HAMAP rule MF_04029

General rule information [?]

Accession	MF_04029
Dates	9-MAY-2016 (Created) 19-NOV-2022 (Last updated, Version 7)

Name

HSV_KITH

Scope

Viruses; Herpesviridae

Template

P0DTH5 (KITH_HHV11)

Triggered by

HAMAP; MF_04029 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

KITH

Protein name

RecName:		Full=Thymidine kinase;
		EC 2.7.1.21;

Gene name

Comments [?]

Function	Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
Catalytic activity	RHEA:19129: ATP + thymidine = ADP + dTMP + H(+) EC 2.7.1.21
Subunit	Homodimer.
Similarity	Belongs to the herpesviridae thymidine kinase family.

Keywords [?]

ATP-binding
DNA synthesis
Early protein
Kinase
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004797; Molecular function: thymidine kinase activity.
GO:0071897; Biological process: DNA biosynthetic process.
GO:0006230; Biological process: TMP biosynthetic process.

Cross-references [?]

Pfam	PF00693; Herpes_TK; 1;
	PF08465; Herpes_TK_C; 1;
	PF02489; Herpes_glycop_H; 1;

Features [?]

From: KITH_HHV11 (P0DTH5)

Key From To Description Tag Condition FTGroup

BINDING 56 63 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-x-x-x-x-G-K-[TS]

ACT_SITE 83 83 Proton acceptor E

BINDING 101 101 /ligand="substrate Y

BINDING 125 125 /ligand="substrate Q

BINDING 216 216 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 R

BINDING 222 222 /ligand="substrate R

Additional information [?]

Size range	310-686 amino acids
Related rules	None
Fusion	None

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