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HAMAP rule MF_04011

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General rule information [?]

Accession MF_04011
Dates 3-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P10236 (PRIM_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04011 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PRIM
Protein name RecName: Full=DNA primase;

Comments [?]

FUNCTIONEssential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
SUBUNITAssociates with the helicase and the primase-associated factor to form the helicase-primase factor.
SUBCELLULAR LOCATIONHost nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
SIMILARITYBelongs to the herpesviridae DNA primase family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0003896; Molecular function:DNA primase activity
GO:0039686; Biological process:bidirectional double-stranded viral DNA replication

Cross-references [?]

Pfam PF03121; Herpes_UL52; 1;

Features [?]

From: PRIM_HHV11 (P10236)
Key From To Description Tag Condition FTGroup
ZN_FING 988 1028 /note="CHC2-type" C-x(4)-H-x*-C-x(4)-C
SITE 628 628 /note="Essential for primase activity" D
SITE 630 630 /note="Essential for primase activity" D

Additional information [?]

Size range 835-1293 amino acids
Related rules None
Fusion Nter: None Cter: None

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