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Annotation rule MF_03231
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General rule information [?]

Accession MF_03231
Dates 11-NOV-2020 (Created)
11-NOV-2020 (Last updated, Version 2)
Name SCS3
Scope
Eukaryota; Ascomycota
Template P53012 (SCS3_YEAST)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SCS3
case <FTGroup:1>
Protein name
RecName: Full=Acyl-coenzyme A diphosphatase SCS3;
EC 3.6.1.-;
AltName: Full=FIT family protein SCS3;
else
Protein name
RecName: Full=Acyl-coenzyme A diphosphatase SCS3 homolog;
AltName: Full=FIT family protein SCS3 homolog;
end case
Gene name
SCS3, FIT2B

Comments [?]

case <FTGroup:1>
Function Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
Catalytic activity RHEA:50044: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)
PhysiologicalDirection=left-to-right (RHEA:50045)
RHEA:65564: (9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:65565)
RHEA:65568: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:65569)
RHEA:50032: H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine
PhysiologicalDirection=left-to-right (RHEA:50033)
else
Function May hydrolyze fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis.
end case
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Similarity Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.
end case
GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0140042; Biological process: lipid droplet formation.

Cross-references [?]

Pfam PF10261; Scs3p; 1-2;

Computed features [?]

General Signal; -; 0-1;
Transmembrane; -; 0-7;

Features [?]

From: SCS3_YEAST (P53012)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     235     235             H   1
ACT_SITE     350     350             H   1

Additional information [?]

Size range 246-397 amino acids
Related rules None
Fusion None