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HAMAP rule MF_04002

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General rule information [?]

Accession MF_04002
Dates 27-NOV-2015 (Created)
20-NOV-2019 (Last updated, Version 6)
Name PPV_L1
Viruses; Papillomaviridae
Template P03101 (VL1_HPV16)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Major capsid protein L1;
Gene name

Comments [?]

Function Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Subunit Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation. Interacts with protein E2; this interaction enhances E2-dependent replication and transcription activation.
Subcellular location Virion. Host nucleus.
Similarity Belongs to the papillomaviridae L1 protein family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0039620; Cellular component: T=7 icosahedral viral capsid.
GO:0005198; Molecular function: structural molecule activity.
GO:0019062; Biological process: virion attachment to host cell.

Cross-references [?]

Pfam PF00500; Late_protein_L1; 1;

Features [?]

From: VL1_HPV16 (P03101)
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     175     175       Interchain (with #{Cys-428})     C   1
DISULFID     428     428       Interchain (with #{Cys-175})     C   1

Additional information [?]

Size range 494-568 amino acids
Related rules None
Fusion None