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Annotation rule MF_04032
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General rule information [?]

Accession MF_04032
Dates 12-MAY-2016 (Created)
20-NOV-2019 (Last updated, Version 3)
Name HSV_GB
Scope
Viruses; Herpesviridae
Template P10211 (GB_HHV11)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GB
Protein name
RecName: Full=Envelope glycoprotein B;
Short=gB;
Flags: Precursor;
Gene name
gB

Comments [?]

Function Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
Subunit Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gH/gL heterodimer.
Subcellular location Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Similarity Belongs to the herpesviridae glycoprotein B family.

Keywords [?]


Gene Ontology [?]

GO:0044175; Cellular component: host cell endosome membrane.
GO:0044178; Cellular component: host cell Golgi membrane.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0046718; Biological process: viral entry into host cell.
GO:0019062; Biological process: virion attachment to host cell.

Cross-references [?]

Pfam PF00606; Glycoprotein_B; 1;
PF12154; HCMVantigenic_N; 1;
PROSITE PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=PRU00498;

Computed features [?]

General Signal; -; 1; trigger=yes;
Transmembrane; -; 1;

Features [?]

From: GB_HHV11 (P10211)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     774       Virion surface        
TRANSMEM     775     795       Helical        
TOPO_DOM     796     Cter       Intravirion        
REGION     173     179       Involved in fusion and/or binding to host membrane        
REGION     258     265       Involved in fusion and/or binding to host membrane        
REGION     719     772       Hydrophobic membrane proximal region        
MOTIF     849     852       Golgi targeting     Y-x-x-[LM]  
MOTIF     889     892       Internalization motif     Y-x-x-[VL]  
DISULFID     116     573             C-x*-C  
DISULFID     133     529             C-x*-C  
DISULFID     207     271             C-x*-C  
DISULFID     364     412             C-x*-C  
DISULFID     596     633             C-x*-C  

Additional information [?]

Size range 808-980 amino acids
Related rules None
Fusion None