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Annotation rule MF_04031
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General rule information [?]

Accession MF_04031
Dates 9-MAY-2016 (Created)
14-MAY-2022 (Last updated, Version 6)
Name HSV_DUT
Scope
Viruses; Herpesviridae
Template P10234 (DUT_HHV11)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DUT
Protein name
RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase;
Short=dUTPase;
EC 3.6.1.23;
AltName: Full=dUTP pyrophosphatase;
Gene name
DUT

Comments [?]

Function Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.
Catalytic activity RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23
Cofactor Mg(2+)
Similarity Belongs to the dUTPase family.

Keywords [?]

Hydrolase
Magnesium
Metal-binding
Nucleotide metabolism

Gene Ontology [?]

GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0046080; Biological process: dUTP metabolic process.

Cross-references [?]

Pfam PF00692; dUTPase; 1;
PF04797; Herpes_ORF11; 1;

Features [?]

From: DUT_HHV11 (P10234)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     260     262       /ligand="substrate     R-S-[SG]  
BINDING     366     367       /ligand="substrate     F-G  

Additional information [?]

Size range 268-436 amino acids
Related rules None
Fusion None


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