HAMAP rule MF_03231

General rule information [?]

Accession	MF_03231
Dates	11-NOV-2020 (Created) 20-MAY-2021 (Last updated, Version 3)

Name

SCS3

Scope

Eukaryota; Ascomycota

Template

P53012 (SCS3_YEAST)

Triggered by

HAMAP; MF_03231 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SCS3

case <FTGroup:1>

Protein name

RecName:		Full=Acyl-coenzyme A diphosphatase SCS3;
		EC 3.6.1.-;
AltName:		Full=FIT family protein SCS3;

else

Protein name

RecName:		Full=Acyl-coenzyme A diphosphatase SCS3 homolog;
AltName:		Full=FIT family protein SCS3 homolog;

end case

Gene name

SCS3, FIT2B

Comments [?]

case <FTGroup:1>

Function	Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
Catalytic activity	RHEA:50044: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+) PhysiologicalDirection=left-to-right (RHEA:50045)
	RHEA:65564: (9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine PhysiologicalDirection=left-to-right (RHEA:65565)
	RHEA:65568: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine PhysiologicalDirection=left-to-right (RHEA:65569)
	RHEA:50032: H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine PhysiologicalDirection=left-to-right (RHEA:50033)

else

Function

May hydrolyze fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis.

end case

Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein.
Similarity	Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.

Keywords [?]

case <FTGroup:1>

Hydrolase
Lipid biosynthesis
Phospholipid biosynthesis
Phospholipid metabolism

end case

Endoplasmic reticulum
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

case <FTGroup:1>

GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.

end case

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0140042; Biological process: lipid droplet formation.

Cross-references [?]

Pfam	PF10261; Scs3p; 1-2;

Computed features [?]

General	Signal; -; 0-1;
	Transmembrane; -; 0-7;

Features [?]

From: SCS3_YEAST (P53012)

Key From To Description Tag Condition FTGroup

ACT_SITE 235 235 H 1

ACT_SITE 350 350 H 1

Additional information [?]

Size range	246-397 amino acids
Related rules	None
Fusion	None

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