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Annotation rule MF_04034 |
Accession | MF_04034 |
Dates | 5-SEP-2016 (Created) 20-NOV-2019 (Last updated, Version 5) |
Name | HSV_GL_alphagamma |
Scope | Viruses; Herpesviridae |
Templates | P10185 (GL_HHV11); P03212 (GL_EBVB9); F5HDB7 (GL_HHV8P): [Recover all] |
Triggered by |
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Protein name |
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Function | The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. |
Subunit | Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion. |
Subcellular location | Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. |
Similarity | Belongs to the herpesviridae glycoprotein L family. |
General | Signal; -; 0-1; trigger=yes; |
From: GL_HHV11 (P10185) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 20 | 161 | Interaction with gH |
Size range | 137-224 amino acids |
Related rules | None |
Fusion | None |