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HAMAP rule MF_04030

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General rule information [?]

Accession MF_04030
Dates 9-MAY-2016 (Created)
19-NOV-2022 (Last updated, Version 5)
Scope(s) Viruses
Template(s) P10189 (HELI_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04030 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HELI
RecName: Full=DNA replication helicase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;
Gene name Name=HELI;

Comments [?]

FUNCTIONComponent of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
SUBUNITAssociates with the primase and the primase-associated factor to form the helicase-primase complex.
SIMILARITYBelongs to the herpesviridae helicase family.

Keywords [?]

DNA replication
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Host nucleus

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0005524; Molecular function:ATP binding
GO:0004386; Molecular function:helicase activity
GO:0039686; Biological process:bidirectional double-stranded viral DNA replication

Cross-references [?]

Pfam PF02689; Herpes_Helicase; 1;

Features [?]

From: HELI_HHV11 (P10189)
Key From To Description Tag Condition FTGroup
BINDING 97 104 /ligand="ATP"

Additional information [?]

Size range 781-956 amino acids
Related rules None
Fusion Nter: None Cter: None

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