HAMAP rule MF_04029
General rule information
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| Accession | MF_04029 |
| Dates | 9-MAY-2016 (Created)
19-NOV-2022 (Last updated, Version 7) |
| Name | HSV_KITH |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P0DTH5 (KITH_HHV11); [ Recover all ] |
| Triggered by |
HAMAP; MF_04029 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KITH |
| Protein name | RecName: Full=Thymidine kinase; EC=2.7.1.21; |
| Gene name | Name=TK; |
Comments
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| FUNCTION | Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors. |
| CATALYTIC ACTIVITY | Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21; |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the herpesviridae thymidine kinase family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0004797; Molecular function:thymidine kinase activity |
| GO:0071897; Biological process:DNA biosynthetic process |
| GO:0006230; Biological process:TMP biosynthetic process |
Cross-references
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Features
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| From: KITH_HHV11 (P0DTH5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 56 | 63 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-x-x-x-G-K-[TS] | ||||||||
| ACT_SITE | 83 | 83 | /note="Proton acceptor" | E | ||||||||
| BINDING | 101 | 101 | /ligand="substrate" | Y | ||||||||
| BINDING | 125 | 125 | /ligand="substrate" | Q | ||||||||
| BINDING | 216 | 216 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| BINDING | 222 | 222 | /ligand="substrate" | R | ||||||||
Additional information
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| Size range | 310-686 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |