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HAMAP rule MF_04013

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General rule information [?]

Accession MF_04013
Dates 16-MAR-2016 (Created)
3-MAY-2022 (Last updated, Version 6)
Name HSV_TRM3
Scope
Viruses; Herpesviridae
Template P04295 (TRM3_HHV11)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRM3
Protein name
RecName: Full=Tripartite terminase subunit 3;
EC 3.1.-.-;
AltName: Full=Terminase large subunit;
Gene name
TRM3

Comments [?]

Function Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
Subunit Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein.
Subcellular location Host nucleus. Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2.
Similarity Belongs to the herpesviridae TRM3 protein family.

Keywords [?]

DNA-binding
Host nucleus
Hydrolase
Viral genome packaging
Viral release from host cell

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0051276; Biological process: chromosome organization.
GO:0019076; Biological process: viral release from host cell.
GO:0004518; Molecular function: nuclease activity.

Cross-references [?]

Pfam PF02499; DNA_pack_C; 1;
PF02500; DNA_pack_N; 1;

Features [?]

case <OC:Alphaherpesvirinae>
From: TRM3_HHV11 (P04295)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     183     189       Nuclear localization signal        
end case
MOTIF     258     265       Walker A motif     [VI]-P-R-R-H-G-K-T  
MOTIF     352     357       Walker B motif     [LI]-L-[FYLI]-V-D-E  
ACT_SITE     357     357       For ATPase activity     E  
ACT_SITE     509     509       For nuclease activity     D  
ACT_SITE     581     581       For nuclease activity     E  
ACT_SITE     707     707       For nuclease activity     D  

Additional information [?]

Size range 660-747 amino acids
Related rules None
Fusion None


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