HAMAP rule MF_04031
General rule information
[?]
| Accession | MF_04031 |
| Dates | 9-MAY-2016 (Created)
14-MAY-2022 (Last updated, Version 6) |
| Name | HSV_DUT |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P10234 (DUT_HHV11); [ Recover all ] |
| Triggered by |
HAMAP; MF_04031 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | DUT |
| Protein name | RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase; Short=dUTPase; EC=3.6.1.23; AltName: Full=dUTP pyrophosphatase; |
| Gene name | Name=DUT; |
Comments
[?]
| FUNCTION | Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA. |
| CATALYTIC ACTIVITY | Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SIMILARITY | Belongs to the dUTPase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0004170; Molecular function:dUTP diphosphatase activity |
| GO:0046872; Molecular function:metal ion binding |
| GO:0046080; Biological process:dUTP metabolic process |
Cross-references
[?]
Features
[?]
| From: DUT_HHV11 (P10234) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 260 | 262 | /ligand="substrate" | R-S-[SG] | ||||||||
| BINDING | 366 | 367 | /ligand="substrate" | F-G | ||||||||
Additional information
[?]
| Size range | 268-436 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |