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Annotation rule MF_04024
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General rule information [?]

Accession MF_04024
Dates 22-APR-2016 (Created)
20-NOV-2019 (Last updated, Version 3)
Viruses; Herpesviridae
Template P10218 (NEC2_HHV11)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Nuclear egress protein 2;
Gene name

Comments [?]

Function Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
Subunit Forms a heterohexameric complex with NEC1.
Subcellular location Host nucleus inner membrane; Single-pass membrane protein. Note=Localizes also at the transient membrane of perinuclear virions.
Ptm Phosphorylated.
Similarity Belongs to the herpesviridae NEC2 protein family.

Keywords [?]

Gene Ontology [?]

GO:0044201; Cellular component: host cell nuclear inner membrane.
GO:0016020; Cellular component: membrane.

Cross-references [?]

Pfam PF04541; Herpes_U34; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;
ADD_TOPO_DOMAIN Perinuclear_space; -; 1; trigger=yes;
Nuclear; -; 1; trigger=yes;

Additional information [?]

Size range 235-398 amino acids
Related rules None
Fusion None