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HAMAP rule MF_03230

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General rule information [?]

Accession MF_03230
Dates 11-NOV-2020 (Created)
20-MAY-2021 (Last updated, Version 3)
Name FITM2
Scope
Eukaryota; Bilateria
Template Q8N6M3 (FITM2_HUMAN)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FITM2
case <FTGroup:1>
Protein name
RecName: Full=Acyl-coenzyme A diphosphatase FITM2;
EC 3.6.1.-;
AltName: Full=Fat storage-inducing transmembrane protein 2;
AltName: Full=Fat-inducing protein 2;
else
Protein name
RecName: Full=Acyl-coenzyme A diphosphatase FITM2 homolog;
AltName: Full=Fat storage-inducing transmembrane protein 2 homolog;
AltName: Full=FITM2-like protein;
end case
Gene name
FITM2, FIT2

Comments [?]

case <FTGroup:1> and <OC:Mammalia>
Function Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Catalytic activity RHEA:50044: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
PhysiologicalDirection=left-to-right (RHEA:50045)
RHEA:65564: (9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:65565)
RHEA:65568: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:65569)
RHEA:50032: H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:50033)
else case <FTGroup:1>
Function Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology, ER morphology and cytoskeletal organization.
Catalytic activity RHEA:50044: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
PhysiologicalDirection=left-to-right (RHEA:50045)
else
Function May hydrolyze fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis.
end case
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Similarity Belongs to the FIT family. FIT2 subfamily.

Keywords [?]

case <FTGroup:1>
Hydrolase
Lipid metabolism
end case
Endoplasmic reticulum
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

case <FTGroup:1>
GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.
end case
GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0140042; Biological process: lipid droplet formation.

Cross-references [?]

Pfam PF10261; Scs3p; 1-2;

Computed features [?]

General Transmembrane; -; 0-6;

Features [?]

From: FITM2_HUMAN (Q8N6M3)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     155     155             H   1
ACT_SITE     214     214             H   1

Additional information [?]

Size range 252-448 amino acids
Related rules None
Fusion None


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