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| Annotation rule MF_04034 |
General rule information
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| Accession | MF_04034 |
| Dates | 5-SEP-2016 (Created) 20-NOV-2019 (Last updated, Version 5) |
| Name | HSV_GL_alphagamma |
| Scope | Viruses; Herpesviridae |
| Templates | P10185 (GL_HHV11); P03212 (GL_EBVB9); F5HDB7 (GL_HHV8P): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. |
| Subunit | Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion. |
| Subcellular location | Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. |
| Similarity | Belongs to the herpesviridae glycoprotein L family. |
Keywords
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Fusion of virus membrane with host cell membrane
Fusion of virus membrane with host membrane
Glycoprotein
Host cell membrane
Host Golgi apparatus
Host membrane
Membrane
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virus entry into host cell
Fusion of virus membrane with host membrane
Glycoprotein
Host cell membrane
Host Golgi apparatus
Host membrane
Membrane
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virus entry into host cell
Gene Ontology
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GO:0020002; Cellular component: host cell plasma membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
Cross-references
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Computed features
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| General | Signal; -; 0-1; trigger=yes; |
Features
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| From: GL_HHV11 (P10185) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 20 | 161 | Interaction with gH | |||||||||
Additional information
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| Size range | 137-224 amino acids |
| Related rules | None |
| Fusion | None |