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HAMAP rule MF_04034

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General rule information [?]

Accession MF_04034
Dates 5-SEP-2016 (Created)
11-JUL-2023 (Last updated, Version 6)
Name HSV_GL_alphagamma
Scope(s) Viruses
Template(s) P10185 (GL_HHV11); P03212 (GL_EBVB9); F5HDB7 (GL_HHV8P); [ Recover all ]
Triggered by HAMAP; MF_04034 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GL
Protein name RecName: Full=Envelope glycoprotein L;
Gene name Name=gL;

Comments [?]

FUNCTIONThe heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.
SUBUNITInteracts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
SUBCELLULAR LOCATIONVirion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.

Keywords [?]

Gene Ontology [?]

GO:0020002; Cellular component:host cell plasma membrane
GO:0019031; Cellular component:viral envelope
GO:0055036; Cellular component:virion membrane
GO:0019064; Biological process:fusion of virus membrane with host plasma membrane

Cross-references [?]

Pfam PF12524; GlyL_C; 1;
Pfam PF05259; Herpes_UL1; 1;
Pfam PF11108; Phage_glycop_gL; 1;
General Signal; -; 0-1;
PROSITE PS52024; GL_AHV; 0-1;
PROSITE PS52026; GL_GHV; 0-1;

Features [?]

From: GL_HHV11 (P10185)
Key From To Description Tag Condition FTGroup
REGION 20 161 /note="Interaction with gH"

Additional information [?]

Size range 137-224 amino acids
Related rules None
Fusion Nter: None Cter: None

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