HAMAP rule MF_03231

General rule information [?]

Accession	MF_03231
Dates	11-NOV-2020 (Created) 20-MAY-2021 (Last updated, Version 3)
Name	SCS3
Scope(s)	Eukaryota Ascomycota
Template(s)	P53012 (SCS3_YEAST); [ Recover all ]
Triggered by	HAMAP; MF_03231 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SCS3
case <FTGroup:1>
Protein name	RecName: Full=Acyl-coenzyme A diphosphatase SCS3; EC=3.6.1.-; AltName: Full=FIT family protein SCS3;
else
Protein name	RecName: Full=Acyl-coenzyme A diphosphatase SCS3 homolog; AltName: Full=FIT family protein SCS3 homolog;
end case
Gene name	Name=SCS3; Synonyms=FIT2B;

Comments [?]

case <FTGroup:1>
FUNCTION	Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
CATALYTIC ACTIVITY	Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045;
CATALYTIC ACTIVITY	Reaction=(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:65564, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57387, ChEBI:CHEBI:58343, ChEBI:CHEBI:156553; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65565;
CATALYTIC ACTIVITY	Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'- bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'- phosphopantetheine; Xref=Rhea:RHEA:65568, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57368, ChEBI:CHEBI:58343, ChEBI:CHEBI:156554; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65569;
CATALYTIC ACTIVITY	Reaction=H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50032, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:58343, ChEBI:CHEBI:132018; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50033;
else
FUNCTION	May hydrolyze fatty acyl-CoA to yield acyl-4'- phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis.
end case
SUBCELLULAR LOCATION	Endoplasmic reticulum membrane; Multi-pass membrane protein.
SIMILARITY	Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.

Keywords [?]

case <FTGroup:1>
Hydrolase
Lipid biosynthesis
Phospholipid biosynthesis
Phospholipid metabolism
end case
Endoplasmic reticulum
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

case <FTGroup:1>
GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
end case
GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0140042; Biological process:lipid droplet formation

Cross-references [?]

Pfam	PF10261; Scs3p; 1-2;
General	Signal; -; 0-1;
General	Transmembrane; -; 0-7;

Features [?]

From: SCS3_YEAST (P53012)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

235

ACT_SITE

350

Additional information [?]

Size range	246-397 amino acids
Related rules	None
Fusion	Nter: None Cter: None

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