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HAMAP rule MF_04024

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General rule information [?]

Accession MF_04024
Dates 22-APR-2016 (Created)
1-NOV-2022 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P10218 (NEC2_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04024 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NEC2
Protein name RecName: Full=Nuclear egress protein 2;
Gene name Name=NEC2;

Comments [?]

FUNCTIONPlays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
case <OC:Lymphocryptovirus>
SUBUNITForms a heterodimeric viral nuclear egress complex (NEC) with NEC1.
SUBUNITForms a heterohexameric complex with NEC1.
end case
SUBCELLULAR LOCATIONHost nucleus inner membrane; Single-pass membrane protein. Note=Localizes also at the transient membrane of perinuclear virions.
SIMILARITYBelongs to the herpesviridae NEC2 protein family.

Keywords [?]

Gene Ontology [?]

GO:0044201; Cellular component:host cell nuclear inner membrane
GO:0016020; Cellular component:membrane

Cross-references [?]

Pfam PF04541; Herpes_U34; 1;
General Transmembrane; -; 1;
ADD_TOPO_DOMAIN Perinuclear_space; -; 1;
ADD_TOPO_DOMAIN Nuclear; -; 1;

Features [?]

Additional information [?]

Size range 235-398 amino acids
Related rules None
Fusion Nter: None Cter: None

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