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HAMAP rule MF_04004

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General rule information [?]

Accession MF_04004
Dates 18-DEC-2015 (Created)
28-JUL-2023 (Last updated, Version 11)
Name PPV_E7
Scope(s) Viruses
Template(s) P03129 (VE7_HPV16); [ Recover all ]
Triggered by HAMAP; MF_04004 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier VE7
Protein name RecName: Full=Protein E7;
Gene name Name=E7;

Comments [?]

FUNCTIONPlays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
SUBUNITHomodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity. Interacts with host TMEM173/STING; this interaction impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
SUBCELLULAR LOCATIONHost cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
DOMAINThe E7 terminal domain is an intrinsically disordered domain, whose flexibility and conformational transitions confer target adaptability to the oncoprotein. It allows adaptation to a variety of protein targets and exposes the PEST degradation sequence that regulates its turnover in the cell.
PTMHighly phosphorylated.
SIMILARITYBelongs to the papillomaviridae E7 protein family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0046872; Molecular function:metal ion binding
GO:0019904; Molecular function:protein domain specific binding
GO:0003700; Molecular function:DNA-binding transcription factor activity
GO:0039645; Biological process:perturbation by virus of host G1/S transition checkpoint
GO:0039502; Biological process:suppression by virus of host type I interferon-mediated signaling pathway
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

Pfam PF00527; E7; 1;
PIRSF PIRSF003407; Papvi_E7; 1;

Features [?]

From: VE7_HPV16 (P03129)
Key From To Description Tag Condition FTGroup
ZN_FING 58 94
REGION Nter 40 /note="E7 terminal domain" C-x*-C-x-x-C
MOTIF 22 26 /note="LXCXE motif; interaction with host RB1 and TMEM173/STING" L-x-C-x-E
MOTIF 76 84 /note="Nuclear export signal"

Additional information [?]

Size range 86-127 amino acids
Related rules None
Fusion Nter: None Cter: None

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