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HAMAP rule MF_04010

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General rule information [?]

Accession MF_04010
Dates 22-FEB-2016 (Created)
20-NOV-2019 (Last updated, Version 3)
Viruses; Herpesviridae
Template P10192 (HEPA_HHV11)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA helicase/primase complex-associated protein;
AltName: Full=Primase-associated factor;

Comments [?]

Function Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
Subunit Associates with the primase and the helicase to form the helicase-primase complex. Interacts with the origin-binding protein. Interacts with the polymerase catalytic subunit.
Subcellular location Host nucleus.
Similarity Belongs to the herpesviridae HEPA family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0039686; Biological process: bidirectional double-stranded viral DNA replication.

Cross-references [?]

Pfam PF03324; Herpes_HEPA; 1;
PF05774; Herpes_heli_pri; 1;

Additional information [?]

Size range 610-873 amino acids
Related rules None
Fusion None