HAMAP rule MF_04010

General rule information [?]

Accession	MF_04010
Dates	22-FEB-2016 (Created) 20-NOV-2019 (Last updated, Version 3)

Name

HSV_HEPA

Scope

Viruses; Herpesviridae

Template

P10192 (HEPA_HHV11)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HEPA

Protein name

RecName:		Full=DNA helicase/primase complex-associated protein;
		Short=HEPA;
AltName:		Full=Primase-associated factor;

Comments [?]

Function	Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
Subunit	Associates with the primase and the helicase to form the helicase-primase complex. Interacts with the origin-binding protein. Interacts with the polymerase catalytic subunit.
Subcellular location	Host nucleus.
Similarity	Belongs to the herpesviridae HEPA family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0039686; Biological process: bidirectional double-stranded viral DNA replication.

Cross-references [?]

Pfam	PF03324; Herpes_HEPA; 1;
	PF05774; Herpes_heli_pri; 1;

Additional information [?]