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HAMAP rule MF_04032

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General rule information [?]

Accession MF_04032
Dates 12-MAY-2016 (Created)
1-MAR-2024 (Last updated, Version 5)
Scope(s) Viruses
Template(s) P10211 (GB_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04032 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GB
Protein name RecName: Full=Envelope glycoprotein B;
                 Flags: Precursor;
Gene name Name=gB;

Comments [?]

FUNCTIONEnvelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
SUBUNITHomotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gH/gL heterodimer.
SUBCELLULAR LOCATIONVirion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
SIMILARITYBelongs to the herpesviridae glycoprotein B family.

Keywords [?]

Gene Ontology [?]

GO:0044175; Cellular component:host cell endosome membrane
GO:0044178; Cellular component:host cell Golgi membrane
GO:0020002; Cellular component:host cell plasma membrane
GO:0016020; Cellular component:membrane
GO:0019031; Cellular component:viral envelope
GO:0055036; Cellular component:virion membrane
GO:0046718; Biological process:symbiont entry into host cell
GO:0019062; Biological process:virion attachment to host cell

Cross-references [?]

Pfam PF00606; Glycoprotein_B; 1;
Pfam PF12154; HCMVantigenic_N; 1;
General Signal; -; 1;
General Transmembrane; -; 1;

Features [?]

From: GB_HHV11 (P10211)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 774 /note="Virion surface"
TRANSMEM 775 795 /note="Helical"
TOPO_DOM 796 Cter /note="Intravirion"
REGION 173 179 /note="Involved in fusion and/or binding to host membrane"
REGION 258 265 /note="Involved in fusion and/or binding to host membrane"
REGION 719 772 /note="Hydrophobic membrane proximal region"
MOTIF 849 852 /note="Golgi targeting" Y-x-x-[LM]
MOTIF 889 892 /note="Internalization motif" Y-x-x-[VL]
DISULFID 116 573 C-x*-C
DISULFID 133 529 C-x*-C
DISULFID 207 271 C-x*-C
DISULFID 364 412 C-x*-C
DISULFID 596 633 C-x*-C

Additional information [?]

Size range 808-980 amino acids
Related rules None
Fusion Nter: None Cter: None

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