HAMAP rule MF_04002
General rule information
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| Accession | MF_04002 |
| Dates | 27-NOV-2015 (Created) 20-NOV-2019 (Last updated, Version 6) |
| Name | PPV_L1 |
| Scope | Viruses; Papillomaviridae |
| Template | P03101 (VL1_HPV16) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2. |
| Subunit | Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation. Interacts with protein E2; this interaction enhances E2-dependent replication and transcription activation. |
| Subcellular location | Virion. Host nucleus. |
| Similarity | Belongs to the papillomaviridae L1 protein family. |
Keywords
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case <FTGroup:1>
end case
Host nucleus
Host-virus interaction
Late protein
Viral attachment to host cell
Viral penetration into host cytoplasm
Virion
Virus endocytosis by host
Virus entry into host cell
Host-virus interaction
Late protein
Viral attachment to host cell
Viral penetration into host cytoplasm
Virion
Virus endocytosis by host
Virus entry into host cell
Gene Ontology
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GO:0042025; Cellular component: host cell nucleus.
GO:0039620; Cellular component: T=7 icosahedral viral capsid.
GO:0005198; Molecular function: structural molecule activity.
GO:0019062; Biological process: virion attachment to host cell.
GO:0039620; Cellular component: T=7 icosahedral viral capsid.
GO:0005198; Molecular function: structural molecule activity.
GO:0019062; Biological process: virion attachment to host cell.
Cross-references
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Features
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| From: VL1_HPV16 (P03101) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 175 | 175 | Interchain (with #{Cys-428}) | C | 1 | |||||||
| DISULFID | 428 | 428 | Interchain (with #{Cys-175}) | C | 1 | |||||||
Additional information
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| Size range | 494-568 amino acids |
| Related rules | None |
| Fusion | None |