HAMAP rule MF_04013
General rule information
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Accession | MF_04013 |
Dates | 16-MAR-2016 (Created) 3-MAY-2022 (Last updated, Version 6) |
Name | HSV_TRM3 |
Scope | Viruses; Herpesviridae |
Template | P04295 (TRM3_HHV11) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes. |
Subunit | Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein. |
Subcellular location | Host nucleus. Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2. |
Similarity | Belongs to the herpesviridae TRM3 protein family. |
Keywords
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Gene Ontology
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GO:0042025; Cellular component: host cell nucleus.
GO:0051276; Biological process: chromosome organization.
GO:0019076; Biological process: viral release from host cell.
GO:0004518; Molecular function: nuclease activity.
GO:0051276; Biological process: chromosome organization.
GO:0019076; Biological process: viral release from host cell.
GO:0004518; Molecular function: nuclease activity.
Cross-references
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Features
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case <OC:Alphaherpesvirinae>
From: TRM3_HHV11 (P04295) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 183 | 189 | Nuclear localization signal |
end case
Additional information
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Size range | 660-747 amino acids |
Related rules | None |
Fusion | None |