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HAMAP rule MF_03231

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General rule information [?]

Accession MF_03231
Dates 11-NOV-2020 (Created)
20-MAY-2021 (Last updated, Version 3)
Name SCS3
Scope(s) Eukaryota
Template(s) P53012 (SCS3_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03231 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SCS3
case <FTGroup:1>
Protein name RecName: Full=Acyl-coenzyme A diphosphatase SCS3;
AltName: Full=FIT family protein SCS3;
Protein name RecName: Full=Acyl-coenzyme A diphosphatase SCS3 homolog;
AltName: Full=FIT family protein SCS3 homolog;
end case
Gene name Name=SCS3; Synonyms=FIT2B;

Comments [?]

case <FTGroup:1>
FUNCTIONFatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'- bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
CATALYTIC ACTIVITY Reaction=an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'- phosphopantetheine + 2 H(+); Xref=Rhea:RHEA:50044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58342, ChEBI:CHEBI:58343, ChEBI:CHEBI:132023; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50045;
CATALYTIC ACTIVITY Reaction=(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine; Xref=Rhea:RHEA:65564, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57387, ChEBI:CHEBI:58343, ChEBI:CHEBI:156553; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65565;
CATALYTIC ACTIVITY Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'- bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'- phosphopantetheine; Xref=Rhea:RHEA:65568, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57368, ChEBI:CHEBI:58343, ChEBI:CHEBI:156554; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65569;
CATALYTIC ACTIVITY Reaction=H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine; Xref=Rhea:RHEA:50032, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57379, ChEBI:CHEBI:58343, ChEBI:CHEBI:132018; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50033;
FUNCTIONMay hydrolyze fatty acyl-CoA to yield acyl-4'- phosphopantetheine and adenosine 3',5'-bisphosphate. May be required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis.
end case
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the FIT family. Fungal FIT2B/SCS3 subfamily.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
end case
GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0140042; Biological process:lipid droplet formation

Cross-references [?]

Pfam PF10261; Scs3p; 1-2;
General Signal; -; 0-1;
General Transmembrane; -; 0-7;

Features [?]

From: SCS3_YEAST (P53012)
Key From To Description Tag Condition FTGroup
ACT_SITE 235 235 H 1
ACT_SITE 350 350 H 1

Additional information [?]

Size range 246-397 amino acids
Related rules None
Fusion Nter: None Cter: None

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