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HAMAP rule MF_04034

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General rule information [?]

Accession MF_04034
Dates 5-SEP-2016 (Created)
20-NOV-2019 (Last updated, Version 5)
Name HSV_GL_alphagamma
Viruses; Herpesviridae
Templates P10185 (GL_HHV11); P03212 (GL_EBVB9); F5HDB7 (GL_HHV8P): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Envelope glycoprotein L;
Gene name

Comments [?]

Function The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
Subunit Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
Subcellular location Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
Similarity Belongs to the herpesviridae glycoprotein L family.

Keywords [?]

Gene Ontology [?]

GO:0020002; Cellular component: host cell plasma membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.

Cross-references [?]

Pfam PF12524; GlyL_C; 1;
PF05259; Herpes_UL1; 1;
PF11108; Phage_glycop_gL; 1;

Computed features [?]

General Signal; -; 0-1; trigger=yes;

Features [?]

From: GL_HHV11 (P10185)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     20     161       Interaction with gH        

Additional information [?]

Size range 137-224 amino acids
Related rules None
Fusion None