HAMAP rule MF_04030
General rule information
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| Accession | MF_04030 |
| Dates | 9-MAY-2016 (Created) 19-NOV-2022 (Last updated, Version 5) |
| Name | HSV_HELI |
| Scope | Viruses; Herpesviridae |
| Template | P10189 (HELI_HHV11) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex. |
| Subunit | Associates with the primase and the primase-associated factor to form the helicase-primase complex. |
| Subcellular location | Host nucleus. |
| Similarity | Belongs to the herpesviridae helicase family. |
Keywords
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Gene Ontology
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GO:0042025; Cellular component: host cell nucleus.
GO:0005524; Molecular function: ATP binding.
GO:0004386; Molecular function: helicase activity.
GO:0039686; Biological process: bidirectional double-stranded viral DNA replication.
GO:0005524; Molecular function: ATP binding.
GO:0004386; Molecular function: helicase activity.
GO:0039686; Biological process: bidirectional double-stranded viral DNA replication.
Cross-references
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| Pfam | PF02689; Herpes_Helicase; 1; |
Features
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| From: HELI_HHV11 (P10189) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 97 | 104 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-x-A-G-x-G-K-[ST] | ||||||||
Additional information
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| Size range | 781-956 amino acids |
| Related rules | None |
| Fusion | None |