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HAMAP rule MF_04011

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General rule information [?]

Accession MF_04011
Dates 3-MAR-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Viruses; Herpesviridae
Template P10236 (PRIM_HHV11)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA primase;
EC 2.7.7.-;

Comments [?]

Function Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
Subunit Associates with the helicase and the primase-associated factor to form the helicase-primase factor.
Subcellular location Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Similarity Belongs to the herpesviridae DNA primase family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0003896; Molecular function: DNA primase activity.
GO:0039686; Biological process: bidirectional double-stranded viral DNA replication.

Cross-references [?]

Pfam PF03121; Herpes_UL52; 1;

Features [?]

From: PRIM_HHV11 (P10236)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     988     1028       CHC2-type     C-x(4)-H-x*-C-x(4)-C  
SITE     628     628       Essential for primase activity     D  
SITE     630     630       Essential for primase activity     D  

Additional information [?]

Size range 835-1293 amino acids
Related rules None
Fusion None