HAMAP rule MF_04011
General rule information
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| Accession | MF_04011 |
| Dates | 3-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 4) |
| Name | HSV_PRIM |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P10236 (PRIM_HHV11); [ Recover all ] |
| Triggered by |
HAMAP; MF_04011 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PRIM |
| Protein name | RecName: Full=DNA primase; EC=2.7.7.-; |
Comments
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| FUNCTION | Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs. |
| SUBUNIT | Associates with the helicase and the primase-associated factor to form the helicase-primase factor. |
| SUBCELLULAR LOCATION | Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus. |
| SIMILARITY | Belongs to the herpesviridae DNA primase family. |
Keywords
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Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0003896; Molecular function:DNA primase activity |
| GO:0039686; Biological process:bidirectional double-stranded viral DNA replication |
Cross-references
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| Pfam | PF03121; Herpes_UL52; 1; |
Features
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| From: PRIM_HHV11 (P10236) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | 988 | 1028 | /note="CHC2-type" | C-x(4)-H-x*-C-x(4)-C | ||||||||
| SITE | 628 | 628 | /note="Essential for primase activity" | D | ||||||||
| SITE | 630 | 630 | /note="Essential for primase activity" | D | ||||||||
Additional information
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| Size range | 835-1293 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |