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HAMAP rule MF_03230

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General rule information [?]

Accession MF_03230
Dates 11-NOV-2020 (Created)
20-MAY-2021 (Last updated, Version 3)
Name FITM2
Scope(s) Eukaryota
Bilateria
Template(s) Q8N6M3 (FITM2_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_03230 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FITM2
case <FTGroup:1>
Protein name RecName: Full=Acyl-coenzyme A diphosphatase FITM2;
                 EC=3.6.1.-;
AltName: Full=Fat storage-inducing transmembrane protein 2;
AltName: Full=Fat-inducing protein 2;
else
Protein name RecName: Full=Acyl-coenzyme A diphosphatase FITM2 homolog;
AltName: Full=Fat storage-inducing transmembrane protein 2 homolog;
AltName: Full=FITM2-like protein;
end case
Gene name Name=FITM2; Synonyms=FIT2;

Comments [?]

case <FTGroup:1> and <OC:Mammalia>
FUNCTIONFatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl- CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
CATALYTIC ACTIVITY Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045;
CATALYTIC ACTIVITY Reaction=(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:65564, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57387, ChEBI:CHEBI:58343, ChEBI:CHEBI:156553; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65565;
CATALYTIC ACTIVITY Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'- bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'- phosphopantetheine; Xref=Rhea:RHEA:65568, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57368, ChEBI:CHEBI:58343, ChEBI:CHEBI:156554; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65569;
CATALYTIC ACTIVITY Reaction=H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50032, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:58343, ChEBI:CHEBI:132018; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50033;
else case <FTGroup:1>
FUNCTIONFatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology, ER morphology and cytoskeletal organization.
CATALYTIC ACTIVITY Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045;
else
FUNCTIONMay hydrolyze fatty acyl-CoA to yield acyl-4'- phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis.
end case
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the FIT family. FIT2 subfamily.

Keywords [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
end case
GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0140042; Biological process:lipid droplet formation

Cross-references [?]

Pfam PF10261; Scs3p; 1-2;
General Transmembrane; -; 0-6;

Features [?]

From: FITM2_HUMAN (Q8N6M3)
Key From To Description Tag Condition FTGroup
ACT_SITE 155 155 H 1
ACT_SITE 214 214 H 1

Additional information [?]

Size range 252-448 amino acids
Related rules None
Fusion Nter: None Cter: None



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