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HAMAP rule MF_04010

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General rule information [?]

Accession MF_04010
Dates 22-FEB-2016 (Created)
20-NOV-2019 (Last updated, Version 3)
Scope(s) Viruses
Template(s) P10192 (HEPA_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04010 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HEPA
RecName: Full=DNA helicase/primase complex-associated protein;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=HEPA;<br /> AltName: Full=Primase-associated factor;

Comments [?]

FUNCTIONComponent of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
SUBUNITAssociates with the primase and the helicase to form the helicase-primase complex. Interacts with the origin-binding protein. Interacts with the polymerase catalytic subunit.
SIMILARITYBelongs to the herpesviridae HEPA family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0039686; Biological process:bidirectional double-stranded viral DNA replication

Cross-references [?]

Pfam PF03324; Herpes_HEPA; 1;
Pfam PF05774; Herpes_heli_pri; 1;

Features [?]

Additional information [?]

Size range 610-873 amino acids
Related rules None
Fusion Nter: None Cter: None

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