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Annotation rule MF_04004
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General rule information [?]

Accession MF_04004
Dates 18-DEC-2015 (Created)
20-NOV-2019 (Last updated, Version 7)
Name PPV_E7
Viruses; Papillomaviridae
Template P03129 (VE7_HPV16)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Protein E7;
Gene name

Comments [?]

Function Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Subunit Homodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity. Interacts with host TMEM173/STING; this interaction impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Subcellular location Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Ptm Highly phosphorylated.
Similarity Belongs to the papillomaviridae E7 protein family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0046872; Molecular function: metal ion binding.
GO:0019904; Molecular function: protein domain specific binding.
GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0039645; Biological process: modulation by virus of host G1/S transition checkpoint.
GO:0039502; Biological process: suppression by virus of host type I interferon-mediated signaling pathway.
GO:0006351; Biological process: transcription, DNA-templated.

Cross-references [?]

Pfam PF00527; E7; 1;
PIRSF PIRSF003407; Papvi_E7; 1;

Features [?]

From: VE7_HPV16 (P03129)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     58     94             C-x*-C-x-x-C  
REGION     Nter     40       Disordered        
MOTIF     22     26       LXCXE motif; interaction with host RB1 and TMEM173/STING     L-x-C-x-E  
MOTIF     76     84       Nuclear export signal        

Additional information [?]

Size range 86-127 amino acids
Related rules None
Fusion None