HAMAP rule MF_04010

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_04010
Accession	MF_04010
Dates	22-FEB-2016 (Created) 20-NOV-2019 (Last updated, Version 4)
Name	HSV_HEPA
Scope(s)	Viruses Herpesviridae
Template(s)	P10192; [ Recover all ]
Triggered by	HAMAP; MF_04010 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HEPA
Protein name	RecName: Full=DNA helicase/primase complex-associated protein; Short=HEPA; AltName: Full=Primase-associated factor;

Comments [?]

FUNCTION	Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
SUBUNIT	Associates with the primase and the helicase to form the helicase-primase complex. Interacts with the origin-binding protein. Interacts with the polymerase catalytic subunit.
SUBCELLULAR LOCATION	Host nucleus.
SIMILARITY	Belongs to the herpesviridae HEPA family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus

GO:0039686; Biological process:bidirectional double-stranded viral DNA replication

Cross-references [?]

Pfam	PF03324; Herpes_HEPA; 1;
Pfam	PF05774; Herpes_heli_pri; 1;

Features [?]

Additional information [?]