HAMAP rule MF_04030

General rule information [?]

Accession	MF_04030
Dates	9-MAY-2016 (Created) 19-NOV-2022 (Last updated, Version 5)
Name	HSV_HELI
Scope(s)	Viruses Herpesviridae
Template(s)	P10189 (HELI_HHV11); [ Recover all ]
Triggered by	HAMAP; MF_04030 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HELI
RecName: Full=DNA replication helicase;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;
Gene name	Name=HELI;

Comments [?]

FUNCTION	Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
SUBUNIT	Associates with the primase and the primase-associated factor to form the helicase-primase complex.
SUBCELLULAR LOCATION	Host nucleus.
SIMILARITY	Belongs to the herpesviridae helicase family.

Keywords [?]

ATP-binding
DNA replication
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Host nucleus
Hydrolase
Nucleotide-binding

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus

GO:0005524; Molecular function:ATP binding

GO:0004386; Molecular function:helicase activity

GO:0039686; Biological process:bidirectional double-stranded viral DNA replication

Cross-references [?]

Pfam	PF02689; Herpes_Helicase; 1;

Features [?]

From: HELI_HHV11 (P10189)

Key

From

Description

Tag

Condition

FTGroup

BINDING

104

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

G-x-A-G-x-G-K-[ST]

Additional information [?]