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HAMAP rule MF_04029

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General rule information [?]

Accession MF_04029
Dates 9-MAY-2016 (Created)
19-NOV-2022 (Last updated, Version 7)
Viruses; Herpesviridae
Template P0DTH5 (KITH_HHV11)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Thymidine kinase;
Gene name

Comments [?]

Function Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
Catalytic activity RHEA:19129: ATP + thymidine = ADP + dTMP + H(+)
Subunit Homodimer.
Similarity Belongs to the herpesviridae thymidine kinase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004797; Molecular function: thymidine kinase activity.
GO:0071897; Biological process: DNA biosynthetic process.
GO:0006230; Biological process: TMP biosynthetic process.

Cross-references [?]

Pfam PF00693; Herpes_TK; 1;
PF08465; Herpes_TK_C; 1;
PF02489; Herpes_glycop_H; 1;

Features [?]

From: KITH_HHV11 (P0DTH5)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     56     63       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-x-x-x-x-G-K-[TS]  
ACT_SITE     83     83       Proton acceptor     E  
BINDING     101     101       /ligand="substrate     Y  
BINDING     125     125       /ligand="substrate     Q  
BINDING     216     216       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R  
BINDING     222     222       /ligand="substrate     R  

Additional information [?]

Size range 310-686 amino acids
Related rules None
Fusion None