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HAMAP rule MF_04023

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General rule information [?]

Accession MF_04023
Dates 22-APR-2016 (Created)
1-NOV-2022 (Last updated, Version 4)
Name HSV_NEC1
Scope
Viruses; Herpesviridae
Template P10215 (NEC1_HHV11)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NEC1
Protein name
RecName: Full=Nuclear egress protein 1;
Gene name
NEC1

Comments [?]

Function Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
case <OC:Lymphocryptovirus>
Subunit Forms a heterodimeric nuclear egress complex (NEC) with NEC2. 4 NEC further associate to form dimers. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.
else
Subunit Forms a heterohexameric complex with NEC2. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.
end case
Subcellular location Host nucleus inner membrane. Note=Remains attached to the nucleus inner membrane through interaction with NEC2.
Ptm Phosphorylated at serine residues in the N-terminus. This phosphorylation regulates the localization within the inner nuclear membrane.
Similarity Belongs to the herpesviridae NEC1 protein family.

Keywords [?]

Host membrane
Host nucleus
Membrane
Metal-binding
Phosphoprotein
Zinc
Zinc-finger

Gene Ontology [?]

GO:0044201; Cellular component: host cell nuclear inner membrane.
GO:0016020; Cellular component: membrane.

Cross-references [?]

Pfam PF02718; Herpes_UL31; 1;

Features [?]

From: NEC1_HHV11 (P10215)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     106     225       CCCH-type     C-x*-C-x(2)-C-x*-H  

Additional information [?]

Size range 259-376 amino acids
Related rules None
Fusion None


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