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HAMAP rule MF_04013

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General rule information [?]

Accession MF_04013
Dates 16-MAR-2016 (Created)
3-MAY-2022 (Last updated, Version 6)
Scope(s) Viruses
Template(s) P04295 (TRM3_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04013 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRM3
Protein name RecName: Full=Tripartite terminase subunit 3;
AltName: Full=Terminase large subunit;
Gene name Name=TRM3;

Comments [?]

FUNCTIONComponent of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
SUBUNITInteracts with the terminase subunits TRM1 and TRM2. Interacts with portal protein.
SUBCELLULAR LOCATIONHost nucleus. Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2.
SIMILARITYBelongs to the herpesviridae TRM3 protein family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0051276; Biological process:chromosome organization
GO:0019076; Biological process:viral release from host cell
GO:0004518; Molecular function:nuclease activity

Cross-references [?]

Pfam PF02499; DNA_pack_C; 1;
Pfam PF02500; DNA_pack_N; 1;

Features [?]

From: TRM3_HHV11 (P04295)
Key From To Description Tag Condition FTGroup
case <OC:Alphaherpesvirinae>
MOTIF 183 189 /note="Nuclear localization signal"
end case
MOTIF 258 265 /note="Walker A motif" [VI]-P-R-R-H-G-K-T
MOTIF 352 357 /note="Walker B motif" [LI]-L-[FYLI]-V-D-E
ACT_SITE 357 357 /note="For ATPase activity" E
ACT_SITE 509 509 /note="For nuclease activity" D
ACT_SITE 581 581 /note="For nuclease activity" E
ACT_SITE 707 707 /note="For nuclease activity" D

Additional information [?]

Size range 660-747 amino acids
Related rules None
Fusion Nter: None Cter: None

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