HAMAP logo

HAMAP rule MF_04033

Send feedback

General rule information [?]

Accession MF_04033
Dates 13-MAY-2016 (Created)
29-SEP-2022 (Last updated, Version 4)
Scope(s) Viruses
Template(s) P06477 (GH_HHV11); [ Recover all ]
Triggered by HAMAP; MF_04033 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GH
Protein name RecName: Full=Envelope glycoprotein H;
                 Flags: Precursor;
Gene name Name=gH;

Comments [?]

FUNCTIONThe heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
SUBUNITInteracts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
SUBCELLULAR LOCATIONVirion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
PTMN-glycosylated, O-glycosylated, and sialylated.
SIMILARITYBelongs to the herpesviridae glycoprotein H family.

Keywords [?]

Gene Ontology [?]

GO:0044175; Cellular component:host cell endosome membrane
GO:0020002; Cellular component:host cell plasma membrane
GO:0016020; Cellular component:membrane
GO:0019031; Cellular component:viral envelope
GO:0055036; Cellular component:virion membrane
GO:0019064; Biological process:fusion of virus membrane with host plasma membrane

Cross-references [?]

Pfam PF02489; Herpes_glycop_H; 1;
General Signal; -; 1;
General Transmembrane; -; 1;

Features [?]

From: GH_HHV11 (P06477)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 803 /note="Virion surface"
TRANSMEM 804 824 /note="Helical"
TOPO_DOM 825 Cter /note="Intravirion"
REGION 259 323 /note="Interaction with gL"

Additional information [?]

Size range 686-855 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)