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HAMAP rule MF_04030

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General rule information [?]

Accession MF_04030
Dates 9-MAY-2016 (Created)
19-NOV-2022 (Last updated, Version 5)
Viruses; Herpesviridae
Template P10189 (HELI_HHV11)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA replication helicase;
EC 3.6.4.-;
Gene name

Comments [?]

Function Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
Subunit Associates with the primase and the primase-associated factor to form the helicase-primase complex.
Subcellular location Host nucleus.
Similarity Belongs to the herpesviridae helicase family.

Keywords [?]

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0005524; Molecular function: ATP binding.
GO:0004386; Molecular function: helicase activity.
GO:0039686; Biological process: bidirectional double-stranded viral DNA replication.

Cross-references [?]

Pfam PF02689; Herpes_Helicase; 1;

Features [?]

From: HELI_HHV11 (P10189)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     97     104       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-x-A-G-x-G-K-[ST]  

Additional information [?]

Size range 781-956 amino acids
Related rules None
Fusion None