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Annotation rule MF_04004
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General rule information [?]

Accession MF_04004
Dates 18-DEC-2015 (Created)
25-FEB-2021 (Last updated, Version 9)
Name PPV_E7
Viruses; Papillomaviridae
Template P03129 (VE7_HPV16)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Protein E7;
Gene name

Comments [?]

Function Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Subunit Homodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity. Interacts with host TMEM173/STING; this interaction impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Subcellular location Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Domain The E7 terminal domain is an intrinsically disordered domain, whose flexibility and conformational transitions confer target adaptability to the oncoprotein. It allows adaptation to a variety of protein targets and exposes the PEST degradation sequence that regulates its turnover in the cell.
Ptm Highly phosphorylated.
Similarity Belongs to the papillomaviridae E7 protein family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0046872; Molecular function: metal ion binding.
GO:0019904; Molecular function: protein domain specific binding.
GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0039645; Biological process: modulation by virus of host G1/S transition checkpoint.
GO:0039502; Biological process: suppression by virus of host type I interferon-mediated signaling pathway.
GO:0006351; Biological process: transcription, DNA-templated.

Cross-references [?]

Pfam PF00527; E7; 1;
PIRSF PIRSF003407; Papvi_E7; 1;

Features [?]

From: VE7_HPV16 (P03129)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     58     94                
REGION     Nter     40       E7 terminal domain     C-x*-C-x-x-C  
MOTIF     22     26       LXCXE motif; interaction with host RB1 and TMEM173/STING     L-x-C-x-E  
MOTIF     76     84       Nuclear export signal        

Additional information [?]

Size range 86-127 amino acids
Related rules None
Fusion None