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Annotation rule MF_04013 |
General rule information
[?]
Accession |
MF_04013 |
Dates |
16-MAR-2016 (Created) 3-MAY-2022 (Last updated, Version 6) |
Scope |
Viruses; Herpesviridae |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Tripartite terminase subunit 3;
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EC 3.1.-.-;
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AltName:
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Full=Terminase large subunit;
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Function |
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes. |
Subunit |
Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein. |
Subcellular location |
Host nucleus. Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2. |
Similarity |
Belongs to the herpesviridae TRM3 protein family. |
GO:0042025; Cellular component: host cell nucleus.
GO:0051276; Biological process: chromosome organization.
GO:0019076; Biological process: viral release from host cell.
GO:0004518; Molecular function: nuclease activity.
case <OC:Alphaherpesvirinae>
From: TRM3_HHV11 (P04295) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOTIF
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183
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189
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Nuclear localization signal
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end case
MOTIF
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258
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265
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Walker A motif
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[VI]-P-R-R-H-G-K-T
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MOTIF
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352
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357
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Walker B motif
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[LI]-L-[FYLI]-V-D-E
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ACT_SITE
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357
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357
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For ATPase activity
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E
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ACT_SITE
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509
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509
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For nuclease activity
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D
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ACT_SITE
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581
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581
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For nuclease activity
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E
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ACT_SITE
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707
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707
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For nuclease activity
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D
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Additional information
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Size range |
660-747 amino acids |
Related rules |
None |
Fusion |
None |