HAMAP rule MF_04023
General rule information
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| Accession | MF_04023 |
| Dates | 22-APR-2016 (Created)
1-NOV-2022 (Last updated, Version 4) |
| Name | HSV_NEC1 |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P10215 (NEC1_HHV11); [ Recover all ] |
| Triggered by |
HAMAP; MF_04023 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NEC1 |
| Protein name | RecName: Full=Nuclear egress protein 1; |
| Gene name | Name=NEC1; |
Comments
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| FUNCTION | Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network. |
| case <OC:Lymphocryptovirus> | |
| SUBUNIT | Forms a heterodimeric nuclear egress complex (NEC) with NEC2. 4 NEC further associate to form dimers. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding. |
| else | |
| SUBUNIT | Forms a heterohexameric complex with NEC2. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding. |
| end case | |
| SUBCELLULAR LOCATION | Host nucleus inner membrane. Note=Remains attached to the nucleus inner membrane through interaction with NEC2. |
| PTM | Phosphorylated at serine residues in the N-terminus. This phosphorylation regulates the localization within the inner nuclear membrane. |
| SIMILARITY | Belongs to the herpesviridae NEC1 protein family. |
Keywords
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Gene Ontology
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| GO:0044201; Cellular component:host cell nuclear inner membrane |
| GO:0016020; Cellular component:membrane |
Cross-references
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| Pfam | PF02718; Herpes_UL31; 1; |
Features
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| From: NEC1_HHV11 (P10215) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | 106 | 225 | /note="CCCH-type" | C-x*-C-x(2)-C-x*-H | ||||||||
Additional information
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| Size range | 259-376 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |