HAMAP rule MF_04030
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_04030 |
| Accession | MF_04030 |
| Dates | 09-MAY-2016 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Name | HSV_HELI |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P10189; [ Recover all ] |
| Triggered by |
HAMAP; MF_04030 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HELI |
| Protein name | RecName: Full=DNA replication helicase; EC=3.6.4.-; |
| Gene name | Name=HELI; |
Comments
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| FUNCTION | Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex. |
| SUBUNIT | Associates with the primase and the primase-associated factor to form the helicase-primase complex. |
| SUBCELLULAR LOCATION | Host nucleus. |
| SIMILARITY | Belongs to the herpesviridae helicase family. |
Keywords
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Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0005524; Molecular function:ATP binding |
| GO:0004386; Molecular function:helicase activity |
| GO:0039686; Biological process:bidirectional double-stranded viral DNA replication |
Cross-references
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| Pfam | PF02689; Herpes_Helicase; 1; |
Features
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| From: HELI_HHV11 (P10189) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 97 | 104 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-A-G-x-G-K-[ST] | ||||||||
Additional information
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| Size range | 781-956 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |