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HAMAP rule MF_04023

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General rule information [?]

Accession MF_04023
Dates 22-APR-2016 (Created)
1-NOV-2022 (Last updated, Version 4)
Name HSV_NEC1
Scope(s) Viruses
Herpesviridae
Template(s) P10215 (NEC1_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04023 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NEC1
Protein name RecName: Full=Nuclear egress protein 1;
Gene name Name=NEC1;

Comments [?]

FUNCTIONPlays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
case <OC:Lymphocryptovirus>
SUBUNITForms a heterodimeric nuclear egress complex (NEC) with NEC2. 4 NEC further associate to form dimers. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.
else
SUBUNITForms a heterohexameric complex with NEC2. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.
end case
SUBCELLULAR LOCATIONHost nucleus inner membrane. Note=Remains attached to the nucleus inner membrane through interaction with NEC2.
PTMPhosphorylated at serine residues in the N-terminus. This phosphorylation regulates the localization within the inner nuclear membrane.
SIMILARITYBelongs to the herpesviridae NEC1 protein family.

Keywords [?]


Gene Ontology [?]

GO:0044201; Cellular component:host cell nuclear inner membrane
GO:0016020; Cellular component:membrane

Cross-references [?]

Pfam PF02718; Herpes_UL31; 1;

Features [?]

From: NEC1_HHV11 (P10215)
Key From To Description Tag Condition FTGroup
ZN_FING 106 225 /note="CCCH-type" C-x*-C-x(2)-C-x*-H

Additional information [?]

Size range 259-376 amino acids
Related rules None
Fusion Nter: None Cter: None



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