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Annotation rule MF_04033
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General rule information [?]

Accession MF_04033
Dates 13-MAY-2016 (Created)
20-NOV-2019 (Last updated, Version 3)
Viruses; Herpesviridae
Template P06477 (GH_HHV11)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Envelope glycoprotein H;
Flags: Precursor;
Gene name

Comments [?]

Function The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
Subunit Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
Subcellular location Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Ptm N-glycosylated, O-glycosylated, and sialylated.
Similarity Belongs to the herpesviridae glycoprotein H family.

Keywords [?]

Gene Ontology [?]

GO:0044175; Cellular component: host cell endosome membrane.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0016021; Cellular component: integral component of membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.

Cross-references [?]

Pfam PF02489; Herpes_glycop_H; 1;
PROSITE PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=PRU00498;

Computed features [?]

General Signal; -; 1; trigger=yes;
Transmembrane; -; 1;

Features [?]

From: GH_HHV11 (P06477)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     803       Virion surface        
TRANSMEM     804     824       Helical        
TOPO_DOM     825     Cter       Intravirion        
REGION     259     323       Interaction with gL        

Additional information [?]

Size range 686-855 amino acids
Related rules None
Fusion None