HAMAP rule MF_04032
General rule information
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| Accession | MF_04032 |
| Dates | 12-MAY-2016 (Created)
1-MAR-2024 (Last updated, Version 5) |
| Name | HSV_GB |
| Scope(s) |
Viruses Herpesviridae |
| Template(s) | P10211 (GB_HHV11); [ Recover all ] |
| Triggered by |
HAMAP; MF_04032 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GB |
| Protein name | RecName: Full=Envelope glycoprotein B; Short=gB; Flags: Precursor; |
| Gene name | Name=gB; |
Comments
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| FUNCTION | Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. |
| SUBUNIT | Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gH/gL heterodimer. |
| SUBCELLULAR LOCATION | Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). |
| SIMILARITY | Belongs to the herpesviridae glycoprotein B family. |
Keywords
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Gene Ontology
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| GO:0044175; Cellular component:host cell endosome membrane |
| GO:0044178; Cellular component:host cell Golgi membrane |
| GO:0020002; Cellular component:host cell plasma membrane |
| GO:0016020; Cellular component:membrane |
| GO:0019031; Cellular component:viral envelope |
| GO:0055036; Cellular component:virion membrane |
| GO:0046718; Biological process:symbiont entry into host cell |
| GO:0019062; Biological process:virion attachment to host cell |
Cross-references
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| Pfam | PF00606; Glycoprotein_B; 1; |
| Pfam | PF12154; HCMVantigenic_N; 1; |
| General | Signal; -; 1; |
| General | Transmembrane; -; 1; |
| PROSITE | PS00001; ASN_GLYCOSYLATION; 0-unlimited; |
Features
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| From: GB_HHV11 (P10211) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 774 | /note="Virion surface" | |||||||||
| TRANSMEM | 775 | 795 | /note="Helical" | |||||||||
| TOPO_DOM | 796 | Cter | /note="Intravirion" | |||||||||
| REGION | 173 | 179 | /note="Involved in fusion and/or binding to host membrane" | |||||||||
| REGION | 258 | 265 | /note="Involved in fusion and/or binding to host membrane" | |||||||||
| REGION | 719 | 772 | /note="Hydrophobic membrane proximal region" | |||||||||
| MOTIF | 849 | 852 | /note="Golgi targeting" | Y-x-x-[LM] | ||||||||
| MOTIF | 889 | 892 | /note="Internalization motif" | Y-x-x-[VL] | ||||||||
| DISULFID | 116 | 573 | C-x*-C | |||||||||
| DISULFID | 133 | 529 | C-x*-C | |||||||||
| DISULFID | 207 | 271 | C-x*-C | |||||||||
| DISULFID | 364 | 412 | C-x*-C | |||||||||
| DISULFID | 596 | 633 | C-x*-C | |||||||||
Additional information
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| Size range | 808-980 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |