HAMAP logo

HAMAP rule MF_04029

Send feedback

General rule information [?]

Accession MF_04029
Dates 9-MAY-2016 (Created)
19-NOV-2022 (Last updated, Version 7)
Scope(s) Viruses
Template(s) P0DTH5 (KITH_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04029 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KITH
Protein name RecName: Full=Thymidine kinase;
Gene name Name=TK;

Comments [?]

FUNCTIONCatalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
CATALYTIC ACTIVITY Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=;
SIMILARITYBelongs to the herpesviridae thymidine kinase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004797; Molecular function:thymidine kinase activity
GO:0071897; Biological process:DNA biosynthetic process
GO:0006230; Biological process:TMP biosynthetic process

Cross-references [?]

Pfam PF00693; Herpes_TK; 1;
Pfam PF08465; Herpes_TK_C; 1;
Pfam PF02489; Herpes_glycop_H; 1;

Features [?]

From: KITH_HHV11 (P0DTH5)
Key From To Description Tag Condition FTGroup
BINDING 56 63 /ligand="ATP"
ACT_SITE 83 83 /note="Proton acceptor" E
BINDING 101 101 /ligand="substrate" Y
BINDING 125 125 /ligand="substrate" Q
BINDING 216 216 /ligand="ATP"
BINDING 222 222 /ligand="substrate" R

Additional information [?]

Size range 310-686 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)