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HAMAP rule MF_04031

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General rule information [?]

Accession MF_04031
Dates 9-MAY-2016 (Created)
14-MAY-2022 (Last updated, Version 6)
Scope(s) Viruses
Template(s) P10234 (DUT_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04031 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DUT
Protein name RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase;
AltName: Full=dUTP pyrophosphatase;
Gene name Name=DUT;

Comments [?]

FUNCTIONInvolved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.
CATALYTIC ACTIVITY Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITYBelongs to the dUTPase family.

Keywords [?]

Gene Ontology [?]

GO:0004170; Molecular function:dUTP diphosphatase activity
GO:0046872; Molecular function:metal ion binding
GO:0046080; Biological process:dUTP metabolic process

Cross-references [?]

Pfam PF00692; dUTPase; 1;
Pfam PF04797; Herpes_ORF11; 1;

Features [?]

From: DUT_HHV11 (P10234)
Key From To Description Tag Condition FTGroup
BINDING 260 262 /ligand="substrate" R-S-[SG]
BINDING 366 367 /ligand="substrate" F-G

Additional information [?]

Size range 268-436 amino acids
Related rules None
Fusion Nter: None Cter: None

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