> | |
| Hydrolase | |
| Lipid metabolism | |
| end case | |
| Endoplasmic reticulum | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
| end case | |
| GO:0005789; Cellular component:endoplasmic reticulum membrane | |
| GO:0140042; Biological process:lipid droplet formation | |
Cross-references
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| Pfam | PF10261; Scs3p; 1-2; |
| General | Transmembrane; -; 0-6; |
Features
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| From: FITM2_HUMAN (Q8N6M3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 155 | 155 | H | 1 | ||||||||
| ACT_SITE | 214 | 214 | H | 1 | ||||||||
Additional information
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| Size range | 252-448 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |